Matthew T. DiMare

Supplemental Figure S5 shows distribution of barcoded clones into Louvain clusters.

Supplemental Figure S7 shows clone family gene signature set expression at drug tolerance.

Supplemental Figure S8 shows clone family contribution at drug resistance and sensitivity to drug combinations.

Supplemental Figure S1 shows barcode enrichment in drug treated cells, copy number segmentation, and xBC library cloning.

Supplemental Figure S3 shows Louvain clusters overlaid onto UMAP plots and contribution of cells by time point.

Supplemental Figure S6 shows clone family UMAPs, proportion change in response to drug, and gene signature set expression at untreated and acute drug treatment.

Legends for Supplemental Figures and Tables

Supplemental Figure S4 shows abundance of individual barcoded clones.

Supplemental Figure S2 shows UMAP plots, entropy analysis, quantification of barcode abundance, cell sensitivity to drug, and average gene signature set expression in sensitive vs tolerant clones.