Luana Marques Ribeiro

The Graded Prognostic Assessment (GPA) score has the best accuracy among prognostic scales for patients with brain metastases (BM). A wide range of GPA-derived scales have been established to different types of primary tumor BM. However, there is a high variability between them, and their characteristics have not been described altogether yet. We aim to summarize the features of the existent GPA-derived scales and to compare their predictor factors and their uses in clinical setting. Medline was searched from inception until January 2023 to identify studies related to the development, update, or validation of GPA. The initial search yielded 1,083 results. 16 original studies and 16 validation studies were included, comprising a total of 33,348 patients. 13 different scales were assessed, including: GPA, Diagnosis-Specific GPA, Extracranial Score, Lung-molGPA, Updated Renal GPA, Updated Gastrointestinal GPA, Modified Breast GPA, Integrated Melanoma GPA, Melanoma Mol GPA, Sarcoma GPA, Hepatocellular Carcinoma GPA, Colorectal Cancer GPA, and Uterine Cancer GPA. The most prevalent prognostic predictors were age, Karnofsky Performance Status, number of BM, and presence or absence of extracranial metastases. Treatment modalities consisted of whole brain radiation therapy, stereotactic radiosurgery, surgery, cranial radiotherapy, gamma knife radiosurgery, and BRAF inhibitor therapy. Median survival rates with no treatment and with a specific treatment ranged from 6.1 weeks to 33 months and from 3.1 to 21 months, respectively. Original GPA and GPA-derived scales are valid prognostic tools, but with heterogeneous survival results when compared to each other. More studies are needed to improve scientific evidence of these scales.

Anais da Jornada Científica de Medicina da Universidade Vila Velha (UVV) (978-85-5722-599-2) - Avaliação Do Perfil De Pacientes Usuários Crônicos De Inibidores Da Bomba De Prótons (Ibps) Atendidos No Centro De Especialidades Médicas E Atenção À Saúde (Cemas) Do Município De Vila Velha

Anais da Jornada Científica de Medicina da Universidade Vila Velha (UVV) (978-85-5722-599-2) - Avc Isquêmico Com Transformação Hemorrágica Em Paciente Com Hemofilia B Moderada E Trombofilia Hereditária Por Deficiência De Proteína S: Um Relato De Caso Raro

Anais da V Jornada Científica de Medicina da Universidade Vila Velha (978-65-5941-661-5) - Síndrome De Ramsay Hunt E Neuralgia Pós-Herpética Como Complicações De Herpes Zóster: Relato De Caso

Anais da V Jornada Científica de Medicina da Universidade Vila Velha (978-65-5941-661-5) - Primeira Trombectomia Mecânica Em Gestante No Brasil: Relato De Caso

Anais da V Jornada Científica de Medicina da Universidade Vila Velha (978-65-5941-661-5) - Disautonomia Cardiovascular Simpática Periférica Familiar: Relato De 3 Casos

A miosite viral é uma doença benigna, caracterizada por acometimento músculo-esquelético após infecções de vias aéreas superiores (IVAS) e que leva a dor e limitações transitórias de mobilidade em crianças. No caso relatado, o paciente do sexo masculino, 12 anos, portador de epilepsia, iniciou síndrome gripal que evoluiu com quadro clínico de dor importante em membros inferiores (MMII) e dificuldade de deambulação. Exames laboratoriais evidenciaram aumento da creatinoquinase, leucopenia e plaquetopenia. Após 10 dias, evoluiu clinicamente estável com regressão dos sintomas.

Context: Benign Acute Childhood Myositis (BACM) is a self-limited syndrome of acute myalgia prevalent in calf with impaired walking after Upper Respiratory Tract Infection. This report analyze the clinical condition and investigation of BACM case, by medical record. Case report: C.L.F.A., male, 12 years, in use of clobazam, sodium divalproate, topiramate and lamotrigine, started low back pain. One day after, presented headache, fever and nasal congestion. Reported convulsive febrile episodes. At following morning received Upper Respiratory Tract Infection diagnoses. Next day, maintained symptoms and developed thrombocytopenia. Discharged due to suspicion of dengue. After 24 hours, returned with improved thrombocytopenia, also with leukopenia. At 5th day, started pain in lower limbs and impaired walking. Due to muscle symptoms worsening and increased creatinophosphokinase, hospital admission were indicated. Laboratory tests found increased in creatinekinase (10,180 U/L), CKMB (129,6 U/L), leukopenia (2800/mm3 ) and thrombocytopenia (174,000 / mm3 ). Anti-HIV, anti- leptospirosis, dengue, Chikungunya and anti-HCV tests resulted negative. At the 6th hospitalization day, he was discharged virtue of muscle symptoms, leukocytosis and creatinekinase levels favorable progression. Conclusions: BACM has excellent prognosis and self-limited course, so outpatient care is feasible. The diagnosis is clinical. If neurological deficits, modified urine tests and rash, or symptoms duration longer than one week, differential diagnoses must be researched. Measure creatinekinase is important if pain or walking disability after viral episode. Early intervention avoids complications.

Anais da III Jornada de Medicina da Universidade Vila Velha (UVV) (978-65-990055-5-8) - Inibidor Da Bomba De Prótons Como Fator Causal Da Polipose Gástrica: Relato De Caso