Tess Z. Griffin
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Tess Z. Griffin has a total of 42 co-authors. Here are the top co-authors by number of shared publications:
- Michael V. Heinz
Center for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States; Department of Psychiatry, Geisel School of Medicine, Dartmouth College, Lebanon, NH, United States
12 shared publications - Nicholas C. Jacobson
Dartmouth College, Hanover, New Hampshire, USA
12 shared publications - Amanda C. Collins
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, United States; Department of Psychiatry, Harvard Medical School, Boston, MA, United States
10 shared publications - Damien Lekkas
Center for Behavioral Intervention Technologies, Northwestern University Feinberg School of Medicine Chicago Illinois USA
10 shared publications - Andrew T. Campbell
Center for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College
9 shared publications - Arvind Pillai
Department of Computer Science, Dartmouth College
9 shared publications
Latest Publications
- Open Access
- 22 May 2026
- Published by Center for Open Science in PsyArXiv
Reliability of Passive Sensing Data: A Multi-Method Evaluation in Depression
Passive data are increasingly used to capture continuous and unobtrusive information in psychological research. While digital markers based on step count, time at home, distance traveled, and sleep are frequently associated with depression-related and other psychological constructs, the reliability of passive data is rarely evaluated, potentially limiting credibility. In this paper, we evaluated the reliability of five depression-related constructs–sleep disturbance, activity level, affective dysregulation, behavioral inactivation, and social withdrawal– using three approaches: internal consistency, temporal stability, and inter-rater agreement. Analyses were conducted across daily, weekly, and monthly aggregation in 294 clinically depressed individuals over 90 days. Results revealed heterogeneity across constructs, measures, and timescales. Between-person internal consistency was generally high, indicating that passive measures can robustly differentiate individuals (mean consistency = .88, range = .32–1). Activity emerged as the most reliable construct, showing high between-person (mean = .92) and within-person (mean = .75) consistency, particularly at daily and weekly timescales. In contrast, constructs such as sleep, behavioral inactivation, and social withdrawal showed greater variability and often low within-person reliability, suggesting that their measures capture distinct constructs. Temporal stability increased with longer aggregation windows: while day-to-day behavior fluctuated considerably (mean intra class correlation (ICC) = .37), stability was moderate weekly (mean ICC = .64) and even higher monthly (mean ICC = .78). Lastly, device-specific differences highlight the need to account for measurement effects (Steps (Garmin vs phone): r = .52). These findings underscore a critical yet often overlooked aspect of passive sensing research: reliability should be systematically evaluated when constructing and interpreting passive measures.
- 22 May 2026
- Published by Center for Open Science in PsyArXiv
Open AccessReliability of Passive Sensing Data: A Multi-Method Evaluation in Depression
Passive data are increasingly used to capture continuous and unobtrusive information in psychological research. While digital markers based on step count, time at home, distance traveled, and sleep are frequently associated with depression-related and other psychological constructs, the reliability of passive data is rarely evaluated, potentially limiting credibility. In this paper, we evaluated the reliability of five depression-related constructs–sleep disturbance, activity level, affective dysregulation, behavioral inactivation, and social withdrawal– using three approaches: internal consistency, temporal stability, and inter-rater agreement. Analyses were conducted across daily, weekly, and monthly aggregation in 294 clinically depressed individuals over 90 days. Results revealed heterogeneity across constructs, measures, and timescales. Between-person internal consistency was generally high, indicating that passive measures can robustly differentiate individuals (mean consistency = .88, range = .32–1). Activity emerged as the most reliable construct, showing high between-person (mean = .92) and within-person (mean = .75) consistency, particularly at daily and weekly timescales. In contrast, constructs such as sleep, behavioral inactivation, and social withdrawal showed greater variability and often low within-person reliability, suggesting that their measures capture distinct constructs. Temporal stability increased with longer aggregation windows: while day-to-day behavior fluctuated considerably (mean intra class correlation (ICC) = .37), stability was moderate weekly (mean ICC = .64) and even higher monthly (mean ICC = .78). Lastly, device-specific differences highlight the need to account for measurement effects (Steps (Garmin vs phone): r = .52). These findings underscore a critical yet often overlooked aspect of passive sensing research: reliability should be systematically evaluated when constructing and interpreting passive measures.
- Top Cited Papers
- 1 March 2026
- Published by American Psychological Association (APA) in Psychological Assessment
- Vol. 38 (3) , 159-170
Psychometric properties and validity of a Mobile Patient Health Questionnaire–9 (MPHQ-9) for ecological momentary assessment in depressed adults.
