Fany Iris Porras-Reyes
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Fany Iris Porras-Reyes has a total of 4 co-authors. Here are the top co-authors by number of shared publications:
- Alma Delia Campos-Parra
Instituto de Salud Pública, Universidad Veracruzana (UV), Av. Dr. Luis Castelazo Ayala s/n, Col. Industrial Ánimas, Xalapa 91190, Mexico
1 shared publication - David Sánchez-Marín
Posgrado en Ciencias Biológicas, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Ciudad de México 04360, Mexico
1 shared publication - Macrina Beatriz Silva-Cazares
Unidad Académica Multidisciplinaria Región Altiplano, Universidad Autónoma de San Luis Potosí, San Luis Potosi 78760, Mexico
1 shared publication Rebeca García-Román
Instituto de Salud Pública, Universidad Veracruzana (UV), Av. Dr Luis, Dr. Castelazo Ayala s/n, Col. Industrial Ánimas, Xalapa, Veracruz, C.P. 91190, México
1 shared publication
Latest Publications
- Open Access
- 1 May 2024
- Published by KEAI Publishing in Genes & Diseases
- Vol. 11 (3) , 101136
Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer
Long non-coding RNAs (lncRNAs) are non-coding RNAs longer than 200 nucleotides with dynamic regulatory functions. They interact with a wide range of molecules such as DNA, RNA, and proteins to modulate diverse cellular functions through several mechanisms and, if deregulated, they can lead to cancer development and progression. Recently, it has been described that lncRNAs are susceptible to form gene fusions with mRNAs or other lncRNAs, breaking the paradigm of gene fusions consisting mainly of protein-coding genes. However, their biological significance in the tumor phenotype is still uncertain. Therefore, their recent identification opens a new line of research to study their biological role in tumorigenesis, and their potential as biomarkers with clinical relevance or as therapeutic targets. The present study aimed to review the lncRNA fusions identified so far and to know which of them have been associated with a potential function. We address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window in cancer.
- 1 May 2024
- Published by KEAI Publishing in Genes & Diseases
- Vol. 11 (3) , 101136
Open AccessBreaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer
Long non-coding RNAs (lncRNAs) are non-coding RNAs longer than 200 nucleotides with dynamic regulatory functions. They interact with a wide range of molecules such as DNA, RNA, and proteins to modulate diverse cellular functions through several mechanisms and, if deregulated, they can lead to cancer development and progression. Recently, it has been described that lncRNAs are susceptible to form gene fusions with mRNAs or other lncRNAs, breaking the paradigm of gene fusions consisting mainly of protein-coding genes. However, their biological significance in the tumor phenotype is still uncertain. Therefore, their recent identification opens a new line of research to study their biological role in tumorigenesis, and their potential as biomarkers with clinical relevance or as therapeutic targets. The present study aimed to review the lncRNA fusions identified so far and to know which of them have been associated with a potential function. We address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window in cancer.