Jianping Luo

Aims: Congestive heart failure (CHF) is closely associated with a decrease in cardiac output, and photoplethysmography (PPG) parameters can experimentally assess cardiac output. It is unclear whether there is an association between the change of bending photoplethysmography waveform area index (BPWAI) due to postural changes and CHF. Methods: We enrolled patients with suspected CHF. Patients completed physical examination, echocardiography, and pro‐brain natriuretic peptide (NT‐proBNP) test during their visit, and finger‐end PPG waveform area was measured in the sitting and bending positions using PPG. We then used logistic regression to analyze the association between BPWAI and CHF, and the receiver operating characteristic (ROC) curve and area under the curve (AUC) were used to assess the event risk association strength. Results: A total of 523 patients with suspected CHF were included in this study, of whom 291 (55.6%) had a final diagnosis of CHF. The association between BPWAI and CHF decreased 0.45‐fold for per 1 standard deviation increase in BPWAI (OR: 0.55 [95% CI, 0.44−0.68]). The AUC for BPWAI associated with CHF was 0.736 (95% CI, 0.689−0.782), with a corresponding sensitivity of 67.4% and specificity of 71.5%, and a cut‐off value of 0.85 for the diagnosis of CHF. Conclusion: When patients bend over, their PPG waveform area decreases, which is closely associated with patients with CHF. BPWAI is significantly associated with CHF and may serve as a potential associated indicator for CHF.

Systemic inflammation plays a key role in the pathogenesis of metabolic dysfunction-associated fatty liver disease (MAFLD). The red blood cell distribution width (RDW) and serum albumin levels are well-recognized biomarkers reflecting inflammatory and nutritional status. This study systematically investigates the association between the RDW-to-albumin ratio (RAR) and MAFLD, while further analyzing the dose-response relationship between RAR and the severity of hepatic steatosis (assessed by Controlled Attenuation Parameter, CAP) and fibrosis (assessed by Liver Stiffness Measurement, LSM). This cross-sectional analysis was based on data from the National Health and Nutrition Examination Survey (NHANES) 2017–2020. MAFLD was diagnosed in accordance with the 2020 global consensus, combining evidence of hepatic steatosis (via (CAP ≥ 248 dB/m detected by Vibration-Controlled Transient Elastography [VCTE] or ultrasound) and metabolic dysfunction. Multivariate weighted logistic regression models were used to analyze the association between RAR and MAFLD. Restricted Cubic Spline (RCS) analysis was employed to evaluate the dose-response relationships between RAR and CAP, as well as(LSM). Among the 4,453 participants, 2,482 were diagnosed with MAFLD. After full adjustment for confounding factors, each 1-unit increase in RAR was associated with a 69% higher prevalence of MAFLD (OR = 1.69, 95% CI: 1.24–2.31). When RAR was categorized into tertiles, compared with the lowest tertile (RAR < 3.10), the highest tertile (RAR > 3.40) was associated with a 66% increased prevalence of MAFLD (OR = 1.66, 95% CI: 1.09–2.53). RCS analysis revealed a significant linear dose-response relationship between RAR and MAFLD prevalence (P-overall < 0.001, P-nonlinear = 0.09), and significant nonlinear dose-response relationships between RAR and CAP (P-overall < 0.01, P-nonlinear = 0.004) as well as LSM (P-overall < 0.01, P-nonlinear = 0.05). CAP and LSM values increased significantly with elevated RAR. RAR is significantly positively associated with MAFLD prevalence in a linear manner among the U.S. population, and is closely correlated with the severity of hepatic steatosis and fibrosis.

