Maria Mentzelou

Aloysia citrodora (lemon verbena) is traditionally used to promote relaxation and sleep, but its clinical efficacy and underlying mechanisms remain uncertain. This narrative review critically evaluates its phytochemical constituents, potential sleep-regulatory mechanisms, preclinical and clinical evidence, pharmacokinetics, safety, and translational challenges. Literature published through 16 October 2026 was identified through PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar, supplemented by trial registries, regulatory documents, and reference screening. Evidence was qualitatively synthesized using methodological principles informed by SANRA and PRISMA-S. Aloysia citrodora contains phenylethanoid glycosides, particularly verbascoside, flavonoids, and volatile terpenoids. Preclinical investigations suggest sedative and sleep-modulating effects, with GABAergic and adenosinergic signaling representing plausible but incompletely validated mechanisms. Randomized clinical trials report improvements in subjective sleep quality and selected sleep-continuity parameters. However, objective improvements are modest, findings are heterogeneous, and human polysomnographic evidence is unavailable. Limited independent replication, uncertain systemic and central nervous system exposure, and insufficient long-term safety data restrict clinical interpretation. Aloysia citrodora may offer complementary benefits for selected sleep complaints, but evidence remains insufficient to establish efficacy for chronic insomnia. Independent, adequately powered trials using standardized preparations, prespecified clinically meaningful outcomes, objective sleep assessments, and integrated pharmacokinetic and safety evaluations are needed before broader clinical recommendations can be supported.

Background/Objectives: Perceived stress and sleep quality are increasingly recognized as important determinants of emotional eating (EE), particularly among university students who are frequently exposed to academic pressures, psychosocial challenges, and lifestyle disruptions. Both stress and sleep quality are closely interconnected, with elevated stress contributing to sleep disturbances and poor sleep further exacerbating psychological distress. The present study aims to simultaneously examine the independent contributions of perceived stress and sleep quality to EE while accounting for other relevant sociodemographic, lifestyle, and anthropometric factors. Methods: This cross-sectional study was conducted among 1297 university students recruited from 10 geographical regions of Greece. Data on sociodemographic characteristics, academic profile, lifestyle behaviors, and anthropometric parameters were collected using standardized and validated assessment instruments. Perceived stress was measured using the Perceived Stress Scale (PSS), while sleep quality was evaluated with the Pittsburgh Sleep Quality Index (PSQI). Emotional eating was assessed using the Emotional Eating subscale of the Three-Factor Eating Questionnaire–Revised 18 (TFEQ-R18), and participants were subsequently classified into tertiles corresponding to low, moderate, and high levels of emotional eating. Results: Perceived stress was independently associated with EE in the multivariable analysis. Compared with students reporting low levels of stress, those experiencing high perceived stress exhibited almost threefold greater odds of being classified in higher emotional eating categories (OR = 2.86; p = 0.0001). Likewise, participants with moderate perceived stress were approximately twice as likely to demonstrate elevated emotional eating levels relative to their low-stress counterparts (OR = 2.01; p = 0.0001). Sleep quality was also independently associated with EE after adjustment for potential confounding factors. Specifically, students characterized by inadequate sleep quality had more than three times the likelihood of belonging to higher emotional eating categories compared with those reporting satisfactory sleep quality (OR = 3.08; p = 0.0001). The multivariable model demonstrated good fit (Likelihood Ratio Test, p < 0.001), and the proportional odds assumption was satisfied (p = 0.46). Conclusions: These findings underscore the important role of psychological distress and sleep health in EE behavior, independent of other sociodemographic, academic, lifestyle, and anthropometric factors. Given the observed associations, interventions incorporating stress-management and sleep-improvement components may represent promising approaches for addressing emotional eating among university students; however, longitudinal and intervention studies are needed to establish causality. Future longitudinal and intervention studies are needed to establish causality among perceived stress, sleep quality, and emotional eating.

