Long Lv

Accurate medical image segmentation is critical for early medical diagnosis. Most existing methods are based on U-shape structure and use element-wise addition or concatenation to fuse different level features progressively in decoder. However, both the two operations easily generate plenty of redundant information, which will weaken the complementarity between different level features, resulting in inaccurate localization and blurred edges of lesions. To address this challenge, we propose a general multi-scale in multi-scale subtraction network (M ² SNet) to finish diverse segmentation from medical image. Specifically, we first design a basic subtraction unit (SU) to produce the difference features between adjacent levels in encoder. Next, we expand the single-scale SU to the intra-layer multi-scale SU, which can provide the decoder with both pixel-level and structure-level difference information. Then, we pyramidally equip the multi-scale SUs at different levels with varying receptive fields, thereby achieving the inter-layer multi-scale feature aggregation and obtaining rich multi-scale difference information. In addition, we build a training-free network “LossNet” to comprehensively supervise the task-aware features from bottom layer to top layer, which drives our multi-scale subtraction network to capture the detailed and structural cues simultaneously. Without bells and whistles, our method performs favorably against most state-of-the-art methods under different evaluation metrics on eleven datasets of four different medical image segmentation tasks of diverse image modalities, including color colonoscopy imaging, ultrasound imaging, computed tomography (CT), and optical coherence tomography (OCT). The source code can be available at https://github.com/Xiaoqi-Zhao-DLUT/MSNet .

Multi-Modal Image Fusion (MMIF) aims to combine images from different modalities to produce fused images, retaining texture details and preserving significant information. Recently, some MMIF methods incorporate frequency domain information to enhance spatial features. However, these methods typically rely on simple serial or parallel spatial-frequency fusion without interaction. In this paper, we propose a novel Interactive Spatial-Frequency Fusion Mamba (ISFM) framework for MMIF. Specifically, we begin with a Modality-Specific Extractor (MSE) to extract features from different modalities. It models long-range dependencies across the image with linear computational complexity. To effectively leverage frequency information, we then propose a Multi-scale Frequency Fusion (MFF). It adaptively integrates low-frequency and high-frequency components across multiple scales, enabling robust representations of frequency features. More importantly, we further propose an Interactive Spatial-Frequency Fusion (ISF). It incorporates frequency features to guide spatial features across modalities, enhancing complementary representations. Extensive experiments are conducted on six MMIF datasets. The experimental results demonstrate that our ISFM can achieve better performances than other state-of-the-art methods. The source code is available at https://github.com/Namn23/ISFM.

Multi-Modal Image Fusion (MMIF) aims to integrate complementary image information from different modalities to produce informative images. Previous deep learning-based MMIF methods generally adopt Convolutional Neural Networks (CNNs) or Transformers for feature extraction. However, these methods deliver unsatisfactory performances due to the limited receptive field of CNNs and the high computational cost of Transformers. Recently, Mamba has demonstrated a powerful potential for modeling long-range dependencies with linear complexity, providing a promising solution to MMIF. Unfortunately, Mamba lacks full spatial and frequency perceptions, which are very important for MMIF. Moreover, employing Image Reconstruction (IR) as an auxiliary task has been proven beneficial for MMIF. However, a primary challenge is how to leverage IR efficiently and effectively. To address the above issues, we propose a novel framework named Spatial-Frequency Enhanced Mamba Fusion (SFMFusion) for MMIF. More specifically, we first propose a three-branch structure to couple MMIF and IR, which can retain complete contents from source images. Then, we propose the Spatial-Frequency Enhanced Mamba Block (SFMB), which can enhance Mamba in both spatial and frequency domains for comprehensive feature extraction. Finally, we propose the Dynamic Fusion Mamba Block (DFMB), which can be deployed across different branches for dynamic feature fusion. Extensive experiments show that our method achieves better results than most state-of-the-art methods on six MMIF datasets. The source code is available at https://github.com/SunHui1216/SFMFusion.

Accurate survival prediction is essential for guiding follow-up strategies in patients with cT1b renal cell carcinoma (RCC). Traditional AJCC TNM staging systems provide limited prognostic accuracy. Data from the SEER database were used, which included 22,426 patients with cT1b RCC who underwent surgical resection. The data were randomized into training and validation sets in a 7:3 ratioen, suring comparability using standardized mean differences (SMD < 0.1). A random survival forest (RSF) model was developed and compared with support vector machine (SVM) and extreme gradient boosting accelerated failure time (XGB-AFT) models. Model performance was assessed using AUC, sensitivity, specificity, and calibration, with 1000 bootstrap resamples. Shapley additive explanation (SHAP) values were calculated to explore variable importance and enhance interpretability. The RSF model achieved the highest discrimination for predicting 5- and 10-year overall survival (AUC: 0.746 and 0.742), outperforming AJCC TNM (AUC: 0.663 and 0.627), SVM, and XGB-AFT. The model demonstrated good calibration and clinical net benefit. SHAP analysis identified age, tumor size, grade, and marital status as the top contributors to survival prediction. The RSF model significantly improves survival prediction over conventional staging systems and other machine learning methods, with enhanced interpretability through SHAP analysis. While the lack of external validation and the use of overall survival (including non-cancer deaths) are limitations, the model shows strong potential for clinical implementation and may facilitate individualized follow-up planning. Future studies should validate the model prospectively and explore integration into clinical decision support systems.