Ecological momentary assessment is well-suited for capturing rapid symptom dynamics, and it is increasingly used to measure depression symptoms. However, few depression measures are validated for ecological momentary assessment use in the manner expected for traditional questionnaires. Therefore, this study examined the internal consistency, longitudinal stability, and convergent validity of the Mobile Patient Health Questionnaire-9 (MPHQ-9), a version of the Patient Health Questionnaire-9 (PHQ-9) modified for ecological momentary assessment. Depressed participants (N = 280; female = 83.93%; White = 79.29%) completed the MPHQ-9 three times daily for 90 days. Data from the first and last 2 weeks were analyzed to align with a prestudy PHQ-9 and poststudy PHQ-9 and Inventory of Depression and Anxiety Symptoms-II. The MPHQ-9 demonstrated fair to substantial adjusted item-total correlations (r = .42-.83), often exceeding the PHQ-9 (r = .39-.72), with Cronbach's α coefficients of .91 and .81, respectively. Reliability analyses of the MPHQ-9 using generalizability theory and multilevel modeling to account for repeated measures yielded substantial between-person reliability (∼1.0) but mixed within-person reliability estimates of .81 (generalizability theory) and .44 (multilevel modeling). The MPHQ-9 showed moderate stability (r = .69, intraclass correlation coefficient = .58), compared to the slight stability of the PHQ-9 (r = .39, intraclass correlation coefficient = .37). There was moderate agreement between the MPHQ-9 and both the PHQ-9 (r = .71) and the Inventory of Depression and Anxiety Symptoms-II General Depression subscale (r = .65). Supplementary analyses identified short forms with similar convergent validity but reduced symptom-level information. This study provides initial validation of the MPHQ-9 and compares its psychometric properties to the traditional PHQ-9. (PsycInfo Database Record (c) 2026 APA, all rights reserved).
- 1 March 2026
- Published by American Psychological Association (APA) in Psychological Assessment
- Vol. 38 (3) , 159-170
Top Cited PapersPsychometric properties and validity of a Mobile Patient Health Questionnaire–9 (MPHQ-9) for ecological momentary assessment in depressed adults.
Ecological momentary assessment is well-suited for capturing rapid symptom dynamics, and it is increasingly used to measure depression symptoms. However, few depression measures are validated for ecological momentary assessment use in the manner expected for traditional questionnaires. Therefore, this study examined the internal consistency, longitudinal stability, and convergent validity of the Mobile Patient Health Questionnaire-9 (MPHQ-9), a version of the Patient Health Questionnaire-9 (PHQ-9) modified for ecological momentary assessment. Depressed participants (N = 280; female = 83.93%; White = 79.29%) completed the MPHQ-9 three times daily for 90 days. Data from the first and last 2 weeks were analyzed to align with a prestudy PHQ-9 and poststudy PHQ-9 and Inventory of Depression and Anxiety Symptoms-II. The MPHQ-9 demonstrated fair to substantial adjusted item-total correlations (r = .42-.83), often exceeding the PHQ-9 (r = .39-.72), with Cronbach's α coefficients of .91 and .81, respectively. Reliability analyses of the MPHQ-9 using generalizability theory and multilevel modeling to account for repeated measures yielded substantial between-person reliability (∼1.0) but mixed within-person reliability estimates of .81 (generalizability theory) and .44 (multilevel modeling). The MPHQ-9 showed moderate stability (r = .69, intraclass correlation coefficient = .58), compared to the slight stability of the PHQ-9 (r = .39, intraclass correlation coefficient = .37). There was moderate agreement between the MPHQ-9 and both the PHQ-9 (r = .71) and the Inventory of Depression and Anxiety Symptoms-II General Depression subscale (r = .65). Supplementary analyses identified short forms with similar convergent validity but reduced symptom-level information. This study provides initial validation of the MPHQ-9 and compares its psychometric properties to the traditional PHQ-9. (PsycInfo Database Record (c) 2026 APA, all rights reserved).
