Muthu Kesavan

Fire hazards pose a major challenge to wooden structures worldwide due to wood's inherent flammability and rapid flame spread, underscoring the urgent need for innovative materials and strategies to enhance fire resistance. In this context, a novel non‐covalent integration strategy was developed using pyridine‐substituted cyclotriphosphazene derivatives with Keggin‐type heteropoly tungstate anions ([PW ₁₂ O ₄₀ ] ³⁻ ), yielding multifunctional POM(W)–PN‐DP, POM(W)–PN‐TP, and POM(W)–PN‐HP materials with flame‐retardant and electrochemical properties. When incorporated into epoxy and applied to wood, the 10 wt% EP/POM–PN composite achieved a UL‐94 V‐0 rating and an LOI above 24 vol%, demonstrating enhanced fire resistance and mechanical strength through a synergistic P/N effect. Cone calorimeter tests further revealed significant reductions in both the total heat release rate and peak heat release rate. The synergistic interactions among POM(W)–PN‐DP and POM(W)–PN‐HP promoted the formation of a stable protective char layer during the combustion. Furthermore, the electrochemical performance of the synthesized materials was evaluated for supercapacitor applications using a standard three‐electrode system. POM(W)–PN‐HP and POM(W)–PN‐TP showed superior performance, with specific capacitances of 227.4 and 143.2 F/g, respectively, at 1 A/g. These POM–PN hybrids represent a promising class of multifunctional additives for fire‐safe and electrochemically active polymer systems.

The present study involved the synthesis of four beclomethasone dipropionate (BDP) derivatives with structural modifications at the C9, C11 and C21 carbon atoms and changing the substituents with halogen (Cl & Br) and alkyl moieties. The synthesis was achieved through a series of stepwise reactions and the derivatives were characterized by mass & 1H NMR spectral data and by HPLC analysis. In silico molecular docking studies demonstrated that all the synthesized BDP derivatives (5, 7, 9 and 12) exhibited favourable binding interactions with the glucocorticoid receptor (GR). The docking results revealed that all the BDP derivatives were in good agreement, particularly compound 5, which had strong binding affinity with the GR protein, comparable to the co-crystal. Based on the results, it was found that all BDP derivatives and its acts as drug-like molecules.