Ruiyan Liu
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Ruiyan Liu has a total of 15 co-authors. Here are the top co-authors by number of shared publications:
- Lihua Chen
Department of Immunology, School of Basic Medicine, Air Force Medical University
2 shared publications - Bin Wu
Department of Pulmonary and Critical Care Medicine Xijing Hospital, Fourth Military Medical University Xi'an China
1 shared publication - Feng Zhao
Department of Pulmonary and Critical Care Medicine, Xijing Hospital, Fourth Military Medical University, Xi’an, China
1 shared publication Kang Tang
Fourth Military Medical University
1 shared publication- Kang Tang
Department of Immunology, The Fourth Military Medical University, Xi’an 710032, China
1 shared publication Wenwei Guo
The Second Military Medical University
1 shared publication
Latest Publications
- 1 July 2023
- Published by Wiley in The FASEB Journal
- Vol. 37 (8) , e23047
CD226 deficiency attenuates cardiac early pathological remodeling and dysfunction via decreasing inflammatory macrophage proportion and macrophage glycolysis in STZ ‐induced diabetic mice
Diabetic cardiomyopathy (DCM) is one of the main complications in type I diabetic patients. Activated macrophage is critical for directing the process of inflammation during the development of DCM. The present study focused on the roles of CD226 on macrophage function during the DCM progression. It has been found that the number of cardiac macrophages in the hearts of streptozocin (STZ)‐induced diabetes mice was significantly increased compared with that in non‐diabetes mice, and the expression level of CD226 on cardiac macrophages in STZ‐induced diabetes mice was higher than that in non‐diabetes mice. CD226 deficiency attenuated the diabetes‐induced cardiac dysfunction and decreased the proportion of CD86 + F4/80 + macrophages in the diabetic hearts. Notably, adoptive transfer of Cd226 −/− ‐ bone marrow derived macrophages (BMDMs) alleviated diabetes‐induced cardiac dysfunction, which may be due to the attenuated migration capacity of Cd226 −/− ‐BMDM under high glucose stimulation. Furthermore, CD226 deficiency decreased the macrophage glycolysis accompanying by the downregulated hexokinase 2 (HK2) and lactate dehydrogenase A (LDH‐A) expression. Taken together, these findings revealed the pathogenic roles of CD226 played in the process of DCM and provided a basis for the treatment of DCM.
- 1 July 2023
- Published by Wiley in The FASEB Journal
- Vol. 37 (8) , e23047
CD226 deficiency attenuates cardiac early pathological remodeling and dysfunction via decreasing inflammatory macrophage proportion and macrophage glycolysis in STZ ‐induced diabetic mice
Diabetic cardiomyopathy (DCM) is one of the main complications in type I diabetic patients. Activated macrophage is critical for directing the process of inflammation during the development of DCM. The present study focused on the roles of CD226 on macrophage function during the DCM progression. It has been found that the number of cardiac macrophages in the hearts of streptozocin (STZ)‐induced diabetes mice was significantly increased compared with that in non‐diabetes mice, and the expression level of CD226 on cardiac macrophages in STZ‐induced diabetes mice was higher than that in non‐diabetes mice. CD226 deficiency attenuated the diabetes‐induced cardiac dysfunction and decreased the proportion of CD86 + F4/80 + macrophages in the diabetic hearts. Notably, adoptive transfer of Cd226 −/− ‐ bone marrow derived macrophages (BMDMs) alleviated diabetes‐induced cardiac dysfunction, which may be due to the attenuated migration capacity of Cd226 −/− ‐BMDM under high glucose stimulation. Furthermore, CD226 deficiency decreased the macrophage glycolysis accompanying by the downregulated hexokinase 2 (HK2) and lactate dehydrogenase A (LDH‐A) expression. Taken together, these findings revealed the pathogenic roles of CD226 played in the process of DCM and provided a basis for the treatment of DCM.
- Open Access
- 1 January 2022
- Published by Elsevier in SSRN Electronic Journal
Increased NKp44 Expression on CD56dimCD16+ NK Cells in Tumor Microenvironment by Tetrahydropalmatine Derived from Corydalis Yanhusuo W. T. Wang
Natural killer (NK) cells, especially CD56dim CD16+ NK cells play a key role in anticancer immune response. An increasing body of evidence suggests that the phenotype of NK cells undergoes crucial alterations in tumor microenvironment, embodied in cytotoxic NK cells decreased while secretory NK cells increased. Therefore, these alterations are associated with the progress of the tumor. In our study, we demonstrated that CD56dim CD16+ NK cells were significantly decreased in microenvironment of JEG-3 cells. dl-tetrahydropalmatine (dl-THP) is one of the active alkaloids of Chinese herb Yanhusuo. Here, we found that dl-THP significantly enhance NKp44 receptor both on peripheral blood CD56dim CD16+ NK cells and CD56 dim CD16+ NK cells which were reduced in tumor microenvironment. Thus, our data revealed that the potential auxiliary herb therapy for Choriocarcinoma.
- 1 January 2022
- Published by Elsevier in SSRN Electronic Journal
Open AccessIncreased NKp44 Expression on CD56dimCD16+ NK Cells in Tumor Microenvironment by Tetrahydropalmatine Derived from Corydalis Yanhusuo W. T. Wang
Natural killer (NK) cells, especially CD56dim CD16+ NK cells play a key role in anticancer immune response. An increasing body of evidence suggests that the phenotype of NK cells undergoes crucial alterations in tumor microenvironment, embodied in cytotoxic NK cells decreased while secretory NK cells increased. Therefore, these alterations are associated with the progress of the tumor. In our study, we demonstrated that CD56dim CD16+ NK cells were significantly decreased in microenvironment of JEG-3 cells. dl-tetrahydropalmatine (dl-THP) is one of the active alkaloids of Chinese herb Yanhusuo. Here, we found that dl-THP significantly enhance NKp44 receptor both on peripheral blood CD56dim CD16+ NK cells and CD56 dim CD16+ NK cells which were reduced in tumor microenvironment. Thus, our data revealed that the potential auxiliary herb therapy for Choriocarcinoma.