Background/Objectives: Natural products derived from plants, animals, and microorganisms have long been used as nutritional supplements and are increasingly recognized for their potential role in preventing and managing human diseases. This narrative review aims to summarize current evidence on the therapeutic relevance of natural products as dietary supplements across major disease categories and to highlight their mechanisms of action, clinical efficacy, and safety considerations. Methods: A narrative literature review was conducted using peer-reviewed articles, systematic reviews, and clinical studies focusing on natural products used as nutritional supplements in disease management. Relevant data were analyzed thematically, with emphasis on bioactive compounds, mechanisms of action, and evidence from preclinical and clinical research. Results: Natural products, particularly plant-derived polyphenols, flavonoids, terpenoids, omega-3 fatty acids, and probiotic-derived metabolites, exhibit diverse biological activities, including antioxidant, anti-inflammatory, immunomodulatory, and antimicrobial effects. Evidence suggests potential benefits in cardiovascular diseases, metabolic disorders such as diabetes and obesity, neurodegenerative conditions, certain cancers, gastrointestinal disorders, and infectious diseases. However, clinical efficacy varies depending on compound type, dosage, and formulation. Key limitations include low bioavailability, variability in composition, and insufficient large-scale clinical trials. Safety concerns such as herb–drug interactions and lack of standardization remain significant challenges. Conclusions: Natural products as nutritional supplements represent a promising adjunct strategy in the prevention and management of various human diseases. While preclinical and early clinical evidence is encouraging, stronger clinical validation, improved standardization, and clearer regulatory frameworks are required to fully integrate these agents into evidence-based medical practice.

Background/Objectives: Emotional eating (EE) is an emerging public health concern among university students, a population exposed to heightened academic demands, psychosocial stressors, and lifestyle changes that may promote maladaptive coping behaviors. EE has been linked to psychological distress, particularly depressive and anxiety symptoms, as well as sociodemographic, lifestyle, and anthropometric factors; however, findings remain heterogeneous and insufficiently integrated within comprehensive analytical frameworks. This study aimed to examine the association between EE and depressive and anxiety symptoms in university students, while assessing the independent contributions of sociodemographic, academic, lifestyle, and anthropometric determinants. Methods: A cross-sectional survey was performed among 1279 university students from 10 regions in Greece. Sociodemographic, academic, lifestyle, and anthropometric data were collected using validated instruments and standardized procedures. Depressive and anxiety symptoms were assessed by the use of the Beck Depression Inventory-II (BDI-II) and the six-item State-Trait Anxiety Inventory (STAI-6), respectively. EE was evaluated utilizing the EE subscale of the Three-Factor Eating Questionnaire–Revised 18 (TFEQ-R18). Multivariable ordinal logistic regression models were applied to examine independent associations. Results: In fully adjusted models, depressive and anxiety symptoms were the strongest correlates of higher EE levels, each associated with more than twofold increased odds. Female sex, Greek nationality, rural residence, enrollment in biomedical sciences, later academic years, and regular smoking were also positively associated with EE. Higher physical activity was inversely associated with EE levels. Overweight, obesity, and increased waist circumference and waist-to-hip ratio were consistently linked to higher EE, with several associations exceeding twofold increased odds. Conclusions: EE in university students is strongly associated with psychological distress and clusters with adverse lifestyle and anthropometric characteristics. These findings support the need for integrated interventions targeting mental health, lifestyle behaviors, and obesity-related risk factors. Longitudinal studies are warranted to clarify causal pathways and underlying mechanisms.

