Hui Wang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Hui Wang has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Chengjian Li
Department of Pharmacy Shanghai Baoshan Luodian Hospital Shanghai China
1 shared publication Lei Lv
Department of Pharmacy, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, China
1 shared publication- Liang Zhao
Department of Pharmacy, Shanghai Baoshan Luodian Hospital, Shanghai 201908, China
1 shared publication Qing‐Qing Cao
Department of Pharmacy, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, China
1 shared publicationSi Wei Li
Department of Pharmaceutical Science, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA
1 shared publicationXian Qian
Department of Pharmacy, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, China
1 shared publication
Latest Publications
- 12 February 2018
- Published by Wiley in Biomedical Chromatography
- Vol. 32 (6) , e4189
A UPLC‐MS/MS method for simultaneous determination of five flavonoids from Stellera chamaejasme L. in rat plasma and its application to a pharmacokinetic study
Stellera chamaejasme L. has been used as a traditional Chinese medicine for the treatment of scabies, tinea, stubborn skin ulcers, chronic tracheitis, cancer and tuberculosis. A sensitive and selective ultra‐high liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS) method was developed and validated for the simultaneous determination of five flavonoids (stelleranol, chamaechromone, neochamaejasmin A, chamaejasmine and isochamaejasmin) of S. chamaejasme L. in rat plasma. Chromatographic separation was accomplished on an Agilent Poroshell 120 EC‐C18 column (2.1 × 100 mm, 2.7 μm) with gradient elution at a flow rate of 0.4 mL/min and the total analysis time was 7 min. The analytes were detected using multiple reaction monitoring in positive ionization mode. The samples were prepared by liquid–liquid extraction with ethyl acetate. The UPLC‐MS/MS method was validated for specificity, linearity, sensitivity, accuracy and precision, recovery, matrix effect and stability. The validated method exhibited good linearity (r ≥ 0.9956), and the lower limits of quantification ranged from 0.51 to 0.64 ng/mL for five flavonoids. The intra‐ and inter‐day precision were both S. chamaejasme L.
- 12 February 2018
- Published by Wiley in Biomedical Chromatography
- Vol. 32 (6) , e4189
A UPLC‐MS/MS method for simultaneous determination of five flavonoids from Stellera chamaejasme L. in rat plasma and its application to a pharmacokinetic study
Stellera chamaejasme L. has been used as a traditional Chinese medicine for the treatment of scabies, tinea, stubborn skin ulcers, chronic tracheitis, cancer and tuberculosis. A sensitive and selective ultra‐high liquid chromatography–tandem mass spectrometry (UPLC‐MS/MS) method was developed and validated for the simultaneous determination of five flavonoids (stelleranol, chamaechromone, neochamaejasmin A, chamaejasmine and isochamaejasmin) of S. chamaejasme L. in rat plasma. Chromatographic separation was accomplished on an Agilent Poroshell 120 EC‐C18 column (2.1 × 100 mm, 2.7 μm) with gradient elution at a flow rate of 0.4 mL/min and the total analysis time was 7 min. The analytes were detected using multiple reaction monitoring in positive ionization mode. The samples were prepared by liquid–liquid extraction with ethyl acetate. The UPLC‐MS/MS method was validated for specificity, linearity, sensitivity, accuracy and precision, recovery, matrix effect and stability. The validated method exhibited good linearity (r ≥ 0.9956), and the lower limits of quantification ranged from 0.51 to 0.64 ng/mL for five flavonoids. The intra‐ and inter‐day precision were both S. chamaejasme L.