Nourhan Baraka
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Nourhan Baraka has a total of 3 co-authors. Here are the top co-authors by number of shared publications:
- Mohamed Mahmoud Elseweidy
Biochemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt
1 shared publication - Sahar E. El-Swefy
Department of Biochemistry, Faculty of Pharmacy, Delta University, Gamasa, Egypt
1 shared publication - Sally K. Hammad
Department of Biochemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt
1 shared publication
Latest Publications
- 1 June 2021
- Published by Egyptian Knowledge Bank in Zagazig Journal of Pharmaceutical Sciences
- Vol. 30 (1) , 17-32
Wnt signaling pathway as a regulator of bone formation and healing.
Bone is a mineralized structure that is mainly made of a matrix that supports the various types of bone cells; osteoblasts, osteoclasts, osteocytes and bone lining cells. Bone mass is preserved as a result of the balance between bone forming osteoblasts and bone resorbing osteoclasts, in a process known as bone remodeling. Bone remodeling process occurs mainly in three steps: resorption, reversal and formation. These steps are controlled locally and systemically by numerous regulatory factors. Among these regulatory factors, wingless-related MMTV integration site (Wnt) signaling pathway plays a significant role in maintainig bone mass as well as regulating many cellular processes. Based on whether β-catenin is involved or not, Wnt signaling is categorized into two main pathways; the canonical and the non-canonical pathways. The actions exerted by the Wnt signaling pathway are achieved when Wnt ligands bind to specific transmembrane receptors such as the Frizzled family (Frz) members and low density lipoprotein receptor-related proteins (LRPs) and are inhibited when these ligands or receptors bind to Wnt signaling inhibitors such as Wnt inhibitory factor 1 (WIF1), secreted Frizzled-related proteins (sFRPs), Dickkopf 1 (DKK1) and sclerostin. Improper synthesis of any of these ligands, receptors or inhibitors leads to disruption of different body functions and progression of various diseases including skeletal diseases. Therefore, the components of the Wnt signaling pathway can be targeted for developing novel therapeutic agents to manage different diseases.
- 1 June 2021
- Published by Egyptian Knowledge Bank in Zagazig Journal of Pharmaceutical Sciences
- Vol. 30 (1) , 17-32
Wnt signaling pathway as a regulator of bone formation and healing.
Bone is a mineralized structure that is mainly made of a matrix that supports the various types of bone cells; osteoblasts, osteoclasts, osteocytes and bone lining cells. Bone mass is preserved as a result of the balance between bone forming osteoblasts and bone resorbing osteoclasts, in a process known as bone remodeling. Bone remodeling process occurs mainly in three steps: resorption, reversal and formation. These steps are controlled locally and systemically by numerous regulatory factors. Among these regulatory factors, wingless-related MMTV integration site (Wnt) signaling pathway plays a significant role in maintainig bone mass as well as regulating many cellular processes. Based on whether β-catenin is involved or not, Wnt signaling is categorized into two main pathways; the canonical and the non-canonical pathways. The actions exerted by the Wnt signaling pathway are achieved when Wnt ligands bind to specific transmembrane receptors such as the Frizzled family (Frz) members and low density lipoprotein receptor-related proteins (LRPs) and are inhibited when these ligands or receptors bind to Wnt signaling inhibitors such as Wnt inhibitory factor 1 (WIF1), secreted Frizzled-related proteins (sFRPs), Dickkopf 1 (DKK1) and sclerostin. Improper synthesis of any of these ligands, receptors or inhibitors leads to disruption of different body functions and progression of various diseases including skeletal diseases. Therefore, the components of the Wnt signaling pathway can be targeted for developing novel therapeutic agents to manage different diseases.