Ann Schloithe
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Ann Schloithe has a total of 13 co-authors. Here are the top co-authors by number of shared publications:
- Angelique Levert-Mignon
Gastroesophageal Cancer Research Program, St. Vincent’s Centre for Applied Medical Research, Darlinghurst, NSW 2010, Australia
1 shared publication - Damian James Hussey
Flinders Health and Medical Research Institute—Cancer Program, Flinders University, Bedford Park, SA 5042, Australia
1 shared publication - David Ian Watson
Flinders Health and Medical Research Institute and College of Medicine and Public Health Flinders University Adelaide South Australia Australia
1 shared publication - George C. Mayne
Flinders Health and Medical Research Institute—Cancer Program, Flinders University, Bedford Park, SA 5042, Australia
1 shared publication - Isabell Bastian
Flinders Health and Medical Research Institute—Cancer Program, Flinders University, Bedford Park, SA 5042, Australia
1 shared publication - Lorraine Sheehan-Hennessy
Flinders Health and Medical Research Institute—Cancer Program, Flinders University, Bedford Park, SA 5042, Australia
1 shared publication
Latest Publications
- Open Access
- 11 April 2023
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 24 (8) , 7068
A Method for Increasing the Robustness of Stable Feature Selection for Biomarker Discovery in Molecular Medicine Developed Using Serum Small Extracellular Vesicle Associated miRNAs and the Barrett’s Oesophagus Disease Spectrum
The biomarker development field within molecular medicine remains limited by the methods that are available for building predictive models. We developed an efficient method for conservatively estimating confidence intervals for the cross validation-derived prediction errors of biomarker models. This new method was investigated for its ability to improve the capacity of our previously developed method, StaVarSel, for selecting stable biomarkers. Compared with the standard cross validation method, StaVarSel markedly improved the estimated generalisable predictive capacity of serum miRNA biomarkers for the detection of disease states that are at increased risk of progressing to oesophageal adenocarcinoma. The incorporation of our new method for conservatively estimating confidence intervals into StaVarSel resulted in the selection of less complex models with increased stability and improved or similar predictive capacities. The methods developed in this study have the potential to improve progress from biomarker discovery to biomarker driven translational research.
- 11 April 2023
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 24 (8) , 7068
Open AccessA Method for Increasing the Robustness of Stable Feature Selection for Biomarker Discovery in Molecular Medicine Developed Using Serum Small Extracellular Vesicle Associated miRNAs and the Barrett’s Oesophagus Disease Spectrum
The biomarker development field within molecular medicine remains limited by the methods that are available for building predictive models. We developed an efficient method for conservatively estimating confidence intervals for the cross validation-derived prediction errors of biomarker models. This new method was investigated for its ability to improve the capacity of our previously developed method, StaVarSel, for selecting stable biomarkers. Compared with the standard cross validation method, StaVarSel markedly improved the estimated generalisable predictive capacity of serum miRNA biomarkers for the detection of disease states that are at increased risk of progressing to oesophageal adenocarcinoma. The incorporation of our new method for conservatively estimating confidence intervals into StaVarSel resulted in the selection of less complex models with increased stability and improved or similar predictive capacities. The methods developed in this study have the potential to improve progress from biomarker discovery to biomarker driven translational research.