Sveta Silverman
Research Subjects
Research Interests
Sveta Silverman has a total of 4 co-authors. Here are the top co-authors by number of shared publications:
John Danyluk
Department of Laboratory Medicine and Pathology
1 shared publicationJune H. K. Hwang
Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada
1 shared publicationKelly D. Dabbs
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
1 shared publicationKen Alanen
Department of Laboratory Medicine and Pathology
1 shared publication
Latest Publications
- 10 September 2008
- Published by Wiley in Journal of Cutaneous Pathology
- Vol. 35 (10) , 955-959
Merkel cell carcinoma with squamous and sarcomatous differentiation
Merkel cell carcinoma is an aggressive neuroendocrine tumor historically thought to arise from neural crest-derived cutaneous neuroendocrine cells. Recent evidence supports an epidermal origin. We present a case of Merkel cell carcinoma arising on the upper arm of a 94-year-old woman that had multiple morphologic patterns: small cells typical of Merkel cell carcinoma, malignant cells with squamous differentiation and malignant poorly differentiated spindle cells. Subsequent metastatic disease in regional lymph nodes showed only the small cells and the malignant spindle cells. To our knowledge, this is the first case of Merkel cell carcinoma showing these three patterns of differentiation at first presentation. This morphology raises the possibility that Merkel cell carcinomas may arise from epidermal stem cells that can differentiate along different lines.
- 10 September 2008
- Published by Wiley in Journal of Cutaneous Pathology
- Vol. 35 (10) , 955-959
Merkel cell carcinoma with squamous and sarcomatous differentiation
Merkel cell carcinoma is an aggressive neuroendocrine tumor historically thought to arise from neural crest-derived cutaneous neuroendocrine cells. Recent evidence supports an epidermal origin. We present a case of Merkel cell carcinoma arising on the upper arm of a 94-year-old woman that had multiple morphologic patterns: small cells typical of Merkel cell carcinoma, malignant cells with squamous differentiation and malignant poorly differentiated spindle cells. Subsequent metastatic disease in regional lymph nodes showed only the small cells and the malignant spindle cells. To our knowledge, this is the first case of Merkel cell carcinoma showing these three patterns of differentiation at first presentation. This morphology raises the possibility that Merkel cell carcinomas may arise from epidermal stem cells that can differentiate along different lines.