Beyza Ezgi Ortlek

Molecular communication (MC) provides a quantitative framework for analyzing information transfer within biological systems. This paper introduces a novel and comprehensive MC framework for the gut-brain axis (GBA) as a system of six coupled, nonlinear delay differential equations (DDEs). The proposed model defines a bidirectional feedback loop with a gut-to-brain inflammatory channel and a brain-to-gut neuroendocrine channel. Under prolonged stress, this feedback loop becomes self-perpetuating and drives the system into a pathological state. We evaluate the end-to-end channel across varying conditions using time-domain simulations, small-signal frequency-domain characterization, and an information-theoretic capacity analysis. At homeostasis, the system maintains stable circadian dynamics with higher information throughput, whereas sustained stress drives a shift to dysregulated hypercortisolism. In this pathological state, spectral efficiency decreases due to a narrowed effective bandwidth and a lower passband gain driven by neuroendocrine delays and saturating cytokine–hormone kinetics. These results quantify the impact of these signaling mechanisms on stability and information processing, elucidating the transition from healthy circadian rhythms to a persistent pathological state of hypercortisolism.

Molecular communication (MC) is a bio-inspired communication paradigm that utilizes molecules to transfer information and offers a robust framework for understanding biological signaling systems. This paper introduces a novel end-to-end MC framework for short-chain fatty acid (SCFA)-driven vagus nerve signaling within the gut-brain axis (GBA) to enhance our understanding of gut-brain communication mechanisms. SCFA molecules, produced by gut microbiota, serve as important biomarkers in physiological and psychological processes, including neurodegenerative and mental health disorders. The developed end-to-end model integrates SCFA binding to vagal afferent fibers, G protein-coupled receptor (GPCR)-mediated calcium signaling, and Hodgkin-Huxley-based action potential generation into a comprehensive vagus nerve signaling mechanism through GBA. Information-theoretic metrics such as mutual information and delay are used to evaluate the efficiency of this SCFA-driven signaling pathway model. Simulations demonstrate how molecular inputs translate into neural outputs, highlighting critical aspects that govern gut-brain communication. In this work, the integration of SCFA-driven signaling into the MC framework provides a novel perspective on gut-brain communication and paves the way for the development of innovative therapeutic advancements targeting neurological and psychiatric disorders.

Molecular communication (MC) is a bio-inspired communication paradigm that utilizes molecules to transfer information and offers a robust framework for understanding biological signaling systems. This paper introduces a novel end-to-end MC framework for short-chain fatty acid (SCFA)-driven vagus nerve signaling within the gut-brain axis (GBA) to enhance our understanding of gut-brain communication mechanisms. SCFA molecules, produced by gut microbiota, serve as important biomarkers in physiological and psychological processes, including neurodegenerative and mental health disorders. The developed end-to-end model integrates SCFA binding to vagal afferent fibers, G protein-coupled receptor (GPCR)-mediated calcium signaling, and Hodgkin-Huxley-based action potential generation into a comprehensive vagus nerve signaling mechanism through GBA. Information-theoretic metrics such as mutual information and delay are used to evaluate the efficiency of this SCFA-driven signaling pathway model. Simulations demonstrate how molecular inputs translate into neural outputs, highlighting critical aspects that govern gut-brain communication. In this work, the integration of SCFA-driven signaling into the MC framework provides a novel perspective on gut-brain communication and paves the way for the development of innovative therapeutic advancements targeting neurological and psychiatric disorders.

Humankind mimics the processes and strategies that nature has perfected and uses them as a model to address its problems. This has led to a new communication technology, molecular communication (MC), using molecules to encode, transmit, and receive information. Despite extensive research, an innate MC method found abundantly in nature—olfactory or odor communication—has not been thoroughly studied using information and communication technologies (ICT). Existing studies focus on digitizing this sense and developing actuators without examining odor-based information coding and MC principles, significantly limiting its application potential. Hence, cross-disciplinary research is needed to uncover the fundamentals of this unconventional communication modality from an ICT perspective. The ways of natural odor MC in nature need to be anatomized and engineered for end-to-end communication among humans and human-made things to enable several multi-sense augmented reality technologies reinforced with olfactory senses for novel applications and solutions in the Internet of Everything (IoE). This paper introduces odor-based molecular communication (OMC) and thoroughly examines olfactory systems, exploring odor communication in nature, including odor information, channels, reception, spatial perception, and cognitive functions. Additionally, a comprehensive comparison of various communication systems sets the foundation for further investigation. By highlighting OMC’s unique characteristics, advantages, and potential applications, this paper lays the groundwork for modeling end-to-end OMC channels, designing OMC transmitters and receivers, and developing innovative OMC techniques.

Molecular communication (MC) enables information transfer through molecules at the nano-scale. This paper presents new and optimized source coding (data compression) methods for MC. In a recent paper, prefix source coding was introduced into the field, through an MC-adapted version of the Huffman coding. We first show that while MC-adapted Huffman coding improves symbol error rate (SER), it does not always produce an optimal prefix codebook in terms of coding length and power. To address this, we propose optimal molecular prefix coding (MoPC*). The major result of this paper is the Molecular Arithmetic Coding (MoAC), which we derive based on an existing general construction principle for constrained arithmetic channel coding, equipping it with error correction and data compression capabilities for any finite source alphabet. We theoretically and practically show the superiority of MoAC to SAC, our another adaptation of arithmetic source coding to MC. However, MoAC’s unique decodability is limited by bit precision. Accordingly, a uniquely-decodable new coding scheme named Molecular Arithmetic with Prefix Coding (MoAPC) is introduced. On two nucleotide alphabets, we show that MoAPC has a better compression performance than MoPC*. MC simulation results demonstrate the effectiveness of the proposed methods.

The Internet of Bio-Nano Things (IoBNT) is a transformative communication framework characterized by heterogeneous networks comprising both biological entities and artificial micro/nano-scale devices, so-called Bio-Nano Things (BNTs), interfaced with conventional communication networks for enabling innovative biomedical and environmental applications. Realizing the potential of IoBNT requires the development of new and unconventional communication technologies, such as molecular communications, as well as the corresponding transceivers, bio-cyber interfacing technologies connecting the biochemical domain of IoBNT to the electromagnetic domain of conventional networks, and miniaturized energy harvesting and storage components for the continuous power supply to BNTs. Graphene and related materials (GRMs) exhibit exceptional electrical, optical, biochemical, and mechanical properties, rendering them ideal candidates for addressing the challenges posed by IoBNT. This perspective article highlights recent advancements in GRM-based device technologies that are promising for implementing the core components of IoBNT. By identifying the unique opportunities afforded by GRMs and aligning them with the practical challenges associated with IoBNT, particularly in the materials domain, our aim is to accelerate the transition of envisaged IoBNT applications from theoretical concepts to practical implementations while also uncovering new application areas for GRMs.