Zhigao Sun
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Zhigao Sun has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Jieqiong Lin
Department of Pathology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, China
1 shared publication - Pei Zhang
School of Life Science, Beijing Institute of Technology, Beijing, China
1 shared publication - Shihui Fu
Department of Cardiology, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, China
1 shared publication - Yali Zhao
Central Laboratory, Hainan Hospital of Chinese People’s Liberation Army General Hospital, Sanya, China
1 shared publication - Yao Yao
China Center for Health Development Studies, Peking University, Beijing, China
1 shared publication - Yujie Zhang
Department of Geriatrics, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China. (B.-B.H., X.Y., Y.-J.C., Y.-B.L., M.-Z.Y., Y.-F.Q., F.-Y.Z., L.-D.X., L.L., Y.-J.Z.)
1 shared publication
Latest Publications
- Open Access
- 23 May 2022
- Published by Springer Nature in Immunity & Ageing
- Vol. 19 (1) , 1-6
Association between immunoglobulin A and depression in Chinese older adults: findings from a cross-sectional study
Background: Depression is considered to be an immune-related disease; however, previous studies have focused on inflammatory factors, and there is no conclusive conclusion on the relationships between immunoglobulins and depression. Therefore, the objective of this cross-sectional study was to evaluate the associations between immunoglobulins and depressive symptoms in Chinese older adults. Results: The China Hainan Centenarian Cohort Study (CHCCS) provides a significant population-based sample of older adults in Hainan, China. A total of 1547 older adults were included in this study. A baseline survey was conducted using a structured questionnaire. Blood samples were obtained following standard procedures. The Geriatric Depression Scale (GDS-15) was used to evaluate depressive symptoms of the participants. This sample of older adults had a median age of 94.75 (range: 80–116) years, and the proportion of women was 72.07%. The prevalence of older adults with depressive symptoms was 20.36% (315 older adults). After adjusting for all covariates, we found that immunoglobulin A levels were positively associated with depression. The adjusted reliability of the association between immunoglobulin A and depression was 0.106 (beta) and 1.083 (odds ratio) (P < 0.05 for both). Conclusions: The present study provides epidemiological evidence that depression has significant associations with immunoglobulin A levels in older adults. Further research should be conducted on the effects of regulating immunoglobulin A to improve depressive symptoms.
- 23 May 2022
- Published by Springer Nature in Immunity & Ageing
- Vol. 19 (1) , 1-6
Open AccessAssociation between immunoglobulin A and depression in Chinese older adults: findings from a cross-sectional study
Background: Depression is considered to be an immune-related disease; however, previous studies have focused on inflammatory factors, and there is no conclusive conclusion on the relationships between immunoglobulins and depression. Therefore, the objective of this cross-sectional study was to evaluate the associations between immunoglobulins and depressive symptoms in Chinese older adults. Results: The China Hainan Centenarian Cohort Study (CHCCS) provides a significant population-based sample of older adults in Hainan, China. A total of 1547 older adults were included in this study. A baseline survey was conducted using a structured questionnaire. Blood samples were obtained following standard procedures. The Geriatric Depression Scale (GDS-15) was used to evaluate depressive symptoms of the participants. This sample of older adults had a median age of 94.75 (range: 80–116) years, and the proportion of women was 72.07%. The prevalence of older adults with depressive symptoms was 20.36% (315 older adults). After adjusting for all covariates, we found that immunoglobulin A levels were positively associated with depression. The adjusted reliability of the association between immunoglobulin A and depression was 0.106 (beta) and 1.083 (odds ratio) (P < 0.05 for both). Conclusions: The present study provides epidemiological evidence that depression has significant associations with immunoglobulin A levels in older adults. Further research should be conducted on the effects of regulating immunoglobulin A to improve depressive symptoms.