- Open Access
- 14 February 2026
- Published by Elsevier in Behaviour Research and Therapy
- Vol. 199, 104986
Interindividual differences in digital phenotypes of major depressive disorder: A passive sensing study using smartphone and wearable sensor data
- 14 February 2026
- Published by Elsevier in Behaviour Research and Therapy
- Vol. 199, 104986
Open AccessInterindividual differences in digital phenotypes of major depressive disorder: A passive sensing study using smartphone and wearable sensor data
- 28 August 2025
- Published by Massachusetts Medical Society in NEJM AI
- Vol. 2 (9)
Response to Letters about “Randomized Trial of a Generative AI Chatbot for Mental Health Treatment”
- 28 August 2025
- Published by Massachusetts Medical Society in NEJM AI
- Vol. 2 (9)
Response to Letters about “Randomized Trial of a Generative AI Chatbot for Mental Health Treatment”
- Open Access
- 1 July 2025
- Published by Springer Nature in BMC Psychiatry
- Vol. 25 (1) , 1-16
Acute suicidal ideation in context: highlighting sentiment-based markers through the diary entries of a clinically depressed sample
Despite major strides in conceptualizing and modeling the multifaceted nature of suicidal thought and behavior (STB) over the past few decades, the overall predictability of STB has not improved. This may be partly due to the dynamic nature of suicidal ideation (SI), which often fluctuates over hours, yet is largely overlooked in studies. Bolstered by the application and promise of natural language processing (NLP) across the mental health field, efforts toward richer operationalization of acute SI may include analyses on written data that occur alongside changes in SI, thus offering a better understanding of STB as it unfolds. Ecological momentary assessment (EMA) data from 268 participants with major depressive disorder (MDD) were utilized to investigate acute changes in SI. Data consisted of thrice-daily SI severity scores measured through self-report responses to item 9 of the Patient Health Questionnaire mobile version (MPHQ-9) as well as free-form diary text. Using difference scores and probability of acute change thresholds, eleven acute SI phase trajectory types were defined to label change in SI over three consecutive EMAs. In total, 5,938 acute SI trajectories were paired with the temporally centered diary entries. The Sentiment Analysis and Cognition Engine (SEANCE) tool was applied to quantify the written content of each diary entry across eight established lexica. Entry results were grouped based on phase trajectory type, and the Kruskal-Wallis test was employed with post-hoc multiple hypothesis correction to statistically compare SEANCE features between all group pairs. There were 131 statistically significant (adjusted p-value < 0.05) pairwise differences between acute SI phase trajectory groups, implicating 31 NLP features. Consistent with the literature, results highlighted qualities of writing that are generally associated with heightened SI, including personal pronoun usage, passivity, and negative valence. Patterns of significance also uncovered novel contextual nuance in terms of how characteristics such as verbosity, hostility, anger, and pleasantness present in relation to SI over short change trajectories. This work provides an accessible exploratory framework that capitalizes on the benefits of dense EMA sampling and NLP to profile and quantify acute SI trajectories. The use of the MPHQ’s item 9 to quantify SI is an important limitation as it is designed to also capture precursory SI, passive SI, and SI-adjacent behaviors, potentially overestimating the SI expressed by participants. Nonetheless, future research should continue to focus on short timeframes as there are likely important signals and interpretative nuances to SI expression that have yet to be fully detailed.
- 1 July 2025
- Published by Springer Nature in BMC Psychiatry
- Vol. 25 (1) , 1-16
Open AccessAcute suicidal ideation in context: highlighting sentiment-based markers through the diary entries of a clinically depressed sample
Despite major strides in conceptualizing and modeling the multifaceted nature of suicidal thought and behavior (STB) over the past few decades, the overall predictability of STB has not improved. This may be partly due to the dynamic nature of suicidal ideation (SI), which often fluctuates over hours, yet is largely overlooked in studies. Bolstered by the application and promise of natural language processing (NLP) across the mental health field, efforts toward richer operationalization of acute SI may include analyses on written data that occur alongside changes in SI, thus offering a better understanding of STB as it unfolds. Ecological momentary assessment (EMA) data from 268 participants with major depressive disorder (MDD) were utilized to investigate acute changes in SI. Data consisted of thrice-daily SI severity scores measured through self-report responses to item 9 of the Patient Health Questionnaire mobile version (MPHQ-9) as well as free-form diary text. Using difference scores and probability of acute change thresholds, eleven acute SI phase trajectory types were defined to label change in SI over three consecutive EMAs. In total, 5,938 acute SI trajectories were paired with the temporally centered diary entries. The Sentiment Analysis and Cognition Engine (SEANCE) tool was applied to quantify the written content of each diary entry across eight established lexica. Entry results were grouped based on phase trajectory type, and the Kruskal-Wallis test was employed with post-hoc multiple hypothesis correction to statistically compare SEANCE features between all group pairs. There were 131 statistically significant (adjusted p-value < 0.05) pairwise differences between acute SI phase trajectory groups, implicating 31 NLP features. Consistent with the literature, results highlighted qualities of writing that are generally associated with heightened SI, including personal pronoun usage, passivity, and negative valence. Patterns of significance also uncovered novel contextual nuance in terms of how characteristics such as verbosity, hostility, anger, and pleasantness present in relation to SI over short change trajectories. This work provides an accessible exploratory framework that capitalizes on the benefits of dense EMA sampling and NLP to profile and quantify acute SI trajectories. The use of the MPHQ’s item 9 to quantify SI is an important limitation as it is designed to also capture precursory SI, passive SI, and SI-adjacent behaviors, potentially overestimating the SI expressed by participants. Nonetheless, future research should continue to focus on short timeframes as there are likely important signals and interpretative nuances to SI expression that have yet to be fully detailed.
