Junchen Liu
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Junchen Liu has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Hongyan Zhang
Beijing Key Lab of Plant Resource Research and Development, Institute of Cosmetic Regulatory Science, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China
1 shared publication - Huirong Zhang
Beijing Key Lab of Plant Resource Research and Development, Institute of Cosmetic Regulatory Science, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China
1 shared publication - Li Li
Beijing Key Laboratory of Plant Resources Research and Development, College of Light Industry Science and Engineering, Beijing Technology & Business University, Beijing 102488, China
1 shared publication - Miaomiao Guo
Beijing Key Laboratory of Plant Resources Research and Development, College of Light Industry Science and Engineering, Beijing Technology & Business University, Beijing 102488, China
1 shared publication - Wenrui Ma
Beijing Key Lab of Plant Resource Research and Development, Institute of Cosmetic Regulatory Science, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China
1 shared publication - Xianyao Meng
College of Chemistry and Materials Engineering, Beijing Technology & Business University, Beijing 100048, China
1 shared publication
Latest Publications
- Open Access
Anti-Inflammatory Activity of Panax notoginseng Flower Saponins Quantified Using LC/MS/MS
Panax notoginseng (Burk) F. H. Chen is a traditional Chinese medicinal and edible plant. However, Panax notoginseng flower (PNF) is rarely used. Therefore, the purpose of this study was to explore the main saponins and the anti-inflammatory bioactivity of PNF saponins (PNFS). We explored the regulation of cyclooxygenase 2 (COX–2), a key mediator of inflammatory pathways, in human keratinocyte cells treated with PNFS. A cell model of UVB-irradiation-induced inflammation was established to determine the influence of PNFS on inflammatory factors and their relationship with LL–37 expression. An enzyme-linked immunosorbent assay and Western blotting analysis were used to detect the production of inflammatory factors and LL37. Finally, liquid chromatography–tandem mass spectrometry was employed to quantify the main active components (ginsenosides Rb1, Rb2, Rb3, Rc, Rd, Re, Rg1, and notoginsenoside R1) in PNF. The results show that PNFS substantially inhibited COX–2 activity and downregulated the production of inflammatory factors, indicating that they can be used to reduce skin inflammation. PNFS also increased the expression of LL-37. The contents of ginsenosides Rb1, Rb2, Rb3, Rc, and Rd in PNF were much higher than those of Rg1, and notoginsenoside R1. This paper provides data in support of the application of PNF in cosmetics.
Open AccessAnti-Inflammatory Activity of Panax notoginseng Flower Saponins Quantified Using LC/MS/MS
Panax notoginseng (Burk) F. H. Chen is a traditional Chinese medicinal and edible plant. However, Panax notoginseng flower (PNF) is rarely used. Therefore, the purpose of this study was to explore the main saponins and the anti-inflammatory bioactivity of PNF saponins (PNFS). We explored the regulation of cyclooxygenase 2 (COX–2), a key mediator of inflammatory pathways, in human keratinocyte cells treated with PNFS. A cell model of UVB-irradiation-induced inflammation was established to determine the influence of PNFS on inflammatory factors and their relationship with LL–37 expression. An enzyme-linked immunosorbent assay and Western blotting analysis were used to detect the production of inflammatory factors and LL37. Finally, liquid chromatography–tandem mass spectrometry was employed to quantify the main active components (ginsenosides Rb1, Rb2, Rb3, Rc, Rd, Re, Rg1, and notoginsenoside R1) in PNF. The results show that PNFS substantially inhibited COX–2 activity and downregulated the production of inflammatory factors, indicating that they can be used to reduce skin inflammation. PNFS also increased the expression of LL-37. The contents of ginsenosides Rb1, Rb2, Rb3, Rc, and Rd in PNF were much higher than those of Rg1, and notoginsenoside R1. This paper provides data in support of the application of PNF in cosmetics.