Valeria Rahamim
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Valeria Rahamim has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Aharon Azagury
The Department of Chemical Engineering and Biotechnology, Ariel University, Ariel-407000, Israel
1 shared publication - Chen Damti
Department of Chemical Sciences, Faculty of Natural Sciences, Ariel University, Ariel 40700, Israel
1 shared publication - Dhaval Patel
Institute of Personal Medicine, Ariel University, Ariel 40700, P.O.B. 3, Israel
1 shared publication - Eliyahu Drori
Department of Chemical Engineering, Ariel University, Kiryat Hamada 3, Ariel 4070000, Israel
1 shared publication - Roni Avital
Department of Chemical Engineering, Ariel University, Kiryat Hamada 3, Ariel 4070000, Israel
1 shared publication - Sarah Coopersmith
Department of Chemical Engineering, Ariel University, Kiryat Hamada 3, Ariel 4070000, Israel
1 shared publication
Latest Publications
- Open Access
- 21 February 2024
- Published by MDPI AG in Marine Drugs
- Vol. 22 (3) , 98
Algae-Based Nanoparticles for Oral Drug Delivery Systems
Drug administration by oral delivery is the preferred route, regardless of some remaining challenges, such as short resident time and toxicity issues. One strategy to overcome these barriers is utilizing mucoadhesive vectors that can increase intestinal resident time and systemic uptake. In this study, biomimetic nanoparticles (NPs) were produced from 14 types of edible algae and evaluated for usage as oral DDSs by measuring their size, surface charge, morphology, encapsulation efficiency, mucoadhesion force, and cellular uptake into Caco-2 cells. The NPs composed of algal materials (aNPs) exhibited a spherical morphology with a size range of 126–606 nm and a surface charge of −9 to −38 mV. The mucoadhesive forces tested ex vivo against mice, pigs, and sheep intestines revealed significant variation between algae and animal models. Notably, Arthospira platensis (i.e., Spirulina) NPs (126 ± 2 nm, −38 ± 3 mV) consistently exhibited the highest mucoadhesive forces (up to 3127 ± 272 µN/mm²). Moreover, a correlation was found between high mucoadhesive force and high cellular uptake into Caco-2 cells, further supporting the potential of aNPs by indicating their ability to facilitate drug absorption into the human intestinal epithelium. The results presented herein serve as a proof of concept for the possibility of aNPs as oral drug delivery vehicles.
- 21 February 2024
- Published by MDPI AG in Marine Drugs
- Vol. 22 (3) , 98
Open AccessAlgae-Based Nanoparticles for Oral Drug Delivery Systems
Drug administration by oral delivery is the preferred route, regardless of some remaining challenges, such as short resident time and toxicity issues. One strategy to overcome these barriers is utilizing mucoadhesive vectors that can increase intestinal resident time and systemic uptake. In this study, biomimetic nanoparticles (NPs) were produced from 14 types of edible algae and evaluated for usage as oral DDSs by measuring their size, surface charge, morphology, encapsulation efficiency, mucoadhesion force, and cellular uptake into Caco-2 cells. The NPs composed of algal materials (aNPs) exhibited a spherical morphology with a size range of 126–606 nm and a surface charge of −9 to −38 mV. The mucoadhesive forces tested ex vivo against mice, pigs, and sheep intestines revealed significant variation between algae and animal models. Notably, Arthospira platensis (i.e., Spirulina) NPs (126 ± 2 nm, −38 ± 3 mV) consistently exhibited the highest mucoadhesive forces (up to 3127 ± 272 µN/mm²). Moreover, a correlation was found between high mucoadhesive force and high cellular uptake into Caco-2 cells, further supporting the potential of aNPs by indicating their ability to facilitate drug absorption into the human intestinal epithelium. The results presented herein serve as a proof of concept for the possibility of aNPs as oral drug delivery vehicles.