Degong Jia
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Degong Jia has a total of 22 co-authors. Here are the top co-authors by number of shared publications:
- Shanshan Guo
Department of Nephrology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
3 shared publications - Zhixing Jia
Department of Surgery, Wen County People’s Hospital, Jiaozuo, Henan, China
2 shared publications - Bowen Xiong
Department of Ultrasound, Xinxiang Central Hospital, Xinxiang, 453000, China
1 shared publication - Dong Hou
Department of General Surgery, Second Division, The First Affiliated Hospital of Xinxiang Medical University, Weihui, 453100, China
1 shared publication - Huichao Xue
Department of General Surgery, Third Division, The First Affiliated Hospital of Xinxiang Medical University, Weihui, 453100, China
1 shared publication Jianping Gong
Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
1 shared publication
Latest Publications
- 1 September 2025
- Published by Bentham Science Publishers Ltd. in Current Medicinal Chemistry
- Vol. 32 (30) , 6603-6621
Identification of the Anti-ischemia-reperfusion Injury Effect of Baicalein from Scutellaria baicalensis Georgi in Liver Transplantation
Background: The complex etiology of Ischemia-Reperfusion Injury (IRI) induced by liver transplantation (LT) and the “one-target-focused” method limit the development of effective therapeutic interventions. We aimed to reveal the specific active ingredients and mechanisms involved in the Chinese herb Scutellaria baicalensis Georgi (SBG) in alleviating IRI in LT. Methods: The active ingredients and potential macromolecular targets of SBG were screened through related databases. The differentially expressed genes of LT were obtained from GSE151648. The protein-protein interaction network was constructed by the STRING database, and Cytoscape 3.7.1 was used to construct a compound-target-disease network. GO and KEGG enrichment analyses were performed on the DAVID database. Finally, the main active components of SBG and the corresponding mechanisms were verified in a donation after circulatory death (DCD) rat LT model. Results: Thirty-two active ingredients of SBG and their targets were identified, and a total of 38 intersection targets were obtained. GO function and KEGG pathway enrichment analyses demonstrated that the plasma membrane and its components play an important role. Molecular docking showed baicalein, the core component of SBG, had a strong binding ability to all hub targets. Next, in DCD rats, baicalein was proven to improve liver function, alleviate pathological injury and apoptosis, and increase the survival rate. Baicalein also significantly affected the expression of 7 hub genes. Furthermore, baicalein could inhibit ferroptosis by inhibiting phospholipid peroxidation. Conclusion: Baicalein, the main component of SBG, could alleviate IRI, affect the expression of hub genes, and inhibit ferroptosis in LT.
- 1 September 2025
- Published by Bentham Science Publishers Ltd. in Current Medicinal Chemistry
- Vol. 32 (30) , 6603-6621
Identification of the Anti-ischemia-reperfusion Injury Effect of Baicalein from Scutellaria baicalensis Georgi in Liver Transplantation
Background: The complex etiology of Ischemia-Reperfusion Injury (IRI) induced by liver transplantation (LT) and the “one-target-focused” method limit the development of effective therapeutic interventions. We aimed to reveal the specific active ingredients and mechanisms involved in the Chinese herb Scutellaria baicalensis Georgi (SBG) in alleviating IRI in LT. Methods: The active ingredients and potential macromolecular targets of SBG were screened through related databases. The differentially expressed genes of LT were obtained from GSE151648. The protein-protein interaction network was constructed by the STRING database, and Cytoscape 3.7.1 was used to construct a compound-target-disease network. GO and KEGG enrichment analyses were performed on the DAVID database. Finally, the main active components of SBG and the corresponding mechanisms were verified in a donation after circulatory death (DCD) rat LT model. Results: Thirty-two active ingredients of SBG and their targets were identified, and a total of 38 intersection targets were obtained. GO function and KEGG pathway enrichment analyses demonstrated that the plasma membrane and its components play an important role. Molecular docking showed baicalein, the core component of SBG, had a strong binding ability to all hub targets. Next, in DCD rats, baicalein was proven to improve liver function, alleviate pathological injury and apoptosis, and increase the survival rate. Baicalein also significantly affected the expression of 7 hub genes. Furthermore, baicalein could inhibit ferroptosis by inhibiting phospholipid peroxidation. Conclusion: Baicalein, the main component of SBG, could alleviate IRI, affect the expression of hub genes, and inhibit ferroptosis in LT.
- 25 July 2023
- Published by Wolters Kluwer Health in Liver Transplantation
- Vol. 29 (12) , E46-E47
Letter to the Editor: Redo hepatic artery reconstruction for thrombosis without retransplantation in 1355 adult living donor liver transplantations
An abstract is unavailable. This article is available as a PDF only.
- 25 July 2023
- Published by Wolters Kluwer Health in Liver Transplantation
- Vol. 29 (12) , E46-E47
Letter to the Editor: Redo hepatic artery reconstruction for thrombosis without retransplantation in 1355 adult living donor liver transplantations
An abstract is unavailable. This article is available as a PDF only.
- 8 May 2023
- Published by Wolters Kluwer Health in Liver Transplantation
- Vol. 29 (10) , E33
Letter to the Editor: Can ex-situ normothermic perfusion improve graft survival among donation after circulatory death liver allografts?
An abstract is unavailable. This article is available as a PDF only.
- 8 May 2023
- Published by Wolters Kluwer Health in Liver Transplantation
- Vol. 29 (10) , E33
Letter to the Editor: Can ex-situ normothermic perfusion improve graft survival among donation after circulatory death liver allografts?
An abstract is unavailable. This article is available as a PDF only.
- 11 April 2023
- Published by Wolters Kluwer Health in Liver Transplantation
- Vol. 29 (11) , E36-E37
Letter to the Editor: Validation of MELD 3.0 scoring system in East Asian patients with cirrhosis awaiting liver transplantation
An abstract is unavailable. This article is available as a PDF only.
- 11 April 2023
- Published by Wolters Kluwer Health in Liver Transplantation
- Vol. 29 (11) , E36-E37
Letter to the Editor: Validation of MELD 3.0 scoring system in East Asian patients with cirrhosis awaiting liver transplantation
An abstract is unavailable. This article is available as a PDF only.