Kuo-Liang Chen

The ultimate goal of innovation is to improve performance. But if people’s needs and uses are ignored, innovation will only be a formality. In the past, research on innovation mostly focused on technology, processes, business models, services, and organizations. The measurement of innovation focuses on capabilities, processes, results, and methods, but there has always been a lack of pre-innovation measurements and tools. This study is the first to use the innovation use theory proposed by Christensen et al. combined with innovation types, and it uses the measurement focus on the early stage of innovation as a post-innovation performance prediction. This study collected 590 valid samples and used SPSS and the four-step BK method to conduct regression analysis and mediation tests. The empirical results obtained the following: (1) a confirmed model and scale of the innovation use theory; (2) that three constructs of innovation use theory have an impact on market performance; and (3) that innovation types acting as mediators will improve market performance. This study establishes an academic model of the innovation use theory to provide a clear scale tool for subsequent research. In practice, it can first measure the direction of innovation and performance prediction, providing managers with a reference when developing new products and applying market strategies.

Sustained growth and competitive advantage have always been the goals that enterprises strive to find and practice. This study uses the "positioning", "process" and "path" aspects of the dynamic capability perspective, and divides the stages according to "time sequence", to explore how enterprises adjust their organizational structure and practices in order to enhance their competitive advantages in a rapidly changing environment. Adapt to changing environments. This study uses a single case study to summarize the 35-year development process of Lion Tourism; summarizes the "events" that occurred in the "time sequence" into the perspective of dynamic capabilities, and explains how Lion Tourism responds to opportunities, advances deployment, and quickly adjusts Organizational structure and development strategy to ensure continuous growth and competitive advantage. Dynamic capabilities are more suitable for application in industries with rapidly changing environments. However, through the events experienced by the case companies, the theoretical model of the empirical dynamic capabilities’ viewpoint can be used as a basis for academic research models. Moreover, the case can be used as a reference for other travel industry peers. It can also determine the direction of industrial practice and provide a reference for managers' strategic operations. The paper concludes with theoretical and practical implications, dynamic capability testing, and future research recommendations.

Innovation has always been the driving force behind social progress. Enterprises will adopt different types of technological innovations according to their goals, resources, and market strategies. The industry generally pays attention to the development and application of electric vehicle technology innovation, but a single method may not be able to fully explain the innovation of electric vehicle technology. Furthermore, the results of technological innovation must be presented in terms of market benefits. Otherwise, insufficient cash flow will lead to innovation interruption. Therefore, this study uses the innovation matrix proposed by Rothaermel to classify the matrix formed by the market and technology. This study collects 43 periodicals and special publications published in 2010–2022 and 40 related electric vehicle literature that can be downloaded, summarizes the literature content according to the innovation matrix using literature bibliometric perspective and analysis, and obtains (1) most of the innovative technologies of electric vehicles originated from the extension of previous technologies and (2) batteries and power supplements that are the key items of electric vehicles. The proportion of radical technological innovation is relatively high, and they are also the main factors of market sales. Theoretically, this study can provide a basis for studying the combination of Rothaermel’s “innovation matrix” and Ansoff’s “expansion matrix”. In practice, this is the first time the electric vehicle industry is taken as an example, combining the two models, aiming at technology/production/market/performance for electric vehicle industry managers, the technological innovation direction, and the formulation of market strategy operations and advanced deployment.

ObjectiveTo assess the clinical characteristics, prognostic factors, and treatment outcomes of primary testicular lymphoma (PTL).Materials and MethodsWe reviewed the medical records of PTL patients diagnosed between January 2000 and May 2012 at four hospitals in Taiwan. The following data were collected and analyzed: patient age at diagnosis, B symptoms (fever, night sweats, and/or weight loss), tumor localization (diffuse or testis alone), tumor site (left, right, or bilateral), stage of disease, histological pattern, International Prognostic Index, treatment method and outcome, relapse, and survival time. Kaplan–Meier curves were constructed to assess the effects of various factors on patient survival.ResultsThirty patients with PTL were included in this study. The median age at diagnosis was 62.5 years (range: 19–89 years) and median overall survival (OS) was 44 months. The majority of the patients had unilateral lymphoma, stage I/II disease, and diffuse large B-cell lymphoma. An absence of B symptoms, limited disease stage, lymphoma localized to testis only, and orchidectomy were considered to be significantly favorable prognostic factors of OS (p < 0.05). The PTL treatment regimen varied among patients and included orchidectomy, chemotherapy, and/or radiotherapy. Interestingly, although 50% patients achieved complete remission (CR) post-treatment, relapse was observed in 42% patients during the follow-up period. Nonetheless, patients who initially underwent orchidectomy appeared to have a significantly better survival rate, whereas chemotherapy proved more advantageous for those with the diffuse-type PTL.ConclusionPTL is characterized by unique clinical features and prognostic factors. Despite differing treatment regimens, 50% of patients achieved CR. Patients with testicular localization who underwent orchidectomy may achieve better outcomes, whereas chemotherapy proved to be beneficial in those with diffuse-type PTL

Introduction: We examined whether endothelial cell therapy could restore normal erectile function in a diabetic rat model. We investigated the feasibility of using endothelial progenitor cells (EPC), obtained from peripheral blood, as a source of endothelial cells for therapy. Materials and Methods: EPC, isolated from peripheral blood of donor rats, were induced into an endothelial cell lineage. The culture expanded endothelial cells were labeled with red fluorescent dye and injected directly into the dysfunctional corpora of diabetic rats, and followed for up to 12 weeks. Erectile function was assessed by intracavernous pressure and the corporal tissues were retrieved for analyses. Results and Discussion: The progenitor and differentiated endothelial cell phenotypes were confirmed with cell specific antibodies. The animals injected with cells showed a substantial improvement in intracavernous pressure and their erectile function was restored to normal levels. Histologically, the implanted cells that were labeled with the fluorescent dye tracer PKH26 survived and integrated into the corporal tissue within the injected region. Conclusions: This study demonstrates that the EPC‐derived endothelial cells are able to restore normal erectile function in a diabetic rat model. This cell‐based technology may be a viable treatment modality for diabetic patients with erectile dysfunction.