Emese Orban

The benefic effects of lipid-lowering medication, in terms of reducing cardiovascular risk, should not to lead to ignoring of the potential adverse effects of this medication. Methods. The study used two quantitative, modern methods for analyzing bone tissue: 1D ¹H NMR diffusiometry and 2D T₂-T₂ exchange ¹H NMR relaxometry. The effects of simvastatin and fenofibrate on the Albinos Wistar rats’ bone tissue cytoarchitecture have been highlighted, both in terms of pore size and pore connectivity. The evaluations were dynamical, at 14, 16, and 18 weeks, respectively, in order to observe the effect of this medication in correlation with the duration of administration. Both fenofibrate and simvastatin decrease bone strength, and the effect was more significant with the increase of the duration of treatment. The negative effects on bone tissue are more significant with fenofibrate.

Introduction: The ongoing concern of the medical profession regarding chronic medication is related to increasing patient adherence and compliance to treatment and reducing medication side effects. In this respect, drugs represented by fixed-dose combinations of active substances within the same tablet have emerged. Such a principle can be extrapolated by following the potential beneficial effects that a chronic medication can have on chronic pathologies affecting different systems. Materials and Methods: The study included 48 female Albino Wistar rats, aged 16–18 months, which were divided into two groups: ovariectomized and non-ovariectomized rats. One batch of 12 non-ovariectomized rats received no treatment, becoming a control batch (NOVX-M). The ovariectomized (OVX) group was divided into 3 batches of 12 rats each: no treatment, control (OVX-M), fenofibrate-treated (OVX-F) and statin-treated (OVX-S) rats. At 12 weeks after ovariectomy, a femoral fracture occurred in the right hind limb of all animals included in the experiment To reveal the changes, at intervals of 2, 4, 6 and 8 weeks post-fracture, the proximal part of the femur was evaluated by NMR diffusiometry, which allows random motion of proton molecules expressed by self-diffusion coefficients, D, thus allowing analysis of the size and complexity of microscopic order cavities within biological structures, such as pores inside bones. Results: The effects of hypolipidemic medication in the absence of estrogen were evidenced, proving the beneficial effect that fenofibrate can have in preserving healthy tissue exposed to osteoporotic risk during the menopausal period. The effects of lipid-lowering medication are also influenced by the duration of administration. Conclusions: Osteoporosis and heart disease are two chronic pathologies that affect mainly female population in the second half of life, and proving the dual therapeutic potential of lipid-lowering medication may also have positive effects by increasing adherence and compliance to treatment.

Introduction. In the 2023-2024 cold season in Romania, there have been legislative changes regarding influenza immunization, with the aim of purchasing influenza vac­cine by the patient on the basis of a doctor’s prescription. Objective. To track the impact of the change in legislative norms regarding the flu immunization rate through family doctors in Mureş County, Romania. Materials and method. In 29 March 2024, we made a questionnaire, with 11 questions, at which 30 family physicians from Mureş County answered. Results. In terms of influenza im­mu­ni­zation of the surveyed doctors, 53% of the res­pon­dents were immunized and 47% of them did not opt for their own immunization. Regarding the rate of influenza vaccination, through legislative changes, 16.67% of doctors believe that the vaccination rate has increased, but 56.66% do not consider changes in the immunization rate, and at the opposite pole, 26.66% of the respondents were undecided. Conclusions. Legislative changes aimed at facilitating the population’s access to vaccination may influence the rate of flu immunization. Among the doctors interviewed, a reserved attitude towards flu immunization can be noted, which may impact the overall flu vaccination rate.