Marwah Aljohani

This study investigates the synthesis process and characterization methods and evaluates the inhibition behavior of olanzapine (2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno-[2,3-b] 1,5]benzodiazepine (OLZ)) and its derivatives, such as 3-(2-methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e] [1,4]diazepin-10-yl) propenamide (OLZ1) and Ethyl 2-(2-methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepin-10 yl) acetate (OLZ2) for carbon steel (C1018) in a 1 M HCl acidic solution. Fourier Transform Infrared Spectroscopy (FTIR) and Nuclear Magnetic Resonance (NMR) were employed to verify their molecular structures and functional groups, which characterized the derivatives after synthesis. Their corrosion inhibition potential for C1018 steel in acidic media was estimated by weight loss (WL) and electrochemical techniques, such as electrochemical impedance spectroscopy (EIS), linear polarization resistance (LPR), and potentiodynamic polarization (PDP), accompanied by surface analysis methods. The findings revealed that all three derivatives demonstrated exceptional inhibition performance, achieving maximum efficiencies of 88.83%, 91.20%, and 91.82% for OLZ, OLZ1, and OLZ2 at 300 ppm, respectively. Weight loss experiments across different temperatures further explored their inhibitory behavior. Although inhibition efficiency decreased with a temperature increase to 318 K, the derivatives still displayed notable performance, with maximum efficiencies of 74.75% for OLZ, 81.63% for OLZ1, and 79.44% for OLZ2. Polarization studies identified the corrosion inhibition mechanisms as an anodic type. Surface characterization of the C1018 steel coupons, both with and without the inhibitors, was performed using FTIR and scanning electron microscopy (SEM) combined with energy-dispersive X-ray spectroscopy (EDX). These analyses indicated the creation of a protective inhibitor layer on the carbon steel surface, reducing corrosion in the acidic environment. Overall, this study underscores the potential of these drug derivatives as corrosion inhibitors, combining structural insights and performance assessments to support their industrial application.

This study investigates the synthesis process, characterization methods and evaluates the inhibition behavior of Olanzapine derivatives (OLZ, OLZ1, and OLZ2) for carbon steel (C1018) in a 1 M HCl acidic solution. Fourier Transform Infrared Spectroscopy (FTIR) and Nuclear Magnetic Resonance (NMR) to verify their molecular structures and functional groups, which characterized the derivatives after synthesis. Their corrosion inhibition potential for C1018 steel in acidic media was estimated by weight-loss (WL) and electrochemical techniques (EIS, LPR, and PDP), accompanied by surface analysis methods. The findings revealed that all three derivatives demonstrated exceptional inhibition performance, achieving maximum efficiencies of 88.83%, 91.20%, and 91.82% for OLZ, OLZ1, and OLZ2 at 300 ppm, respectively. Weight-loss experiments across different temperatures further explored their inhibitory behavior. Although inhibition efficiency decreased with a temperature increase to 318 K, the derivatives still displayed notable performance, with maximum efficiencies of 74.75% for OLZ, 81.63% for OLZ1, and 79.44% for OLZ2. Polarization studies identified the corrosion inhibition mechanisms as anodic type. Surface characterization of the C1018 steel coupons, both with and without the inhibitors, was performed using FTIR, scanning electron microscopy (SEM), combined with energy-dispersive X-ray spectroscopy (EDX). These analyses indicated the creation of a protective inhibitor layer on the carbon steel surface, reducing corrosion in the acidic environment. Overall, the study underscores the potential of these drug derivatives as green corrosion inhibitors, combining structural insights and performance assessments to support their industrial application.

Formaldehyde, sulfuric acid and salicylic acid were combined to create a 3,3′-methylenebis(2-hydroxybenzoic acid) (MHB) ligand, which was subsequently permitted to bind with zinc(II) ions. The ligand and its zinc(II) complex (Zn–MHB) have been described by a combination of elemental analyses, spectral analyses (UV–Vis, IR, MS and NMR), XRD, TEM, as well as TGA measurement. The ligand has been suggested to coordinate to the zinc center in a tetradentate manner forming the binuclear tetrahedral complex. An X-ray analysis indicated a considerable difference between MHB (crystalline) and Zn–MHB (amorphous). The UV–Vis spectra were used to determine the optical properties such as bandgap, refractive index, optical conductivity and penetration depth. The possibility of employing the samples for optoelectronic applications was indicated from the band gap values which underlie the range of semiconductors. TEM revealed the spherical shapes and mutation of ligand particles into the nano-scale by complexation. The antimicrobial potential of the MHB towards Gram-positive and Gram-negative bacterial growths has been investigated. The results suggested that it would be possible to employ MHB to prevent bacterial development, particularly that of salmonella typhimurium. The cytotoxicity of the MHB was assessed against two types of mammalian cells: VERO (the kidney of an African green monkey) and HFB4 (human skin melanocytes). Lower sensitivity was observed in VERO cells.

Formaldehyde, sulfuric acid and salicylic acid were combined to create 3,3’-methylenebis[2-hydroxybenzoic acid] (MHB) ligand, which was subsequently permitted to bind with zinc ions. The ligand and its zinc (II) complex (Zn-MHB) have been described by a combination of elemental analyses, spectral (UV-Vis, IR, MS, NMR), XRD, TEM as well as TGA measurement. The ligand has been suggested to coordinate to the zinc center in tetradentate manner forming binuclear tetrahedral complex. An X-ray analysis indicated a considerable difference between MHB (crystalline) and Zn-MHB (amorphous). UV-Vis spectra were used to determine the optical properties such as bandgap, refractive index, optical conductivity and penetration depth. Possibility of employing the samples for optoelectronic applications was indicated from the band gap values which underlie the range of semiconductors. TEM revealed spherical shapes and mutation of ligand particles into nano-scale by complexation. The antimicrobial potential of the MHB towards gram-positive and negative bacterial growths has been investigated. The results suggested that it would be possible to employ MHB to stop bacterial development, particularly salmonella typhimurium. Cytotoxicity of the MHB was assessed against two types of mammalian cells: VERO (the kidney of an African green monkey) and HFB4 (human skin melanocytes). Lower sensitivity was observed in VERO cells.