Min Wang
Research Subjects
Min Wang has a total of 14 co-authors. Here are the top co-authors by number of shared publications:
- Chen Xin
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China
1 shared publication - Dongrui Zhang
Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology; National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering); School of Biological Science and Medical Engineering, Beihang University 1 , Beijing 100083
1 shared publication - Fangjun Shu
New Mexico State University
1 shared publication Haoran Su
Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University 1 , Beijing 100083, China
1 shared publication- Jing Zhang
Key Laboratory of Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Medical Engineering & Engineering Medicine Innovation Center, Hangzhou International Innovation Institute, School of Engineering Medicine, Beihang University, Beijing, 100191, China.
1 shared publication - Kexin Li
Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University; Beijing 100083, China
1 shared publication
Latest Publications
- Open Access
- 19 January 2024
- Published by AIP Publishing in Applied Physics Reviews
- Vol. 11 (1)
Microfluidic organ chip of fluid–solid dynamic curved interface
Dynamic curved interfaces are fundamental and ubiquitous structures in biological systems. However, replicating the structure and function associated with these interfaces for mechanobiology and drug screening is challenging. Here, we develop a dynamic curvature-enabled microfluidic organ chip of two fluid–solid dynamic curved interfaces. One interface effectively integrates adjustable biomechanics, and the other controls drug release with open microfluidics. The fluid–solid interface sensed by the cells can modulate the residual stress, stiffness, strain of the solid phase, and the flow shear stress of the fluid phase. Using the chip, we investigate the mechanotransductive responses of endothelial and epithelial cells, including Piezo1, Ca2+, and YAP, and reveal that the response of the endothelium to combined dynamic cyclic strain and flow shear stress is different from separate stimulation and also disparate from the epithelium. Furthermore, direct and high-efficiency drug release to cells is realized by constructing the other fluid–solid interface on the back side of cells, where drugs are encapsulated within cross-linked alginate hydrogel in the open microfluidic channel. Then, we replicate object-specific and location-specific biomechanical environments within carotid bifurcation and prove the effectiveness of drug delivery. Our design exemplifies dynamic curved biological interfaces with controlled mechanical environments and holds potential for patient-specific medicine.
- 19 January 2024
- Published by AIP Publishing in Applied Physics Reviews
- Vol. 11 (1)
Open AccessMicrofluidic organ chip of fluid–solid dynamic curved interface
Dynamic curved interfaces are fundamental and ubiquitous structures in biological systems. However, replicating the structure and function associated with these interfaces for mechanobiology and drug screening is challenging. Here, we develop a dynamic curvature-enabled microfluidic organ chip of two fluid–solid dynamic curved interfaces. One interface effectively integrates adjustable biomechanics, and the other controls drug release with open microfluidics. The fluid–solid interface sensed by the cells can modulate the residual stress, stiffness, strain of the solid phase, and the flow shear stress of the fluid phase. Using the chip, we investigate the mechanotransductive responses of endothelial and epithelial cells, including Piezo1, Ca2+, and YAP, and reveal that the response of the endothelium to combined dynamic cyclic strain and flow shear stress is different from separate stimulation and also disparate from the epithelium. Furthermore, direct and high-efficiency drug release to cells is realized by constructing the other fluid–solid interface on the back side of cells, where drugs are encapsulated within cross-linked alginate hydrogel in the open microfluidic channel. Then, we replicate object-specific and location-specific biomechanical environments within carotid bifurcation and prove the effectiveness of drug delivery. Our design exemplifies dynamic curved biological interfaces with controlled mechanical environments and holds potential for patient-specific medicine.