Giovanni Tortorella
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Giovanni Tortorella has a total of 20 co-authors. Here are the top co-authors by number of shared publications:
- Aldo Marrone
Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
1 shared publication - Antonio Russo
Link Campus University, Via del Casale di San Pio V, Rome, Italy
1 shared publication - Carmen Ricozzi
Infectious Diseases Unit, AOU Luigi Vanvitelli, 80131 Naples, Italy
1 shared publication - Davide Mastrocinque
Liver Unit, Ospedale Evangelico Betania, 80147 Naples, Italy
1 shared publication - Domenico Cozzolino
Division of Internal Medicine, Department of Precision Medicine, “Luigi Vanvitelli” University of Campania, 80131 Naples, Italy
1 shared publication - Ernesto Claar
Liver Unit, Ospedale Evangelico Betania, 80147 Naples, Italy
1 shared publication
Latest Publications
- Top Cited PapersOpen Access
Gender Differences in the Pathogenesis and Risk Factors of Hepatocellular Carcinoma
Several chronic liver diseases are characterized by a clear gender disparity. Among them, hepatocellular carcinoma (HCC) shows significantly higher incidence rates in men than in women. The different epidemiological distribution of risk factors for liver disease and HCC only partially accounts for these gender differences. In fact, the liver is an organ with recognized sexual dysmorphism and is extremely sensitive to the action of androgens and estrogens. Sex hormones act by modulating the risk of developing HCC and influencing its aggressiveness, response to treatments, and prognosis. Furthermore, androgens and estrogens are able to modulate the action of other factors and cofactors of liver damage (e.g., chronic HBV infection, obesity), significantly influencing their carcinogenic power. The purpose of this review is to examine the factors related to the different gender distribution in the incidence of HCC as well as the pathophysiological mechanisms involved, with particular reference to the central role played by sex hormones.
Top Cited PapersOpen AccessGender Differences in the Pathogenesis and Risk Factors of Hepatocellular Carcinoma
Several chronic liver diseases are characterized by a clear gender disparity. Among them, hepatocellular carcinoma (HCC) shows significantly higher incidence rates in men than in women. The different epidemiological distribution of risk factors for liver disease and HCC only partially accounts for these gender differences. In fact, the liver is an organ with recognized sexual dysmorphism and is extremely sensitive to the action of androgens and estrogens. Sex hormones act by modulating the risk of developing HCC and influencing its aggressiveness, response to treatments, and prognosis. Furthermore, androgens and estrogens are able to modulate the action of other factors and cofactors of liver damage (e.g., chronic HBV infection, obesity), significantly influencing their carcinogenic power. The purpose of this review is to examine the factors related to the different gender distribution in the incidence of HCC as well as the pathophysiological mechanisms involved, with particular reference to the central role played by sex hormones.