Mabrouk Al-Rasheedi

Objective: To compare the efficacy, safety, weight reduction and treatment adherence of oral versus subcutaneous semaglutide in adults with uncontrolled T2DM and obesity. Methods: A multicenter retrospective cohort study was conducted between January 2023 and January 2024. Adult patients (≥18 years) with T2DM (HbA1c ≥ 7%) and obesity (BMI ≥ 30) who received either oral or subcutaneous semaglutide were included. Demographic, clinical, and biochemical variables including body weight, BMI, HbA1c, side effects, and adherence were extracted from electronic medical records. Adverse effects were categorized by severity. Comparative analyses between groups used Chi-square and Mann Whitney U tests, with p0.05). The severity of adverse effects predominantly gastrointestinal symptoms such as nausea, vomiting, constipation, and diarrhea did not differ significantly between groups (p=0.994). However, dizziness was significantly more frequent in the subcutaneous group (p = 0.04). Adherence was markedly higher with oral semaglutide (p<0.05), with cost identified as the primary barrier among oral users, while subcutaneous users more frequently cited side effects, forgetfulness, and limited weight loss. Weight reduction was comparable at 3 months (p=0.23), but significantly greater with oral semaglutide at 6, 9, and 12 months (all p<0.01). Conversely, HbA1c reduction favored subcutaneous semaglutide at 3 and 6 months (p=0.03 and 0.02), although baseline glycemic control was similar. Conclusions: This study demonstrates that while subcutaneous semaglutide may provide a faster early HbA1c decline, oral semaglutide offers superior long-term weight reduction and significantly better adherence, likely attributable to easier administration. Both formulations exhibited comparable safety profiles.

High‐dose short‐term corticosteroid therapy is effective and produces favorable clinical outcome in patients with severe 2019‐nCoV infection who are candidates for mechanical ventilation with close monitor/ing for the adverse effect of corticosteroids.

Objective To report a series of eight cases of severe acute respiratory syndrome due to 2019-nCoV infection (Covid-19- Bilateral infiltration) who were successfully treated with high-dose short-term corticosteroid therapy.

Background The rapid and extensive spread of the COVID-19 pandemic has become a major cause of concern for both general public and healthcare profession. Aim of this study is to analyze and evaluate the awareness of both the general public and healthcare providers in Qassim region in Saudi Arabia. Method A cross-sectional study was conducted randomly in different shopping malls in the Qassim region from 10^th of February to 10^th of March, 2020. The structured questionnaire was used to gather information from participants.Result 130 participants have answered the designed questionnaire, out of which 67participants were males(58.5% ) and 54 were females(41.5% ).Overall, 129 (99%) out of the 130 participants are aware of COVID-19, and 116 (90%) have recognize it as a respiratory disease and all of them (100 %) have recognized it as a contagious disease. Participants of the age group 20-40 showed higher awareness level than other age groups (P = 0.005). Significant positive correlation between high risk groups recognition, reliable source of information, infection symptoms, disease spread prevention and COVID_19 available treatments. While the reliable source of information awareness was positively correlated with all other questions, except for the long-term complications..Conclusion General public and health care professionals from Qassim Region showed adequate awareness of COVID-19. However, there is a strong need to implement periodic educational interventions and training programs on infection control practices .

Background The rapid and extensive spread of the COVID-19 pandemic has become a major cause of concern for both general public and healthcare profession. Aim of this study is to analyze and evaluate the awareness of both the general public and healthcare providers in Qassim region in Saudi Arabia. Method A cross-sectional study was conducted randomly in different shopping malls in the Qassim region from 10^th of February to 10^th of March, 2020. The structured questionnaire was used to gather information from participants.Result130 participants have answered the designed questionnaire, out of which 67participants were males(58.5% ) and 54 were females(41.5% ).Overall, 129 (99%) out of the 130 participants are aware of COVID-19, and 116 (90%) have recognize it as a respiratory disease and all of them (100 %) have recognized it as a contagious disease. Participants of the age group 20-40 showed higher awareness level than other age groups (P = 0.005). Significant positive correlation between high risk groups recognition, reliable source of information, infection symptoms, disease spread prevention and COVID_19 available treatments. While the reliable source of information awareness was positively correlated with all other questions, except for the long-term complications.ConclusionGeneral public and health care professionals from Qassim Region showed adequate awareness of COVID-19. However, there is a strong need to implement periodic educational interventions and training programs on infection control practices.

Background: A significant growth in dietary supplement usage has occurred and this trend is particularly evident among females. This underlines the need to establish current knowledge levels among a female participant cohort based in the Aseer Region of the Kingdom of Saudi Arabia (KSA), along with determining the types of products being used and the typical reasons cited for their consumption. Methods: A total of 173 participants drawn from various age groups took part in this descriptive cross-sectional survey design. The survey was conducted over a three- month period from September to November 2019, using a structured online questionnaire. Results: The results of this research show that dietary supplement usage was highly prevalent among study participants. Young females (18-24 years) demonstrated significantly higher knowledge levels as compared to all other age groups (p<0.001 vs. other participants). Conclusion: This study has clearly shown that the participants in fact have a very varied range of knowledge, very often according to age, about the use of dietary supplements. 18-24-year-olds demonstrated higher levels of dietary supplement knowledge compared to the other age groups.