Cunkuan Shen
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Cunkuan Shen has a total of 26 co-authors. Here are the top co-authors by number of shared publications:
- Hua Yang
College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo 315100, China
2 shared publications - Aye Thida Maung
Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan
1 shared publication Hua Yang
1 shared publicationHuien Zhang
College of Biological and Environmental Sciences, Zhejiang Wanli University, Zhejiang, Ningbo 315100, China
1 shared publicationJiacheng Shi
College of Biological and Environmental Sciences, Zhejiang Wanli University, Zhejiang, Ningbo 315100, China; College of Food Science and Engineering, Ningbo University, Zhejiang, Ningbo 315832, China
1 shared publicationJiajun Feng
College of Biological and Environmental Sciences, Zhejiang Wanli University, Zhejiang, Ningbo 315100, China
1 shared publication
Latest Publications
- 25 May 2026
- Published by Elsevier in Food Chemistry
- Vol. 520, 149812
Inhibition of starch retrogradation in fermented rice cakes during simulated cold chain logistics
- 25 May 2026
- Published by Elsevier in Food Chemistry
- Vol. 520, 149812
Inhibition of starch retrogradation in fermented rice cakes during simulated cold chain logistics
- Open Access
Purification and Characterization of Immunomodulatory Peptides from Hydrolysates of Thunnus albacares Dark Muscle
Food-derived bioactive peptides have attracted considerable research interest and are increasingly utilized as functional ingredients in the food industry. In this study, the immunomodulatory peptides were isolated and purified from Thunnus albacares (T. albacares) enzymatic hydrolysates of muscles using gel chromatography and RP-HPLC, and their amino acid sequences were identified via LC-MS/MS. A total of six peptides were selected based on their affinity to toll-like receptors. Subsequently, these peptides were synthesized to confirm the immunomodulatory activities in vitro. Among all the tested peptides, two peptides, HDCDLLR and YGSVELDELGK, significantly enhanced cell proliferation and phagocytosis and increased the production of tumor necrosis factor-α (TNF-α), nitric oxide (NO), and interleukin-6 (IL-6). Molecular docking analysis indicated that these two peptides could stably bind to the receptors through hydrogen bonds and electrostatic and hydrophobic interactions. These findings suggested that peptides from enzymatic hydrolysates of T. albacares could be promising candidates for developing immunomodulatory agents in functional foods.
Open AccessPurification and Characterization of Immunomodulatory Peptides from Hydrolysates of Thunnus albacares Dark Muscle
Food-derived bioactive peptides have attracted considerable research interest and are increasingly utilized as functional ingredients in the food industry. In this study, the immunomodulatory peptides were isolated and purified from Thunnus albacares (T. albacares) enzymatic hydrolysates of muscles using gel chromatography and RP-HPLC, and their amino acid sequences were identified via LC-MS/MS. A total of six peptides were selected based on their affinity to toll-like receptors. Subsequently, these peptides were synthesized to confirm the immunomodulatory activities in vitro. Among all the tested peptides, two peptides, HDCDLLR and YGSVELDELGK, significantly enhanced cell proliferation and phagocytosis and increased the production of tumor necrosis factor-α (TNF-α), nitric oxide (NO), and interleukin-6 (IL-6). Molecular docking analysis indicated that these two peptides could stably bind to the receptors through hydrogen bonds and electrostatic and hydrophobic interactions. These findings suggested that peptides from enzymatic hydrolysates of T. albacares could be promising candidates for developing immunomodulatory agents in functional foods.