Emelie Nguyen
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Emelie Nguyen has a total of 11 co-authors. Here are the top co-authors by number of shared publications:
- Alan Arslan
Department of Population Health, New York University Grossman School of Medicine, New York, NY 10016, USA
1 shared publication - Emanuela Taioli
Department of Thoracic Surgery Icahn School of Medicine at Mount Sinai New York New York USA
1 shared publication - Joan Reibman
New York University School of Medicine New York New York USA
1 shared publication - Maria Cecilia Crisanti
Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA
1 shared publication - Matija Snuderl
Department of Pathology, NYU Grossman School of Medicine, New York, USA
1 shared publication - Muhammed Yilmaz
Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, USA
1 shared publication
Latest Publications
- Open Access
- 8 December 2023
- Published by MDPI AG in Epigenomes
- Vol. 7 (4) , 31
World Trade Center Exposure, DNA Methylation Changes, and Cancer: A Review of Current Evidence
Introduction: Known carcinogens in the dust and fumes from the destruction of the World Trade Center (WTC) towers on 9 November 2001 included metals, asbestos, and organic pollutants, which have been shown to modify epigenetic status. Epigenome-wide association analyses (EWAS) using uniform (Illumina) methodology have identified novel epigenetic profiles of WTC exposure. Methods: We reviewed all published data, comparing differentially methylated gene profiles identified in the prior EWAS studies of WTC exposure. This included DNA methylation changes in blood-derived DNA from cases of cancer-free “Survivors” and those with breast cancer, as well as tissue-derived DNA from “Responders” with prostate cancer. Emerging molecular pathways related to the observed DNA methylation changes in WTC-exposed groups were explored and summarized. Results: WTC dust exposure appears to be associated with DNA methylation changes across the genome. Notably, WTC dust exposure appears to be associated with increased global DNA methylation; direct dysregulation of cancer genes and pathways, including inflammation and immune system dysregulation; and endocrine system disruption, as well as disruption of cholesterol homeostasis and lipid metabolism. Conclusion: WTC dust exposure appears to be associated with biologically meaningful DNA methylation changes, with implications for carcinogenesis and development of other chronic diseases.
- 8 December 2023
- Published by MDPI AG in Epigenomes
- Vol. 7 (4) , 31
Open AccessWorld Trade Center Exposure, DNA Methylation Changes, and Cancer: A Review of Current Evidence
Introduction: Known carcinogens in the dust and fumes from the destruction of the World Trade Center (WTC) towers on 9 November 2001 included metals, asbestos, and organic pollutants, which have been shown to modify epigenetic status. Epigenome-wide association analyses (EWAS) using uniform (Illumina) methodology have identified novel epigenetic profiles of WTC exposure. Methods: We reviewed all published data, comparing differentially methylated gene profiles identified in the prior EWAS studies of WTC exposure. This included DNA methylation changes in blood-derived DNA from cases of cancer-free “Survivors” and those with breast cancer, as well as tissue-derived DNA from “Responders” with prostate cancer. Emerging molecular pathways related to the observed DNA methylation changes in WTC-exposed groups were explored and summarized. Results: WTC dust exposure appears to be associated with DNA methylation changes across the genome. Notably, WTC dust exposure appears to be associated with increased global DNA methylation; direct dysregulation of cancer genes and pathways, including inflammation and immune system dysregulation; and endocrine system disruption, as well as disruption of cholesterol homeostasis and lipid metabolism. Conclusion: WTC dust exposure appears to be associated with biologically meaningful DNA methylation changes, with implications for carcinogenesis and development of other chronic diseases.