Naoaki Kawahara
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Naoaki Kawahara has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Aina Yoshida
Graduate School of Sciences and Technology for Innovation, Tokushima University, 2-1 Minamijosanjima-Cho, Tokushima 770-8513, Japan
1 shared publication - Akihiro Tai
Graduate School of Technology, Industrial and Social Sciences, Tokushima University, 2-1 Minamijosanjima-cho, Tokushima 770-8513, Japan
1 shared publication - Asako Ono
Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, 5562 Nanatsuka-Cho, Shobara 727-0023, Japan
1 shared publication - Hideyuki Ito
Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki, Soja, Okayama 719-1197, Japan
1 shared publication - Mei Aburada
Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, 5562 Nanatsuka-Cho, Shobara 727-0023, Japan
1 shared publication - Shiori Mae
Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, 5562 Nanatsuka-Cho, Shobara 727-0023, Japan
1 shared publication
Latest Publications
- Open Access
Antiallergic Activity of 3-O-Dodecyl-l-ascorbic Acid
2-O-Alkyl-l-ascorbic acids and 3-O-alkyl-l-ascorbic acids were synthesized, and their degranulation inhibitory activities were evaluated. Among ascorbic acid derivatives with butyl, octyl, dodecyl, hexadecyl, and octadecyl groups introduced at the C-2 or C-3 positions, an AA derivative with a dodecyl group introduced at the C-3 position, 3-O-dodecyl-l-ascorbic acid (compound 8), showed the strongest inhibitory activity against antigen-stimulated degranulation. Compound 8 also inhibited calcium ionophore-stimulated degranulation. Compound 11, in which the hydroxyl group at the C-6 position of compound 8 was substituted with an amino group, and compound 12, in which the dodecyloxy group at the C-3 position of compound 8 was exchanged with a dodecylamino group, were synthesized, and these derivatives showed weaker inhibitory activity against antigen-stimulated degranulation than that of compound 8. In addition, orally administered compound 8 inhibited passive cutaneous anaphylaxis reactions in mice with a potency equal to that of oxatomide, an antiallergic agent. These results suggest that compound 8 may be a candidate for antiallergic treatment.
Open AccessAntiallergic Activity of 3-O-Dodecyl-l-ascorbic Acid
2-O-Alkyl-l-ascorbic acids and 3-O-alkyl-l-ascorbic acids were synthesized, and their degranulation inhibitory activities were evaluated. Among ascorbic acid derivatives with butyl, octyl, dodecyl, hexadecyl, and octadecyl groups introduced at the C-2 or C-3 positions, an AA derivative with a dodecyl group introduced at the C-3 position, 3-O-dodecyl-l-ascorbic acid (compound 8), showed the strongest inhibitory activity against antigen-stimulated degranulation. Compound 8 also inhibited calcium ionophore-stimulated degranulation. Compound 11, in which the hydroxyl group at the C-6 position of compound 8 was substituted with an amino group, and compound 12, in which the dodecyloxy group at the C-3 position of compound 8 was exchanged with a dodecylamino group, were synthesized, and these derivatives showed weaker inhibitory activity against antigen-stimulated degranulation than that of compound 8. In addition, orally administered compound 8 inhibited passive cutaneous anaphylaxis reactions in mice with a potency equal to that of oxatomide, an antiallergic agent. These results suggest that compound 8 may be a candidate for antiallergic treatment.