Chettipalayam Arunasalam Dhayanithi

Engineering linker structure in Mn-MOFs establishes a promising strategy for enhancing electrochemical sensing performance toward flutamide.

Preserving our environment is essential for sustaining life, yet contaminants like nitrofurantoin—a widely used antibacterial drug—pose significant risks to both ecological and human health. In the quest for a pollution‐free environment, the detection of such contaminants is critical. This study focuses on the development of monometallic and bimetallic MOFs, renowned for their properties, like high surface area and tunable characteristics, which make them ideal for electrochemical sensing applications. The preparation involves the hydrothermal synthesis of monometallic and bimetallic organic frameworks with aluminium (Al) and manganese (Mn) metals using 3,5‐pyridine dicarboxylic acid (PDC), with successful formation confirmed by XRD, FT‐IR, SEM, and XPS. The electrochemical sensing properties of these MOFs are studied by using CV and DPV. Various optimization studies are carried out to detect the optimal MOF, and it is found that AlMn‐PDC MOF/GCE shows high electrochemical performance, with the synergistic effect between Al and Mn enhancing the overall activity. Furthermore, real sample analysis confirmed the effectiveness of the sensor by achieving recoveries of 98.3% and 99.5% in milk and tap water, respectively. These findings highlight the potential of the AlMn‐PDC MOF/GCE as a highly sensitive and selective tool for nitrofurantoin detection, emphasizing the role of bimetallic MOFs in environmental monitoring applications.

A novel electrochemical sensor is constructed by modifying the glassy carbon electrode (GCE) using a binder-free metal–organic framework of V-shaped linker 4,4’oxybis(benzoic acid) (OBA) and various transition metals (M—Zn, Mn, or Ni). The hydrothermally synthesized M-OBA MOFs demonstrated superior electron transfer ability and enhanced electro-reduction behaviour, making it highly effective for metronidazole (MTZ) detection. The optimized sensor demonstrated a linear response from 0.04 to 122.18 µM, a low detection limit (LOD) of 0.009 µM, and high sensitivity (0.48 µA µM⁻¹ cm⁻²) using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The sensor also exhibited excellent selectivity in the presence of various ions, organic compounds, and other antibiotics. The Zn-OBA MOF sensor proves practical applicability for detecting MTZ in milk, honey, tap water, and MTZ tablets. Graphical Abstract