Lei Sun
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Previous Organizations / Institutes
The organizations / institutes from the scholar's other articles in the past ten years
Research Subjects
Lei Sun has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
Hua Feng
1 shared publicationJing Sun
1 shared publicationLei Hu
1 shared publication- Min Jiang
Nanjing Tech University
1 shared publication - Ruocheng Zhao
State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211800, China
1 shared publication - Wenyong Liu
Key Laboratory of Biomechanics and Mechanobiology (Beihang University) Ministry of Education Key Laboratory of Innovation and Transformation of Advanced Medical Devices Ministry of Industry and Information Technology National Medical Innovation Platform for Industry‐Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering) School of Biological Science and Medical Engineering Beihang University Beijing China
1 shared publication
Latest Publications
- Open Access
Functional Polymer-Based Biomaterials for Corneal Tissue Engineering: An Indication-Guided Review of Design Trade-Offs
Corneal disease is a cause of vision loss worldwide, while conventional keratoplasty is constrained by limited donor tissue and immune rejection. This indication-guided review examines functional polymer platforms for corneal tissue engineering, including natural polymers, synthetic polymer networks and scaffolds, and hybrid polymer composites. It examines how molecular composition, crosslinking, architecture, surface functionalization, and fabrication influence hydrogels, films, fibrous scaffolds, injectable matrices, delivery systems, and polymeric keratoprosthetic components for epithelial, stromal, and endothelial contexts. Using an indication-guided design trade-off framework, the review compares these systems across optical performance, mechanical performance and surgical handling, mass transport and degradation behavior, biological function and tissue integration, host response, and manufacturability. Natural polymers can provide biological cues that support cell interactions, with limitations in mechanical robustness and compositional consistency. Synthetic polymers offer greater control of network properties and processing but often require biofunctionalization to support tissue integration. Hybrid constructs can distribute optical, structural, and therapeutic functions across components or regions, with added fabrication complexity. No material class is universally optimal, and polymer selection should be guided by the target corneal layer and clinical indication. Standardized evaluation, reproducible reporting of polymer composition and fabrication conditions, scalable manufacturing, and transparent reporting of evidence maturity are priorities for clinical translation.
Open AccessFunctional Polymer-Based Biomaterials for Corneal Tissue Engineering: An Indication-Guided Review of Design Trade-Offs
Corneal disease is a cause of vision loss worldwide, while conventional keratoplasty is constrained by limited donor tissue and immune rejection. This indication-guided review examines functional polymer platforms for corneal tissue engineering, including natural polymers, synthetic polymer networks and scaffolds, and hybrid polymer composites. It examines how molecular composition, crosslinking, architecture, surface functionalization, and fabrication influence hydrogels, films, fibrous scaffolds, injectable matrices, delivery systems, and polymeric keratoprosthetic components for epithelial, stromal, and endothelial contexts. Using an indication-guided design trade-off framework, the review compares these systems across optical performance, mechanical performance and surgical handling, mass transport and degradation behavior, biological function and tissue integration, host response, and manufacturability. Natural polymers can provide biological cues that support cell interactions, with limitations in mechanical robustness and compositional consistency. Synthetic polymers offer greater control of network properties and processing but often require biofunctionalization to support tissue integration. Hybrid constructs can distribute optical, structural, and therapeutic functions across components or regions, with added fabrication complexity. No material class is universally optimal, and polymer selection should be guided by the target corneal layer and clinical indication. Standardized evaluation, reproducible reporting of polymer composition and fabrication conditions, scalable manufacturing, and transparent reporting of evidence maturity are priorities for clinical translation.
- 1 December 2008
- Vol. 25 (6) , 1458-61
[Research progress of joint kinematics and kinetics].
The development process of joint kinematics and kinetics is expatiated from the aspects of technology and method. Firstly, the classical mechanics-based methods are introduced. Secondly, the computer assisted methods are analyzed from the technical aspects of video tracking, fluoroscopy and MR imaging separately. Then the assistance of robotic technique in this field is discussed. Finally the potential trend in the joint kinematics and kinetics is concluded.
- 1 December 2008
- Vol. 25 (6) , 1458-61
[Research progress of joint kinematics and kinetics].
The development process of joint kinematics and kinetics is expatiated from the aspects of technology and method. Firstly, the classical mechanics-based methods are introduced. Secondly, the computer assisted methods are analyzed from the technical aspects of video tracking, fluoroscopy and MR imaging separately. Then the assistance of robotic technique in this field is discussed. Finally the potential trend in the joint kinematics and kinetics is concluded.