Aayush Arya
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Aayush Arya has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Alejandro Lozano
Department of Biomedical Data Science, Stanford University, Stanford, CA, USA
1 shared publication - Henderson James Cleaves
Department of Chemistry Howard University Washington DC USA
1 shared publication - Huan Chen
National High Magnetic Field Laboratory, Ion Cyclotron Resonance User Facility, Florida State University, 1800 East Paul Dirac Dr., Tallahassee, Florida 32310-4005, United States
1 shared publication - Jakob Lykke Andersen
Department of Mathematics and Computer Science University of Southern Denmark Odense Denmark
1 shared publication - Jessica Ray
Blue Marble Space Institute of Science, Seattle, 98104 WA, United States
1 shared publication - Romulo Cruz-Simbron
Department of Chemistry, University of Colorado Boulder, Cristol Chemistry, 215 UCB, Boulder, CO, USA
1 shared publication
Latest Publications
- Open Access
- 4 February 2024
- Published by American Chemical Society (ACS) in ChemRxiv
Combined Network and High Resolution Mass Spectrometry Analysis of the Formose Reaction Reveals Mechanisms for Emergent Behaviors
The formose reaction (FR) autocatalytically converts simple plausibly prebiotic feedstocks into molecules of biological interest, including ribose. Autocatalysis is a hallmark of life, thus various studies have explored the formose reaction with respect to the origins of life. The FR is robust under appropriate conditions, occurring readily at low temperatures from various substrates, and has been implicated in the generation of meteoritic organic compounds. We explored the FR here using a combination of in silico modeling techniques and high resolution mass spectrometry. The models match experimental results well, and point to the FR being much more complex than previously modeled or measured, and help explain the FR’s potential to generate homochirality and primitive compartments, both of which are also hallmarks of life, before the emergence of the complex directed molecular encoding suggested by the RNA World model. These results suggest the FR requires further study with regard to the origins of life, and its importance may lie in the way it enables and coordinates emergent chemistries, rather than the particular products it generates, such as ribose.
- 4 February 2024
- Published by American Chemical Society (ACS) in ChemRxiv
Open AccessCombined Network and High Resolution Mass Spectrometry Analysis of the Formose Reaction Reveals Mechanisms for Emergent Behaviors
The formose reaction (FR) autocatalytically converts simple plausibly prebiotic feedstocks into molecules of biological interest, including ribose. Autocatalysis is a hallmark of life, thus various studies have explored the formose reaction with respect to the origins of life. The FR is robust under appropriate conditions, occurring readily at low temperatures from various substrates, and has been implicated in the generation of meteoritic organic compounds. We explored the FR here using a combination of in silico modeling techniques and high resolution mass spectrometry. The models match experimental results well, and point to the FR being much more complex than previously modeled or measured, and help explain the FR’s potential to generate homochirality and primitive compartments, both of which are also hallmarks of life, before the emergence of the complex directed molecular encoding suggested by the RNA World model. These results suggest the FR requires further study with regard to the origins of life, and its importance may lie in the way it enables and coordinates emergent chemistries, rather than the particular products it generates, such as ribose.