Denisa Vladulescu
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Denisa Vladulescu has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Anca Angela Simionescu
Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
1 shared publication - Francesca Frincu
Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
1 shared publication - Lucian G. Scurtu
Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.; Department of Dermatology I, Colentina Clinical Hospital, Bucharest, Romania.
1 shared publication - Marco I. Popescu
Faculty of Medicine, “Titu Maiorescu” University, 040441 Bucharest, Romania
1 shared publication - Olga Simionescu
Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
1 shared publication
Latest Publications
- Top Cited PapersOpen Access
- 19 December 2023
- Published by MDPI AG in Biomedicines
- Vol. 12 (1) , 7
Platelet-Rich Plasma (PRP) in Dermatology: Cellular and Molecular Mechanisms of Action
Platelet-rich plasma (PRP) therapy has gained attention in the scientific field due to its potential regenerative effects and great benefit–risk ratio. This review extensively explores the most studied mechanisms of this therapy according to the etiopathogenesis of skin diseases: cellular proliferation, matrix formation, regulation of inflammation, angiogenesis, collagen synthesis, and the remodeling of new tissue. Moreover, it draws on newly reported and lesser-known effects of PRP: its anti-apoptotic effects, immunological suppression, decrease in melanin synthesis, anti-microbial effects, overexpression of miR-155, antioxidant effects, and their involved pathways. This work aims to provide a complete update for understanding PRP’s benefits and clinical relevance in wound healing, alopecia, pigmentary disorders, scars, rejuvenation, lichen sclerosus, and other inflammatory dermatoses, based on the current evidence. Furthermore, recent reports with novel indications for PRP therapy are highlighted, and new potential pathways correlated with the pathogenesis of skin diseases are explored.
- 19 December 2023
- Published by MDPI AG in Biomedicines
- Vol. 12 (1) , 7
Top Cited PapersOpen AccessPlatelet-Rich Plasma (PRP) in Dermatology: Cellular and Molecular Mechanisms of Action
Platelet-rich plasma (PRP) therapy has gained attention in the scientific field due to its potential regenerative effects and great benefit–risk ratio. This review extensively explores the most studied mechanisms of this therapy according to the etiopathogenesis of skin diseases: cellular proliferation, matrix formation, regulation of inflammation, angiogenesis, collagen synthesis, and the remodeling of new tissue. Moreover, it draws on newly reported and lesser-known effects of PRP: its anti-apoptotic effects, immunological suppression, decrease in melanin synthesis, anti-microbial effects, overexpression of miR-155, antioxidant effects, and their involved pathways. This work aims to provide a complete update for understanding PRP’s benefits and clinical relevance in wound healing, alopecia, pigmentary disorders, scars, rejuvenation, lichen sclerosus, and other inflammatory dermatoses, based on the current evidence. Furthermore, recent reports with novel indications for PRP therapy are highlighted, and new potential pathways correlated with the pathogenesis of skin diseases are explored.