Nick Deploey
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Previous Organizations / Institutes
The organizations / institutes from the scholar's other articles in the past ten years
Nick Deploey has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Frank Peelman
Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Flanders Institute for Biotechnology (VIB), Ghent University, Ghent, Belgium
2 shared publications - Inez Rogatsky
Hospital for Special Surgery Research Institute, The David Rosensweig Genomics Center, New York, NY, USA
1 shared publication - Karolien De Bosscher
VIB‐UGent Center for Medical Biotechnology (CMB) Ghent Belgium
1 shared publication - Laura Van Moortel
VIB Center for Medical Biotechnology, VIB, 9052 Ghent, Belgium
1 shared publication - Stefanie Maes
VIB‐UGent Center for Medical Biotechnology VIB Ghent Belgium
1 shared publication - Sven Eyckerman
VIB‐UGent Center for Medical Biotechnology VIB Ghent Belgium
1 shared publication
Latest Publications
- Open Access
- 13 November 2023
- Published by Elsevier in Cell Reports Methods
- Vol. 3 (11) , 100641
Deep mutational scanning of proteins in mammalian cells
- 13 November 2023
- Published by Elsevier in Cell Reports Methods
- Vol. 3 (11) , 100641
Open AccessDeep mutational scanning of proteins in mammalian cells
- Open Access
The Biologist’s Guide to the Glucocorticoid Receptor’s Structure
The glucocorticoid receptor α (GRα) is a member of the nuclear receptor superfamily and functions as a glucocorticoid (GC)-responsive transcription factor. GR can halt inflammation and kill off cancer cells, thus explaining the widespread use of glucocorticoids in the clinic. However, side effects and therapy resistance limit GR’s therapeutic potential, emphasizing the importance of resolving all of GR’s context-specific action mechanisms. Fortunately, the understanding of GR structure, conformation, and stoichiometry in the different GR-controlled biological pathways is now gradually increasing. This information will be crucial to close knowledge gaps on GR function. In this review, we focus on the various domains and mechanisms of action of GR, all from a structural perspective.
Open AccessThe Biologist’s Guide to the Glucocorticoid Receptor’s Structure
The glucocorticoid receptor α (GRα) is a member of the nuclear receptor superfamily and functions as a glucocorticoid (GC)-responsive transcription factor. GR can halt inflammation and kill off cancer cells, thus explaining the widespread use of glucocorticoids in the clinic. However, side effects and therapy resistance limit GR’s therapeutic potential, emphasizing the importance of resolving all of GR’s context-specific action mechanisms. Fortunately, the understanding of GR structure, conformation, and stoichiometry in the different GR-controlled biological pathways is now gradually increasing. This information will be crucial to close knowledge gaps on GR function. In this review, we focus on the various domains and mechanisms of action of GR, all from a structural perspective.