Shuwen Xu

Objective. Multimodal medical image fusion (MMIF) technologies merges diverse medical images with rich information, boosting diagnostic efficiency and accuracy. Due to global optimization and single-valued nature, convolutional sparse representation (CSR) outshines the standard sparse representation (SR) in significance. By addressing the challenges of sensitivity to highly redundant dictionaries and robustness to misregistration, an adaptive convolutional sparsity scheme with measurement of the sub-band correlation in the non-subsampled contourlet transform (NSCT) domain is proposed for MMIF. Approach. The fusion scheme incorporates four main components: image decomposition into two scales, fusion of detail layers, fusion of base layers, and reconstruction of the two scales. We solved a Tikhonov regularization optimization problem with source images to obtain the base and detail layers. Then, after CSR processing, detail layers were sparsely decomposed using pre-trained dictionary filters for initial coefficient maps. NSCT domain’s sub-band correlation was used to refine fusion coefficient maps, and sparse reconstruction produced the fused detail layer. Meanwhile, base layers were fused using averaging. The final fused image was obtained via two-scale reconstruction. Main results. Experimental validation of clinical image sets revealed that the proposed fusion scheme can not only effectively eliminate the interference of partial misregistration, but also outperform the representative state-of-the-art fusion schemes in the preservation of structural and textural details according to subjective visual evaluations and objective quality evaluations. Significance. The proposed fusion scheme is competitive due to its low-redundancy dictionary, robustness to misregistration, and better fusion performance. This is achieved by training the dictionary with minimal samples through CSR to adaptively preserve overcompleteness for detail layers, and constructing fusion activity level with sub-band correlation in the NSCT domain to maintain CSR attributes. Additionally, ordering the NSCT for reverse sparse representation further enhances sub-band correlation to promote the preservation of structural and textural details.

Multimodal medical image fusion is a fundamental, but challenging, problem in the fields of brain science research and brain disease diagnosis, as it is challenging for sparse representation (SR)-based fusion to characterize activity levels with a single measurement and not lose effective information. In this study, the Kronecker-criterion-based SR framework was applied for medical image fusion with a patch-based activity level, integrating salient features of multiple domains. Inspired by the formation process of vision systems, the spatial saliency was characterized by textural contrast (TC), composed of luminance and orientation contrasts, to promote the participation of more highlighted textural information in the fusion process. As a substitute for the conventional l₁-norm-based sparse saliency, the sum of sparse salient features (SSSF) was used as a metric for promoting the participation of more significant coefficients in the composition of the activity level measurement. The designed activity level measurement was verified to be more conducive to maintaining the integrity and sharpness of detailed information. Various experiments on multiple groups of clinical medical images verified the effectiveness of the proposed fusion method in terms of both visual quality and objective assessment. Furthermore, this study will be helpful for the further detection and segmentation of medical images.

Multimodal medical image fusion is a fundamental but challenging problem in the fields of brain science research and brain disease diagnosis, and it is challenging for sparse representation (SR)-based fusion to characterize activity level with single measurement and no loss of effective information. In this paper, the Kronecker-criterion-based SR framework is applied for medical image fusion with a patch-based activity level integrating salient features of multiple domains. Inspired by the formation process of vision system, the spatial saliency is characterized by textural contrast (TC), which is composed of luminance and orientation contrasts to promote more highlighted texture information to participate in the fusion process. As substitution of the conventional l1-norm-based sparse saliency, a metric of sum of sparse salient features (SSSF) is used for promoting more significant coefficients to participate in the composition of activity level measure. The designed activity level measure is verified to be more conducive to maintain the integrity and sharpness of detailed information. Various experiments on multiple groups of clinical medical images verify the effectiveness of the proposed fusion method on both visual quality and objective assessment. Furthermore, the research work of this paper is helpful for further detection and segmentation of medical images.