Mandile Samantha Thobela
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Mandile Samantha Thobela has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Anthony Marius Smith
Affiliations National Institute for Communicable Diseases, Division of the National Health Laboratory Service, Johannesburg, South Africa, Department of Medical Microbiology, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa
1 shared publication - Heleen Du Plessis
National Institute for Communicable Diseases, Johannesburg, South Africa
1 shared publication - Karen Helena Keddy
Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Pretoria, South Africa
1 shared publication - Nevashan Govender
Division for Public Health Surveillance and Response, National Institute for Communicable Diseases, South Africa
1 shared publication - Shelina Moonsamy
Centre for Vaccines and Immunology, National Institute for Communicable Diseases, a division of the National Health Laboratory Service, Johannesburg, South Africa
1 shared publication
Latest Publications
- Open Access
- 31 July 2018
- Published by Journal of Infection in Developing Countries in The Journal of Infection in Developing Countries
- Vol. 12 (07) , 542-549
Detection of Campylobacter species in stool specimens from patients with symptoms of acute flaccid paralysis in South Africa
Introduction: Guillain-Barré Syndrome (GBS) is an autoimmune disease characterized by acute or subacute symmetrical ascending motor weakness, areflexia, and mild-to-moderate sensory abnormalities. Campylobacter jejuni is reported to be the most common bacterium associated with GBS cases. Despite the eradication of polio, the number of reported GBS cases remains considerably high in South Africa with the causative agents not being well described. Methodology: The aim of the study was to investigate the proportion of Campylobacter spp. detected in stool specimens from patients with symptoms of acute flaccid paralysis (AFP). Stool specimens from patients presenting with AFP, that were negative for polio and non-polio enteroviruses (NPENT), were processed and screened for the presence of Campylobacter spp. using quantitative PCR (qPCR). Results: Of the 512 stool specimens screened between October 2014 to December 2015, 12% (62/512) were positive for Campylobacter spp. Of these 62 Campylobacter infections: 77.4% (48/62) was C. jejuni; 19.4% (12/62) was Campylobacter coli; 3.2% (2/62) was mixed infections of C. jejuni and C. coli. Conclusions: True association of the disease with Campylobacter spp. will enable the proportion of Campylobacter-induced GBS to be better described in South Africa; this can only be done through systematic studies that include bacterial culture and serology together with molecular methodologies.
- 31 July 2018
- Published by Journal of Infection in Developing Countries in The Journal of Infection in Developing Countries
- Vol. 12 (07) , 542-549
Open AccessDetection of Campylobacter species in stool specimens from patients with symptoms of acute flaccid paralysis in South Africa
Introduction: Guillain-Barré Syndrome (GBS) is an autoimmune disease characterized by acute or subacute symmetrical ascending motor weakness, areflexia, and mild-to-moderate sensory abnormalities. Campylobacter jejuni is reported to be the most common bacterium associated with GBS cases. Despite the eradication of polio, the number of reported GBS cases remains considerably high in South Africa with the causative agents not being well described. Methodology: The aim of the study was to investigate the proportion of Campylobacter spp. detected in stool specimens from patients with symptoms of acute flaccid paralysis (AFP). Stool specimens from patients presenting with AFP, that were negative for polio and non-polio enteroviruses (NPENT), were processed and screened for the presence of Campylobacter spp. using quantitative PCR (qPCR). Results: Of the 512 stool specimens screened between October 2014 to December 2015, 12% (62/512) were positive for Campylobacter spp. Of these 62 Campylobacter infections: 77.4% (48/62) was C. jejuni; 19.4% (12/62) was Campylobacter coli; 3.2% (2/62) was mixed infections of C. jejuni and C. coli. Conclusions: True association of the disease with Campylobacter spp. will enable the proportion of Campylobacter-induced GBS to be better described in South Africa; this can only be done through systematic studies that include bacterial culture and serology together with molecular methodologies.