Hyperthyroid heart disease (HHD) is characterized by cardiac remodeling and inflammation, yet targeted therapies remain limited. LCZ696 (sacubitril/valsart

Patients receiving doxorubicin (DOX) chemotherapy are susceptible to cardiac and brain tissue damage, with oxidative stress (OS) as the primary mechanism o

Background: While PM2.5’s cardiovascular effects are increasingly recognized, but bibliometric analyses of this research landscape remain limited. This study systematically evaluates global research trends, collaborations, and knowledge gaps. Methods: We analyzed 2618 publications (2004–2023) from Web of Science using VOSviewer and CiteSpace to assess outputs, collaborations, journals, and research hotspots. Results: Publications have grown steadily, dominated by China and the United States (82.4%). U.S. studies had higher citation impact. Harvard University was most productive institution. Key journals include Environmental Research and Circulation. Research hotspots included hypertension, inflammation, and lipid metabolism. Emerging frontiers involve PM2.5 constituents and gene–environment interactions. Conclusion: This bibliometric study highlights fragmentation and imbalances in PM2.5–cardiology research. Findings underscore the need for standardized exposure assessments, interdisciplinary collaboration, and targeted studies to guide policy and clinical practice.

Background: The long‐term effects of physical activity (PA) variability and cumulative PA (CPA) from young adulthood on cardiac remodeling remain controversial, and it is unclear whether these effects resemble those observed in elite athletes. Methods: A total of 1465 participants with recorded PA spanning a 30‐year period were included in this study. PA levels were assessed at 9 follow‐up visits using the CARDIA (Coronary Artery Risk Development in Young Adults) questionnaire. At year 30, left ventricular structure and function were evaluated using standardized echocardiography. CPA was calculated as the sum of average PA levels between consecutive visits multiplied by the corresponding intervisit intervals (in years). PA variability was quantified using average real variability (ARVPA). Additionally, participants were categorized into 4 groups: sustained low CPA and ARVPA group, low CPA and high ARVPA group, high CPA and low ARVPA group, and high CPA and high ARVPA group. Results: This study included 849 women (57.1%), 883 White participants (60.3%), and had a mean age of 55.3 years. Participants in the sustained high CPA group exhibited lower incidence of hypertension and diabetes. Multiple linear regression analyses showed that, compared with the sustained‐low‐CPA group, the sustained‐high‐CPA group and high‐CPA and high‐ARVPA group exhibited increased left ventricular end‐diastolic dimension index, and the high‐CPA and high‐ARVPA group revealed an increased left ventricular mass index and left atrial volume index. Conclusions: Our study suggests that high CPA, even when accompanied with high variability in PA levels, is associated with alterations in left ventricular structure in midlife.

Background: Increased arterial stiffness is an important marker of target organ damage in hypertension. Estimated pulse wave velocity (ePWV) is a noninvasive assessment of arterial stiffness based on blood pressure and age calculations, but its association with albuminuria, an early indicator of renal function impairment, still needs to be validated. The aim of this study was to investigate the association of ePWV with albuminuria and its dose–response properties in hypertensive patients.Methods: Hypertensive patients who attended the cardiology department of Ganzhou Hospital of Traditional Chinese Medicine in China from July 2024 to April 2025 were retrospectively enrolled. ePWV was calculated from systolic and diastolic blood pressure and age. Albuminuria was detected using a dipstick test. Logistic regression was used to analyze the association between ePWV and albuminuria, and dose–response relationship was assessed using restricted cubic spline (RCS).Results: A total of 761 hypertensive patients were included in the final analysis. The rate of positive albuminuria was 19.6%. High ePWV group (≥10.74 m/s) was associated with albuminuria compared to low ePWV group (OR = 2.79, 95% CI: 1.18–6.71). And for per 1-m/s increase in ePWV, the risk of ePWV association with albuminuria increased by 42% (OR = 1.42, 95% CI: 1.14–1.78). RCS analysis showed a linear dose–response relationship between ePWV and albuminuria (p non-linear >0.05).Conclusion: ePWV was independently associated with albuminuria in hypertensive patients with a linear dose–response relationship, suggesting that arterial stiffness may be a measurable risk factor for early renal injury, and that ePWV may serve as a simple tool for primary renal function assessment.

