Huizhen Yang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Huizhen Yang has a total of 4 co-authors. Here are the top co-authors by number of shared publications:
- Jianwei Wang
School of Energy and Mechanical Engineering, Nanjing Normal University, Nanjing 210042, China
1 shared publication - Xiaole Chen
School of Energy and Mechanical Engineering, Nanjing Normal University, Nanjing 210023, China
1 shared publication - Yu Liu
School of Energy and Mechanical Engineering, Nanjing Normal University, Nanjing 210042, China
1 shared publication - Zhengqi Li
Hefei Leecan Pharmaceutical Co., Ltd., Hefei 230000, China
1 shared publication
Latest Publications
- Open Access
- 29 September 2023
- Published by MDPI AG in Atmosphere
- Vol. 14 (10) , 1509
Optimization of Vibrating Mesh Nebulizer Air Inlet Structure for Pulmonary Drug Delivery
The vibrating mesh nebulizer (VMN) has gained popularity for its compactness and noiselessness. This study investigates the impact of different air inlet structures on the deposition fraction (DF) of droplets generated by VMNs in an idealized mouth–throat (MT) airway model. Three homemade VMNs with semi-circular inlet, symmetrical four-inlet, and multiple-orifice inlet structures were evaluated through simulations and experiments. The changes in droplet DF of 0.9% w/v concentration of nebulized sodium chloride (NaCl) droplets as a function of inertial parameters were acquired under different inhalation flow conditions. Additionally, flow field distributions in models with different inlet structures were analyzed at a steady inspiratory flow rate of 15 L/min. The results indicate that optimizing the VMN’s air inlet structure significantly enhances droplet delivery efficiency. The multiple–orifice inlet structure outperformed the other designs, directing the airflow from the inlet position to the center of the mouthpiece and then into the oral cavity, achieving a DF of up to 20% at an inhalation flow rate of 15 L/min. The region of high airflow velocity between the mouthpiece and oral cavity proved to be a favorable VMN inlet optimization, reducing direct droplet–wall collisions and improving delivery efficiency. These findings offer insights for VMN design and optimization to enhance pulmonary drug delivery effectiveness and therapeutic outcomes.
- 29 September 2023
- Published by MDPI AG in Atmosphere
- Vol. 14 (10) , 1509
Open AccessOptimization of Vibrating Mesh Nebulizer Air Inlet Structure for Pulmonary Drug Delivery
The vibrating mesh nebulizer (VMN) has gained popularity for its compactness and noiselessness. This study investigates the impact of different air inlet structures on the deposition fraction (DF) of droplets generated by VMNs in an idealized mouth–throat (MT) airway model. Three homemade VMNs with semi-circular inlet, symmetrical four-inlet, and multiple-orifice inlet structures were evaluated through simulations and experiments. The changes in droplet DF of 0.9% w/v concentration of nebulized sodium chloride (NaCl) droplets as a function of inertial parameters were acquired under different inhalation flow conditions. Additionally, flow field distributions in models with different inlet structures were analyzed at a steady inspiratory flow rate of 15 L/min. The results indicate that optimizing the VMN’s air inlet structure significantly enhances droplet delivery efficiency. The multiple–orifice inlet structure outperformed the other designs, directing the airflow from the inlet position to the center of the mouthpiece and then into the oral cavity, achieving a DF of up to 20% at an inhalation flow rate of 15 L/min. The region of high airflow velocity between the mouthpiece and oral cavity proved to be a favorable VMN inlet optimization, reducing direct droplet–wall collisions and improving delivery efficiency. These findings offer insights for VMN design and optimization to enhance pulmonary drug delivery effectiveness and therapeutic outcomes.