Shaikh Yahya

In-vitro dissolution study is crucial for quality assurance and stability, serving as a surrogate test for evaluating in-vivo performance of a drug. The dissolution procedure should be designed using an appropriate validated approach, depending on the type of dosage form. Dissolution testing is crucial to regulatory decision-making in a number of aspects. Conventional formulations have validated regulatory-compliant dissolution methods, conversely novel drug formulations like nanoparticles and microparticles lack standard validated procedures for the same. The present article provides information about the various compendial and non-compendial methods available for in-vitro dissolution testing of nano-formulations including the selection of dissolution media, different factors affecting the release, advancements in the dissolution procedures and also included the recently developed marketed nano-formulations.

Hepatocellular carcinoma (HCC) is the seventh most common cancer and the third leading cause of cancer-related death globally. It has a poor prognosis and is resistant to the majority of chemotherapeutics. The present review aimed to highlight studies into the tumor cycle and its prevention by appropriate herbal (Ayurvedic/Unani) medicine that is essential to reduce the effects of the deadly disease. There are few treatment options for end stage liver cancer, which forces patients to undergo expensive liver transplantation, which is not an option in the majority of nations. Herbal medicine has experienced exponential growth in recent years, and due to its natural origins and limited side effects, these medications are becoming more and more popular in both developed and developing nations. The anti diabetic function of S. cumini has the most potential nutraceutical value among these advantageous physiological effects. The numerous phytoconstituents included in the fruit, including tannins, alkaloids, steroids, flavonoids, terpenoids, fatty acids, phenols, minerals, carbohydrates, and vitamins, are primarily responsible for S. cumini's favourable benefits on health. An overview of the scientific data supporting S. cumini's pharmacological potential is provided in this review.