Background: Gut microbiota is strongly associated with hypertension. The Dietary Index of Gut Microbiota (DI-GM) is a newly proposed indicator of the diversity of gut microbiota in the diet. However, the relationship between DI-GM and hypertension is unclear. Methods: Data for this study were obtained from the National Health and Nutrition Examination Survey (2007–2020). Dietary data were used to calculate DI-GM and grouped into three tertile groups. Survey logistic regression and restricted cubic spline (RCS) were used to analyse the association between DI-GM and hypertension. Results: A total of 20 804 participants (age ≥20 years) were enrolled in the study. After adjusting for all covariates, the ORs for hypertension in the medium DI-GM group (second quartile, 4–5) and high DI-GM group (third quartile, >5) were 0.94 (95% CI: 0.83 to 1.06) and 0.87 (95% CI: 0.76 to 0.99) compared with the low DI-GM group (first quartile, <4). Additionally, results from the RCS analysis indicated a linear association between DI-GM and hypertension (p value for non-linearity=0.57). Conclusion: Our findings suggest that higher DI-GM dietary patterns are associated with a lower prevalence of hypertension in a representative sample of US adults. These results suggest that dietary patterns characterised by a higher DI-GM may represent a potential strategy for the prevention of hypertension.

Background: Dilated cardiomyopathy (DCM) is a cardiac disease with a poor prognosis of unclear etiology. Previous studies have shown that metabolism is associated with DCM. This study investigates the causal relationship between 1400 metabolites and DCM using a two-sample Mendelian randomization (MR) approach.Methods: The study utilized data from the OpenGWAS database, comprising 355,381 Europeans, including 1,444 DCM cases. A total of 1,400 metabolites were evaluated for their causal association with DCM. Instrumental variables (IVs) were selected based on genetic variation and used in the MR analysis. The primary analysis method was inverse variance weighting (IVW), supplemented by weighted median-based estimation and sensitivity analyses.Results: Of the 1,400 metabolites analyzed, 52 were identified as causally associated with DCM. The analysis revealed both positively and negatively correlated metabolites with DCM risk. Notable findings include the positive correlation of Tryptophan betaine and 5-methyluridine (ribothymidine) levels, and an inverse association of Myristoleate and Erythronate levels with DCM.Conclusions: The study provides significant insights into the metabolites potentially involved in the pathogenesis of DCM. These findings could pave the way for new therapeutic strategies and biomarker identification in DCM management.

Background: Autophagy is intimately associated with the development of cardiomyopathy and has received widespread attention in recent years. However, no relevant bibliometric analysis is reported at present. In order to summarize the research status of autophagy in cardiomyopathy and provide direction for future research, we conducted a comprehensive, detailed, and multidimensional bibliometric analysis of the literature published in this field from 2004 to 2023. Methods: All literatures related to autophagy in cardiomyopathy from 2004 to 2023 was collected from the Web of Science Core Collection, and annual papers, global publication trends, and proportion charts were analyzed and plotted using GraphPad price v8.0.2. In addition, CtieSpace [6.2.4R (64-bit) Advanced Edition] and VOSviewer (1.6.18 Edition) were used to analyze and visualize these data. Results: Two thousand two hundred seventy-nine papers about autophagy in cardiomyopathy were accessed in the Web of Science Core Collection over the last 20 years, comprising literatures from 70 countries and regions, 2208 institutions, and 10 810 authors. China contributes 56.32% of the total publications, substantially surpassing other countries, while the United States is ranked first in frequency of citations. Among the top 10 authors, six are from China, and four are from the United States. Air Force Military Medical University was the institution with the highest number of publications, while the Journal of Molecular and Cellular Cardiology (62 articles, 2.71% of the total) was the journal with the highest number of papers published in the field. Clustering of co-cited references and temporal clustering analysis showed that ferroptosis, hydrogen sulfide mitophagy, lipid peroxidation, oxidative stress, and SIRT1 are hot topics and trends in the field. The principal keywords are oxidative stress, heart, and heart failure. Conclusion: The research on autophagy in cardiomyopathy is in the developmental stage. This represents the first bibliometric analysis of autophagy in cardiomyopathy, revealing the current research hotspots and future research directions in this field.