Saisai Xue
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Saisai Xue has a total of 10 co-authors. Here are the top co-authors by number of shared publications:
- Fengjiao Liu
Beijing Institute of Basic Medical Sciences, Beijing 100850, China
1 shared publication - Guochao Yang
Beijing Institute of Basic Medical Sciences, Beijing 100850, China
1 shared publication - Haitao Wu
Department of Neurobiology, Beijing Institute of Basic Medical Sciences, Beijing, China
1 shared publication - Hao Li
Beijing Institute of Basic Medical Sciences, Beijing 100850, China
1 shared publication - Ling-Ling Zhu
Institute of Basic Medical Sciences
1 shared publication - Liping Chen
Department of Neurobiology, Beijing Institute of Basic Medical Sciences, Beijing, China
1 shared publication
Latest Publications
- Open Access
- 26 March 2023
- Published by MDPI AG in Antioxidants
- Vol. 12 (4) , 806
O-GlcNAcylation Is Required for the Survival of Cerebellar Purkinje Cells by Inhibiting ROS Generation
Purkinje cells (PCs), as a unique type of neurons output from the cerebellar cortex, are essential for the development and physiological function of the cerebellum. However, the intricate mechanisms underlying the maintenance of Purkinje cells are unclear. The O-GlcNAcylation (O-GlcNAc) of proteins is an emerging regulator of brain function that maintains normal development and neuronal circuity. In this study, we demonstrate that the O-GlcNAc transferase (OGT) in PCs maintains the survival of PCs. Furthermore, a loss of OGT in PCs induces severe ataxia, extensor rigidity and posture abnormalities in mice. Mechanistically, OGT regulates the survival of PCs by inhibiting the generation of intracellular reactive oxygen species (ROS). These data reveal a critical role of O-GlcNAc signaling in the survival and maintenance of cerebellar PCs.
- 26 March 2023
- Published by MDPI AG in Antioxidants
- Vol. 12 (4) , 806
Open AccessO-GlcNAcylation Is Required for the Survival of Cerebellar Purkinje Cells by Inhibiting ROS Generation
Purkinje cells (PCs), as a unique type of neurons output from the cerebellar cortex, are essential for the development and physiological function of the cerebellum. However, the intricate mechanisms underlying the maintenance of Purkinje cells are unclear. The O-GlcNAcylation (O-GlcNAc) of proteins is an emerging regulator of brain function that maintains normal development and neuronal circuity. In this study, we demonstrate that the O-GlcNAc transferase (OGT) in PCs maintains the survival of PCs. Furthermore, a loss of OGT in PCs induces severe ataxia, extensor rigidity and posture abnormalities in mice. Mechanistically, OGT regulates the survival of PCs by inhibiting the generation of intracellular reactive oxygen species (ROS). These data reveal a critical role of O-GlcNAc signaling in the survival and maintenance of cerebellar PCs.