Silvia Ambrosii
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Silvia Ambrosii has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Angela D’alfonso
Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
1 shared publication - Ilaria Fantasia
Obstetrics & Gynecology Unit, Hospital San Salvatore, 67100 L’Aquila, Italy
1 shared publication - Manuela Ludovisi
Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
1 shared publication - Maurizio Guido
Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
1 shared publication - Sandra Cecconi
Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
1 shared publication - Sara Tabacco
Unit of Obstetrics and Gynecology, San Salvatore Hospital, 67100 L’Aquila, Italy
1 shared publication
Latest Publications
- Open Access
- 25 July 2023
- Published by MDPI AG in Current Issues in Molecular Biology
- Vol. 45 (8) , 6202-6215
Pre-Eclampsia: From Etiology and Molecular Mechanisms to Clinical Tools—A Review of the Literature
Pre-eclampsia is a severe pregnancy-related complication that manifests as a syndrome with multisystem involvement and damage. It has significantly grown in frequency during the past 30 years and could be considered as one of the major causes of maternal and fetal morbidity and mortality. However, the specific etiology and molecular mechanisms of pre-eclampsia are still poorly known and could have a variety of causes, such as altered angiogenesis, inflammations, maternal infections, obesity, metabolic disorders, gestational diabetes, and autoimmune diseases. Perhaps the most promising area under investigation is the imbalance of maternal angiogenic factors and its effects on vascular function, though studies in placental oxidative stress and maternal immune response have demonstrated intriguing findings. However, to determine the relative importance of each cause and the impact of actions aiming to significantly reduce the incidence of this illness, more research is needed. Moreover, it is necessary to better understand the etiologies of each subtype of pre-eclampsia as well as the pathophysiology of other major obstetrical syndromes to identify a clinical tool able to recognize patients at risk of pre-eclampsia early.
- 25 July 2023
- Published by MDPI AG in Current Issues in Molecular Biology
- Vol. 45 (8) , 6202-6215
Open AccessPre-Eclampsia: From Etiology and Molecular Mechanisms to Clinical Tools—A Review of the Literature
Pre-eclampsia is a severe pregnancy-related complication that manifests as a syndrome with multisystem involvement and damage. It has significantly grown in frequency during the past 30 years and could be considered as one of the major causes of maternal and fetal morbidity and mortality. However, the specific etiology and molecular mechanisms of pre-eclampsia are still poorly known and could have a variety of causes, such as altered angiogenesis, inflammations, maternal infections, obesity, metabolic disorders, gestational diabetes, and autoimmune diseases. Perhaps the most promising area under investigation is the imbalance of maternal angiogenic factors and its effects on vascular function, though studies in placental oxidative stress and maternal immune response have demonstrated intriguing findings. However, to determine the relative importance of each cause and the impact of actions aiming to significantly reduce the incidence of this illness, more research is needed. Moreover, it is necessary to better understand the etiologies of each subtype of pre-eclampsia as well as the pathophysiology of other major obstetrical syndromes to identify a clinical tool able to recognize patients at risk of pre-eclampsia early.