Bram P Prins
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Bram P Prins has a total of 126 co-authors. Here are the top co-authors by number of shared publications:
- Abbas Dehghan
Imperial College London
1 shared publication - Alexander Teumer
Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
1 shared publication - Alexandros M. Petrelis
DigitSole SAS, 54000 Nancy, France
1 shared publication - Anbupalam Thalamuthu
University of New South Wales
1 shared publication - Anders Hamsten
Cardiovascular Medicine, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden
1 shared publication - Angela Silveira
Department of Medicine Solna, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden
1 shared publication
Latest Publications
- Open Access
- 30 January 2021
- Published by Oxford University Press (OUP) in Human Molecular Genetics
- Vol. 30 (5) , 393-409
Genome-wide association study of circulating interleukin 6 levels identifies novel loci
Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (Pcombined = 1.8 × 10−11), HLA-DRB1/DRB5 rs660895 on Chr6p21 (Pcombined = 1.5 × 10−10) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (Pcombined = 1.2 × 10−122). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.
- 30 January 2021
- Published by Oxford University Press (OUP) in Human Molecular Genetics
- Vol. 30 (5) , 393-409
Open AccessGenome-wide association study of circulating interleukin 6 levels identifies novel loci
Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (Pcombined = 1.8 × 10−11), HLA-DRB1/DRB5 rs660895 on Chr6p21 (Pcombined = 1.5 × 10−10) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (Pcombined = 1.2 × 10−122). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.