King Bwaila
King Bwaila has a total of 13 co-authors. Here are the top co-authors by number of shared publications:
Alhassan Mahama
1 shared publication- Amr Salah Abouzied
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia
1 shared publication - Bonface Mwamatope
Basic Science Department Faculty of Agriculture Lilongwe University of Agriculture and Natural Resources Lilongwe Malawi
1 shared publication - Ibrahim Chikowe
Pharmacy Department Kamuzu University of Health Sciences Blantyre Malawi
1 shared publication - Ibrahim Chikowe
Pharmacy Department, Kamuzu University of Health Sciences (KUHeS), Blantyre, Malawi
1 shared publication - Lesten Eliez Chisomo Chatepa
African Centre of Excellence in Neglected and Underutilised Biodiversity Mzuzu Malawi
1 shared publication
Latest Publications
- Open Access
- 16 October 2026
- Published by Elsevier in Cell Reports Physical Science
- Vol. 7 (11)
Concentration-dependent effects from the permeation enhancers capric acid and SNAC on peptide permeability
- 16 October 2026
- Published by Elsevier in Cell Reports Physical Science
- Vol. 7 (11)
Open AccessConcentration-dependent effects from the permeation enhancers capric acid and SNAC on peptide permeability
- Top Cited PapersOpen Access
- 22 January 2024
- Published by Springer Nature in Scientific Reports
- Vol. 14 (1) , 1-18
GC–MS analysis, molecular docking, and pharmacokinetic studies of Multidentia crassa extracts’ compounds for analgesic and anti-inflammatory activities in dentistry
Plant extracts have been useful for oral health or dentistry. However, only a few evidence-based justifications exist. This study evaluated Multidentia crassa (Hiern) Bridson & Verdc, one of the oral health-used plants in Malawi. Gas chromatography-mass spectrometry (GC-MS) and Fourier transform infrared (FT-IR) identified the extracts’ compounds. The pharmacokinetics of the identified compounds were studied using pkCSM and SwissADME, and molecular docking studies were used to identify potential drug candidates for oral health by predicting the binding affinity of the compounds to cyclooxygenases, interleukin-1 beta receptors, odontoblast cold sensor proteins, and purinergic receptor P2X3. FT-IR analysis showed characteristic peaks of phenols, carboxylic acids, alkenes, alkyl halides, amines, esters, ethers, aromatics, and lipids. GC–MS results showed the presence of 58 bioactive phytocompounds, some of which have various pharmacological activities relevant to oral health. Molecular docking further validated stigmastan-3,5-diene’s potency for analgesic and anti-inflammatory purposes. Based on a literature review, this is the first report on the bioactive compounds of M. crassa extracts showing analgesic and anti-inflammatory effects. This study's results can lead to new herbal and conventional medicines. Therefore, we recommend in vivo and in vitro studies to elucidate the pharmacological effects of the plant extracts.
- 22 January 2024
- Published by Springer Nature in Scientific Reports
- Vol. 14 (1) , 1-18
Top Cited PapersOpen AccessGC–MS analysis, molecular docking, and pharmacokinetic studies of Multidentia crassa extracts’ compounds for analgesic and anti-inflammatory activities in dentistry
Plant extracts have been useful for oral health or dentistry. However, only a few evidence-based justifications exist. This study evaluated Multidentia crassa (Hiern) Bridson & Verdc, one of the oral health-used plants in Malawi. Gas chromatography-mass spectrometry (GC-MS) and Fourier transform infrared (FT-IR) identified the extracts’ compounds. The pharmacokinetics of the identified compounds were studied using pkCSM and SwissADME, and molecular docking studies were used to identify potential drug candidates for oral health by predicting the binding affinity of the compounds to cyclooxygenases, interleukin-1 beta receptors, odontoblast cold sensor proteins, and purinergic receptor P2X3. FT-IR analysis showed characteristic peaks of phenols, carboxylic acids, alkenes, alkyl halides, amines, esters, ethers, aromatics, and lipids. GC–MS results showed the presence of 58 bioactive phytocompounds, some of which have various pharmacological activities relevant to oral health. Molecular docking further validated stigmastan-3,5-diene’s potency for analgesic and anti-inflammatory purposes. Based on a literature review, this is the first report on the bioactive compounds of M. crassa extracts showing analgesic and anti-inflammatory effects. This study's results can lead to new herbal and conventional medicines. Therefore, we recommend in vivo and in vitro studies to elucidate the pharmacological effects of the plant extracts.