- 1 July 2025
- Published by American Psychological Association (APA) in Journal of Psychopathology and Clinical Science
- Vol. 134 (5) , 488-502
Semantic signals in self-reference: The detection and prediction of depressive symptoms from the daily diary entries of a sample with major depressive disorder.
Individuals with major depressive disorder (MDD) experience fewer positive and more negative emotions and use fewer positive words to describe themselves. Natural language processing techniques have been used to predict depression, with pronoun and emotion usage being identified as important features. However, it is unclear how depressed individuals use positive and negative words when writing about themselves. Individuals with MDD (N = 258) completed ecological momentary assessments three times a day (including the Patient Health Questionnaire-9 [PHQ-9] and a free-text diary entry) and weekly ecological momentary assessments (including a free-text response to a life events prompt) over a 90-day study period. Using natural language processing techniques, we generated 20 model features to detect and predict averages of and changes in weekly depression from diary entries. Four regression models detected and predicted total PHQ-9 and changes in PHQ-9, and two classification models detected and predicted moderate to severe depression. The models classified current (area under the receiver operating curve [AUC] = 0.68) and future depression (AUC = 0.63), and suggest that lower valence increased usage of "I"/"me"/"my," and lower valence of passages with "I"/"me" as the subject, influenced model predictions toward more severe depression, supporting prior research. These findings highlight that depressed individuals use less positive and more negative words when referring to themselves. Treatments targeting positive affect and digital interventions with written components may be beneficial for targeting MDD. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
- 1 July 2025
- Published by American Psychological Association (APA) in Journal of Psychopathology and Clinical Science
- Vol. 134 (5) , 488-502
Semantic signals in self-reference: The detection and prediction of depressive symptoms from the daily diary entries of a sample with major depressive disorder.
Individuals with major depressive disorder (MDD) experience fewer positive and more negative emotions and use fewer positive words to describe themselves. Natural language processing techniques have been used to predict depression, with pronoun and emotion usage being identified as important features. However, it is unclear how depressed individuals use positive and negative words when writing about themselves. Individuals with MDD (N = 258) completed ecological momentary assessments three times a day (including the Patient Health Questionnaire-9 [PHQ-9] and a free-text diary entry) and weekly ecological momentary assessments (including a free-text response to a life events prompt) over a 90-day study period. Using natural language processing techniques, we generated 20 model features to detect and predict averages of and changes in weekly depression from diary entries. Four regression models detected and predicted total PHQ-9 and changes in PHQ-9, and two classification models detected and predicted moderate to severe depression. The models classified current (area under the receiver operating curve [AUC] = 0.68) and future depression (AUC = 0.63), and suggest that lower valence increased usage of "I"/"me"/"my," and lower valence of passages with "I"/"me" as the subject, influenced model predictions toward more severe depression, supporting prior research. These findings highlight that depressed individuals use less positive and more negative words when referring to themselves. Treatments targeting positive affect and digital interventions with written components may be beneficial for targeting MDD. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
- Top Cited Papers
- 27 March 2025
- Published by Massachusetts Medical Society in NEJM AI
- Vol. 2 (4)
Randomized Trial of a Generative AI Chatbot for Mental Health Treatment
- 27 March 2025
- Published by Massachusetts Medical Society in NEJM AI
- Vol. 2 (4)
Top Cited PapersRandomized Trial of a Generative AI Chatbot for Mental Health Treatment
- 25 November 2024
- Published by Elsevier in Journal of Affective Disorders
- Vol. 372, 27-36
Anhedonia in flux: Understanding the associations of emotion regulation and anxiety with anhedonia dynamics in a sample with major depressive disorder
- 25 November 2024
- Published by Elsevier in Journal of Affective Disorders
- Vol. 372, 27-36
Anhedonia in flux: Understanding the associations of emotion regulation and anxiety with anhedonia dynamics in a sample with major depressive disorder
- 27 July 2024
- Published by Elsevier in Psychiatry Research
- Vol. 339, 116110
From mood to use: Using ecological momentary assessments to examine how anhedonia and depressed mood impact cannabis use in a depressed sample
- 27 July 2024
- Published by Elsevier in Psychiatry Research
- Vol. 339, 116110
From mood to use: Using ecological momentary assessments to examine how anhedonia and depressed mood impact cannabis use in a depressed sample