Sungjin Park

Although large language models (LLMs) have demonstrated impressive reasoning capabilities across general domains, their effectiveness in real-world clinical practice remains limited. This is likely due to their insufficient exposure to real-world clinical data during training, as such data is typically not included due to privacy concerns. To address this, we propose enhancing the clinical reasoning capabilities of LLMs by leveraging real-world clinical data. We constructed reasoning-intensive questions from a nationwide sepsis registry and fine-tuned Phi-4 on these questions using reinforcement learning, resulting in C-Reason. C-Reason exhibited strong clinical reasoning capabilities on the in-domain test set, as evidenced by both quantitative metrics and expert evaluations. Furthermore, its enhanced reasoning capabilities generalized to a sepsis dataset involving different tasks and patient cohorts, an open-ended consultations on antibiotics use task, and other diseases. Future research should focus on training LLMs with large-scale, multi-disease clinical datasets to develop more powerful, general-purpose clinical reasoning models.

Although deep generative models have gained a lot of attention, most of the existing works are designed for unimodal generation. In this paper, we explore a new method for unconditional image-text pair generation. We design Multimodal Cross-Quantization VAE (MXQ-VAE), a novel vector quantizer for joint image-text representations, with which we discover that a joint image-text representation space is effective for semantically consistent image-text pair generation. To learn a multimodal semantic correlation in a quantized space, we combine VQ-VAE with a Transformer encoder and apply an input masking strategy. Specifically, MXQ-VAE accepts a masked image-text pair as input and learns a quantized joint representation space, so that the input can be converted to a unified code sequence, then we perform unconditional image-text pair generation with the code sequence. Extensive experiments show the correlation between the quantized joint space and the multimodal generation capability on synthetic and real-world datasets. In addition, we demonstrate the superiority of our approach in these two aspects over several baselines. The source code is publicly available at: https://github.com/ttumyche/MXQ-VAE.

We aim to separate the generative factors of data into two latent vectors in a variational autoencoder. One vector captures class factors relevant to target classification tasks, while the other vector captures style factors relevant to the remaining information. To learn the discrete class features, we introduce supervision using a small amount of labeled data, which can simply yet effectively reduce the effort required for hyperparameter tuning performed in existing unsupervised methods. Furthermore, we introduce a learning objective to encourage statistical independence between the vectors. We show that (i) this vector independence term exists within the result obtained on decomposing the evidence lower bound with multiple latent vectors, and (ii) encouraging such independence along with reducing the total correlation within the vectors enhances disentanglement performance. Experiments conducted on several image datasets demonstrate that the disentanglement achieved via our method can improve classification performance and generation controllability.