Roberta Sciortino
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Roberta Sciortino has a total of 2 co-authors. Here are the top co-authors by number of shared publications:
- Giorgia Condrò
Department of Drug Sciences, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy
1 shared publication - Paola Perugini
Department of Drug Sciences, University of Pavia, 27100 Pavia, Italy
1 shared publication
Latest Publications
- Open Access
- 8 December 2023
- Published by MDPI AG in Pharmaceuticals
- Vol. 16 (12) , 1704
Squalene Peroxidation and Biophysical Parameters in Acne-Prone Skin: A Pilot “In Vivo” Study
Nowadays, acne vulgaris therapies are often unsuccessful. One of the responsible factors for the formation of comedones and inflammatory lesions could be the peroxidation of squalene, a hydrocarbon representing one of the major components of human sebum. This peroxidation is increased by solar irradiation. The purpose of this work was to set up an in vivo method for the extraction and quantification of squalene from acne skin and to correlate the results with biophysical skin parameters such as sebum amount, protein content and TEWL. Healthy volunteers were used as control. The results obtained demonstrated that acne-prone skin had a major quantity of squalene, and, in the stratum corneum area, its peroxide form is present. Moreover, Spearman’s rank correlation showed a positive correlation between sebum content and peroxide squalene and between porphyrin intensity and peroxide squalene.
- 8 December 2023
- Published by MDPI AG in Pharmaceuticals
- Vol. 16 (12) , 1704
Open AccessSqualene Peroxidation and Biophysical Parameters in Acne-Prone Skin: A Pilot “In Vivo” Study
Nowadays, acne vulgaris therapies are often unsuccessful. One of the responsible factors for the formation of comedones and inflammatory lesions could be the peroxidation of squalene, a hydrocarbon representing one of the major components of human sebum. This peroxidation is increased by solar irradiation. The purpose of this work was to set up an in vivo method for the extraction and quantification of squalene from acne skin and to correlate the results with biophysical skin parameters such as sebum amount, protein content and TEWL. Healthy volunteers were used as control. The results obtained demonstrated that acne-prone skin had a major quantity of squalene, and, in the stratum corneum area, its peroxide form is present. Moreover, Spearman’s rank correlation showed a positive correlation between sebum content and peroxide squalene and between porphyrin intensity and peroxide squalene.