Background/Objectives: The multifaceted concept of body image (BI) refers to an individual’s attitudes and impressions of their body. Negative BI is associated with a number of harmful health consequences, including obesity, eating disorders, and symptoms of sadness. The contemporary digital era, marked by the dominance of platforms, has brought about a considerable transformation in the landscape of BI issues. This study’s goal is to compile and assess the connections between social media (SM) use, body weight, and BI in adult populations. Methods: This is a narrative review that comprehensively searches across multiple academic databases, such as PubMed, Medline, Scopus, Web of Science, and Google Scholar. Studies that used SM (online blogs, microblogs, content communities, or social networking sites) for engagement (e.g., sharing, commenting, liking) or image-related activities (e.g., viewing, posting, or engaging with images) with healthy adults (aged 18–70 years) of any body mass index (BMI kg/m²) met the inclusion criteria. Included were observational and experimental studies that examined habitual SM use. Only peer-reviewed works published in English between 2015 and 2025 met the search criteria. Results: The currently available findings suggest that obese people are more dissatisfied with their bodies than people of normal weight, and obese women are more dissatisfied with their bodies than their peers of normal weight. Furthermore, experimental studies have demonstrated that immediate BI is adversely affected by acute exposure to idealized social media photographs. Conclusions: Policies should support specialized training that emphasizes a holistic approach to health and puts functionality and health above attractiveness. This training is crucial for dispelling weight-related stigmas and enabling healthcare providers to offer compassionate treatment that supports mental and physical health. Future research must concentrate on internalization and social pressure or reinforcement because these subjects have not gotten as much emphasis in prior studies. Such mechanism research could help better contextualize the role of recently introduced SM items.

Background/Objectives: Emotional eating may be a consequence of acquired cue reactivity, a lack of control, or an inaccurate link between episodic overeating and negative affect, according to a new analysis of its standard measurement. This study was a controlled trial, which was designed to investigate the effect of personalized nutritional psychoeducation on emotional eating behavior. Methods: This study enrolled 95 participants (62 control group and 33 intervention group) who were randomized to treatment and assessed at 3-month follow-up. Over a period of 3 months, six thematic individual sessions were conducted with a frequency of every 15 days for the participants in the intervention group. The Three-Factor Eating Questionnaire (TFEQ) was used to assess feeding patterns and the manifestation of emotional food consumption in response to emotion. Results: At baseline, it appears that gender is positively related to TFEQ Emotional Score (β: 1.77 (random error: 0.57, p-value: 0.003). BMI (β: −0.11 (random error: 0.04, p-value: 0.003) and waist circumference are negatively related to the TFEQ Emotional Score. Conclusions: Although this study confirmed significant associations of emotional eating and gender, BMI, and waist circumference, the nutritional psychoeducation-based intervention did not exert the expected effects on emotional eating. More high-quality clinical trials need to further be designed to improve emotional eating behavior by applying relevant nutritional psychoeducation-based interventions.

Background/Objectives: The Mediterranean diet (MD) is well-studied for its health-promoting effects, while the factors influencing adherence in children remain an important research focus. This study examines the sociodemographic, maternal, perinatal, and lifestyle determinants associated with MD adherence among children aged 6–9 years in an effort to identify key predictors and their impact on long-term nutritional habits. Methods: This study recruited 4851 children from diverse Greek rural and urban regions. The mothers of the enrolled children completed relevant questionnaires on their children’s sociodemographics, perinatal outcomes, anthropometric parameters, breastfeeding practices, and physical activity status. The enrolled children completed the Children’s Depression Inventory (CDI) and the State–Trait Anxiety Inventory for Children—State (STAIC-S) form to assess the presence of depression and anxiety symptoms, respectively. The KIDMED score was used to assess the MD compliance of the enrolled children. Results: The outcomes demonstrated that higher maternal education and family economic status gravitated toward increased MD adherence (p = 0.0071, p ˂ 0.0001), while exclusive breastfeeding (p ˂ 0.0001) and higher physical activity levels (p = 0.0101) were strong predictive factors for MD adherence, highlighting the role of early-life interventions in shaping dietary habits. In contrast, cesarean delivery (p = 0.0173) and higher birth weight (p ˂ 0.0001) were linked to lower MD adherence, indicating potential metabolic and behavioral predispositions. Notably, higher MD adherence correlated with lower prevalence of depressive and anxiety symptoms (p ˂ 0.0001, p = 0.0001), underscoring its potential protective role in mental health. Conclusions: Our findings highlight a complex interplay between early-life and dietary behaviors, while further longitudinal studies are needed to establish causality and optimize evidence-based nutritional strategies and education for childhood health and well-being.

