Sijia Chen
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Sijia Chen has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Andrea Britta Maier
NUS Academy for Healthy Longevity, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore, Singapore
1 shared publication - Ann Clementina Theodora Maria Vossen
Leiden University Medical Center, LUCID Medical Microbiology & Infection Control
1 shared publication - Anton J. M. de Craen
Department of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, the Netherlands
1 shared publication - Evelyna Derhovanessian
Department of Internal Medicine II, Centre for Medical Research, University of Tübingen, Tübingen, Germany
1 shared publication - Graham Pawelec
Institute of Immunology, University of Tübingen, 72076 Tübingen, Germany
1 shared publication - Rudi G. J. Westendorp
Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
1 shared publication
Latest Publications
- Open Access
- 28 August 2012
- Published by Springer Nature in Immunity & Ageing
- Vol. 9 (1) , 18
Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
Background: Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old.Results: CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05).Conclusions: In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly.
- 28 August 2012
- Published by Springer Nature in Immunity & Ageing
- Vol. 9 (1) , 18
Open AccessCytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study
Background: Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old.Results: CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05).Conclusions: In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly.