Gemino Fiorelli
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Gemino Fiorelli has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
Bruno Mario Cesana
1 shared publication- Lorena Duca
SC Medicina ad Indirizzo Metabolico, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy
1 shared publication - Maria Domenica Cappellini
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, SC Medicina ad Indirizzo Metabolico Milan Italy
1 shared publication Maurizio Sampietro
Dipartimento di Medicina Interna Università di Milano, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
1 shared publication- Michela Mattioli
Center for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia (IIT), Milan, Italy
1 shared publication Silvia Fargion
Dipartimento di Medicina Interna Università di Milano, Ospedale Maggiore Policlinico IRCCS, Milano, Italy
1 shared publication
Latest Publications
- Open Access
- 1 March 1999
- Published by Wolters Kluwer Health in Hepatology
- Vol. 29 (3) , 658-663
Carbohydrate–Deficient Transferrin, A Sensitive Marker of Chronic Alcohol Abuse, Is Highly Influenced by Body Iron
Carbohydrate–deficient transferrin(CDT) a microheterogeneous form of serum transferrin (Tf) has been proposed as the most reliable marker of chronic alcohol consumption, although unexplained false–positive and –negative results have been reported.We investigated whether body iron influenced CDT serum levels by studying alcohol abusers with or without iron overload and nonabusers with iron deficiency or iron overload caused by genetic hemochromatosis (GH).In alcohol abusers, CDT was significantly lower in the presence of iron overload than in the absence (24.6 ±16.5 U/L vs.33.3 ±11.7 U/L; P<.01) with false–negative results almost exclusively in patients with iron overload. Similarly, in nonabusers with GH, CDT was lower than in normal controls (9.6±2.2 U/L vs.15.7 ± 3.3 U/L;P<.0001) whereas, patients with iron deficiency anemia had significantly higher levels than controls (28.1±5.8 U/L vs.15.7±3.3 U/L;P<.0001).In nonabusers, iron supplementation therapy significantly decreased CDT levels in patients with iron deficiency anemia (33.7±6.6 U/L vs.21.7± 5.2 U/L;P=.0007) while iron–depletion treatment significantly increased CDT levels in patients with GH (9.7 ± 2.0 U/L vs. 14.7 ± 4.0 U/L;P=.001).Alcohol abusers had a significant relationship between liver iron concentration (LIC)and the reciprocal of CDT (r=.65;P <.0001) while in nonabusers, there was a significant correlation between Tf and CDT (r=.72;P<.0001).In conclusion, CDT serum levels are markedly affected by the patient's iron status, with iron overload reducing its sensitivity in alcohol abusers and iron deficiency its specificity in nonabusers. CDT can be considered a reliable marker of alcohol abuse only when iron stores are normal.
- 1 March 1999
- Published by Wolters Kluwer Health in Hepatology
- Vol. 29 (3) , 658-663
Open AccessCarbohydrate–Deficient Transferrin, A Sensitive Marker of Chronic Alcohol Abuse, Is Highly Influenced by Body Iron
Carbohydrate–deficient transferrin(CDT) a microheterogeneous form of serum transferrin (Tf) has been proposed as the most reliable marker of chronic alcohol consumption, although unexplained false–positive and –negative results have been reported.We investigated whether body iron influenced CDT serum levels by studying alcohol abusers with or without iron overload and nonabusers with iron deficiency or iron overload caused by genetic hemochromatosis (GH).In alcohol abusers, CDT was significantly lower in the presence of iron overload than in the absence (24.6 ±16.5 U/L vs.33.3 ±11.7 U/L; P<.01) with false–negative results almost exclusively in patients with iron overload. Similarly, in nonabusers with GH, CDT was lower than in normal controls (9.6±2.2 U/L vs.15.7 ± 3.3 U/L;P<.0001) whereas, patients with iron deficiency anemia had significantly higher levels than controls (28.1±5.8 U/L vs.15.7±3.3 U/L;P<.0001).In nonabusers, iron supplementation therapy significantly decreased CDT levels in patients with iron deficiency anemia (33.7±6.6 U/L vs.21.7± 5.2 U/L;P=.0007) while iron–depletion treatment significantly increased CDT levels in patients with GH (9.7 ± 2.0 U/L vs. 14.7 ± 4.0 U/L;P=.001).Alcohol abusers had a significant relationship between liver iron concentration (LIC)and the reciprocal of CDT (r=.65;P <.0001) while in nonabusers, there was a significant correlation between Tf and CDT (r=.72;P<.0001).In conclusion, CDT serum levels are markedly affected by the patient's iron status, with iron overload reducing its sensitivity in alcohol abusers and iron deficiency its specificity in nonabusers. CDT can be considered a reliable marker of alcohol abuse only when iron stores are normal.