Background/Objectives: Mediterranean diet (MD) adherence is associated with a lower risk of developing several chronic diseases, including cardiovascular and metabolic disorders, cancer, and mental health diseases. University students are vulnerable to mental disorders that considerably affect their well-being and quality of life, which may be ascribed to the stressful environment during their academic studies. This cross-sectional survey designed to explore the relationship between MD compliance and perceived stress levels as well as sleep quality in a representative sample of university students from Greece. Methods: This survey assigned 5433 university students from 10 Greek regions. We used qualified questionnaires to examine the socio-demographics of the assigned students. Anthropometrics were determined by qualified methods. Validated questionnaires were used to determine diverse lifestyle factors like physical activity, perceived stress, sleep quality and MD adherence. Results: Concerning the primary objectives of this study, greater MD compliance was independently and significantly related to lower incidence of perceived stress and poor sleep quality in university students. As far as the secondary objectives of this study concern, greater MD compliance was independently and significantly related to female gender, rural type of residence, living with family, smoking, biomedicine studies, being normal weight, and having enhanced physical activity. Conclusions: This study reinforces the idea that healthy dietary patterns like MD could be a significant modifiable factor against perceived stress and poor sleep quality of university students. Based on this evidence, longitudinal studies should be performed to confirm whether MD can exert a causal effect on perceived stress and sleep quality.

Background/Objectives: The global prevalence of childhood obesity and overweight is steadily increasing, representing a pressing public health concern due to its persistence during adolescence and adulthood and its association with elevated morbidity and mortality risks. This cross-sectional study was designed to examine the potential association between overweight/obesity and the presence of depressive and anxiety symptoms in children aged 6 to 9 years. Methods: A total of 4098 children from various urban and rural regions in Greece were enrolled. Data was collected through maternal questionnaires capturing sociodemographic characteristics, perinatal outcomes, anthropometric measurements, breastfeeding practices, and physical activity levels. Children fulfilled the Children’s Depression Inventory (CDI) and the State-Trait Anxiety Inventory for Children—State form (STAIC-S) to evaluate symptoms of depression and anxiety, respectively. Results: Childhood overweight/obesity was independently and significantly associated with a more than two-fold increased likelihood of presenting depressive and anxiety symptoms. Childhood overweight/obesity was also significantly associated with maternal obesity, gestational weight gain, childbirth weight, mode of delivery, exclusive breastfeeding, and children’s physical activity. Conclusions: Overweight and obesity in children aged 6–9 years are significantly associated with an elevated risk of psychological distress, including depression and anxiety. These findings underscore the need for targeted public health policies and nutritional interventions aimed at promoting healthy lifestyle practices from early childhood. Educational efforts should also support new mothers in adopting and sustaining health-promoting behaviors to mitigate the long-term consequences of childhood obesity.

Background/Objectives: Emotional eating has been recognized as the tendency to eat in response to emotions, being recognized as a crucial risk factor for recurrent weight gain. Emotional eating has been interrelated with obesity/overweight, depression, anxiety, stress, and specific dietary habits at any stage of human life, negatively affecting human quality of life. The present study aims to summarize and explore the effects of emotional eating on children and how these effects may, in turn, influence their mental and physical health at the next stages of their lives. Methods: This is a narrative review of the presently existing clinical evidence concerning the impact of emotional eating in children. A comprehensive search of the most reliable online databases, e.g., PubMed, Scopus, Web of Science, and Google Scholar, was performed utilizing relevant keywords. Several inclusion and exclusion criteria were used to collect only cross-sectional, longitudinal, descriptive, and case–control surveys in children’s populations. Results: The current clinical evidence suggests that parental behavior may increase the risk of emotional eating in children. Several pieces of evidence also implied potential associations of emotional eating with overweight/obesity and mental disorders in children. Children’s dietary habits may also affect their risk of developing emotional eating. Conclusions: The prevalence of emotional eating is gradually increasing in the general population, and especially in children. Public strategies should be performed to educate parents to recognize potential emotional eating behaviors in their children and to adopt more healthy dietary habits for their children, even in the first months of their life. Educational programs should be organized in school communities to directly educate children on the benefits of healthy dietary patterns.