Blanca Guadalupe Gómez-Sotelo
Research Subjects
Blanca Guadalupe Gómez-Sotelo has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- Adolfo Román-Román
Laboratorio de Investigación en Bacteriología, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39087, Guerrero, Mexico
1 shared publication - Berenice Illades-Aguiar
Laboratorio de Biomedicina Molecular, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Chilpancingo 39090, Guerrero, Mexico
1 shared publication - Daniel Hernández-Sotelo
Facultad de Ciencias Químico-Biológicas (FCQB), Universidad Autónoma de Guerrero (UAGro), Av. Lázaro Cárdenas S/N, Col. La Haciendita, Chilpancingo 39087, Guerrero, Mexico
1 shared publication - Eugenia Flores-Alfaro
Universidad Autónoma de Guerrero, México
1 shared publication - Evelyn Rivera-Toledo
Universidad Nacional Autónoma de México (UNAM), Facultad de Medicina, Departamento de Microbiología y Parasitología, Mexico City, Mexico
1 shared publication - Fredy Omar Beltrán-Anaya
Laboratorio de Genómica del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City, Mexico
1 shared publication
Latest Publications
- Open Access
- 12 December 2023
- Published by MDPI AG in Preprints.org
Single Infection and Dual Co-infection With Respiratory Viruses Affect Cytokine and Chemokine Expression in Acute Respiratory Illness Negative for SARS-CoV-2
During the COVID-19 pandemic, the circulation of non–SARS-CoV-2 respiratory viruses changed throughout the world. This study aimed to analyze the effect of respiratory syncytial virus (RSV), metapneumovirus (MPV), rhinovirus (RV), and parainfluenza (PIV)-3 single infection, dual co-infection, and viral load on cytokine and chemokine expression in 300 Mexican patients with ARIs negative for SARS-CoV-2. Molecular detection and viral load were performed by RT-qPCR. Cytokine and chemokine expression was determined in samples positive for single RSV, MPV, RV, or PIV-3 infection, and in the most frequent dual co-infections, by a cytokine panel using a magnetic-bead-based multiplex immunoassay. Of the patients positive for viral infection, 91.7% had a single infection and 8.3% had dual co-infections. In this study, RSV was the respiratory virus with the highest prevalence, and the most common dual co-infection was RV+RSV. On the other hand, RV infections had the highest viral loads compared to the other viruses detected. FGF basic, MIP-1α IL-8, IP-10, MCP-1, IFN-γ, and RANTES showed differential expression between single infections and dual co-infections compared to healthy patients. We report, for the first time, the circulation of non-SARS-CoV-2 viruses in the south of Mexico and the cytokine and chemokine profiles associated with these viruses.
- 12 December 2023
- Published by MDPI AG in Preprints.org
Open AccessSingle Infection and Dual Co-infection With Respiratory Viruses Affect Cytokine and Chemokine Expression in Acute Respiratory Illness Negative for SARS-CoV-2
During the COVID-19 pandemic, the circulation of non–SARS-CoV-2 respiratory viruses changed throughout the world. This study aimed to analyze the effect of respiratory syncytial virus (RSV), metapneumovirus (MPV), rhinovirus (RV), and parainfluenza (PIV)-3 single infection, dual co-infection, and viral load on cytokine and chemokine expression in 300 Mexican patients with ARIs negative for SARS-CoV-2. Molecular detection and viral load were performed by RT-qPCR. Cytokine and chemokine expression was determined in samples positive for single RSV, MPV, RV, or PIV-3 infection, and in the most frequent dual co-infections, by a cytokine panel using a magnetic-bead-based multiplex immunoassay. Of the patients positive for viral infection, 91.7% had a single infection and 8.3% had dual co-infections. In this study, RSV was the respiratory virus with the highest prevalence, and the most common dual co-infection was RV+RSV. On the other hand, RV infections had the highest viral loads compared to the other viruses detected. FGF basic, MIP-1α IL-8, IP-10, MCP-1, IFN-γ, and RANTES showed differential expression between single infections and dual co-infections compared to healthy patients. We report, for the first time, the circulation of non-SARS-CoV-2 viruses in the south of Mexico and the cytokine and chemokine profiles associated with these viruses.