Szu-An Chen
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Szu-An Chen has a total of 3 co-authors. Here are the top co-authors by number of shared publications:
- Pin-Han Chen
Department of Resources Engineering, National Cheng Kung University, Tainan City 701401, Taiwan
1 shared publication - Wei-Chung Chen
Department of Resources Engineering, National Cheng Kung University, Tainan City 701401, Taiwan
1 shared publication - Wei-Sheng Chen
Department of Resources Engineering, National Cheng Kung University, Tainan 701401, Taiwan
1 shared publication
Latest Publications
- Open Access
- 6 February 2024
- Published by MDPI AG in Applied Sciences
- Vol. 14 (4) , 1336
Synthesis of High-Precision Sub-Micron CaCO3 Anticancer Drug Carriers from Coral Remains
Calcium carbonate (CaCO3) particles have attracted increasing attention as a promising material for drug delivery systems. In this study, coral remains were utilized as a raw material for a novel drug carrier. A series of pre-treatment and parameter experiments were conducted to synthesize sub-micron spherical CaCO3 particles. The CaCO3 particles exhibited uniform size distribution, with the minimum mean size being only 344 nm. The effects on the CaCO3 crystal phases and particle sizes were also discussed in this study. Drug loading experiments were also conducted to assess the feasibility of the CaCO3 drug carrier. We loaded TRITC-Dextran into CaCO3 particles for the simulation experiments. The loading capacity reached up to 9.6 wt.%, which was as high as common drug carriers such as liposomes. In this study, we aimed not only to tackle the local environmental issues caused by coral remains, but also to synthesize a suitable drug carrier for cancer therapy using the outstanding properties and low cost of CaCO3.
- 6 February 2024
- Published by MDPI AG in Applied Sciences
- Vol. 14 (4) , 1336
Open AccessSynthesis of High-Precision Sub-Micron CaCO3 Anticancer Drug Carriers from Coral Remains
Calcium carbonate (CaCO3) particles have attracted increasing attention as a promising material for drug delivery systems. In this study, coral remains were utilized as a raw material for a novel drug carrier. A series of pre-treatment and parameter experiments were conducted to synthesize sub-micron spherical CaCO3 particles. The CaCO3 particles exhibited uniform size distribution, with the minimum mean size being only 344 nm. The effects on the CaCO3 crystal phases and particle sizes were also discussed in this study. Drug loading experiments were also conducted to assess the feasibility of the CaCO3 drug carrier. We loaded TRITC-Dextran into CaCO3 particles for the simulation experiments. The loading capacity reached up to 9.6 wt.%, which was as high as common drug carriers such as liposomes. In this study, we aimed not only to tackle the local environmental issues caused by coral remains, but also to synthesize a suitable drug carrier for cancer therapy using the outstanding properties and low cost of CaCO3.