Giovanni Nisato

The conect4children (c4c) initiative was established to facilitate the development of new drugs and other therapies for paediatric patients. It is widely recognised that there are not enough medicines tested for all relevant ages of the paediatric population. To overcome this, it is imperative that clinical data from different sources are interoperable and can be pooled for larger post hoc studies. c4c has collaborated with the Clinical Data Interchange Standards Consortium (CDISC) to develop cross-cutting data resources that build on existing CDISC standards in an effort to standardise paediatric data. The natural next step was an extension to disease-specific data items. c4c brought together several existing initiatives and resources relevant to disease-specific data and analysed their use for standardising disease-specific data in clinical trials. Several case studies that combined disease-specific data from multiple trials have demonstrated the need for disease-specific data standardisation. We identified three relevant initiatives. These include European Reference Networks, European Joint Programme on Rare Diseases, and Pistoia Alliance. Other resources reviewed were National Cancer Institute Enterprise Vocabulary Services, CDISC standards, pharmaceutical company-specific data dictionaries, Human Phenotype Ontology, Phenopackets, Unified Registry for Inherited Metabolic Disorders, Orphacodes, Rare Disease Cures Accelerator-Data and Analytics Platform (RDCA-DAP), and Observational Medical Outcomes Partnership. The collaborative partners associated with these resources were also reviewed briefly. A plan of action focussed on collaboration was generated for standardising disease-specific paediatric clinical trial data. A paediatric data standards multistakeholder and multi-project user group was established to guide the remaining actions—FAIRification of metadata, a Phenopackets pilot with RDCA-DAP, applying Orphacodes to case report forms of clinical trials, introducing CDISC standards into European Reference Networks, testing of the CDISC Pediatric User Guide using data from the mentioned resources and organisation of further workshops and educational materials.

The identification and application of biomarkers in the clinical and medical fields has an enormous impact on society. The increase of digital devices and the rise in popularity of health-related mobile apps has produced a new trove of biomarkers in large, diverse, and complex data. However, the unclear definition of digital biomarkers, population groups, and their intersection with traditional biomarkers hinders their discovery and validation. We have identified current issues in the field of digital biomarkers and put forth suggestions to address them during the DayOne Workshop with participants from academia and industry. We have found similarities and differences between traditional and digital biomarkers in order to synchronize semantics, define unique features, review current regulatory procedures, and describe novel applications that enable precision medicine.

Solution processable organic tandem solar cells offer a promising approach to achieve cost-effective, lightweight and flexible photovoltaics. In order to further enhance the efficiency of optimized organic tandem cells, diffractive light-management nanostructures were designed for an optimal redistribution of the light as function of both wavelength and propagation angles in both sub-cells. As the fabrication of these optical structures is compatible with roll-to-roll production techniques such as hot-embossing or UV NIL imprinting, they present an optimal cost-effective solution for printed photovoltaics. Tandem cells with power conversion efficiencies of 8-10% were fabricated in the ambient atmosphere by doctor blade coating, selected to approximate the conditions during roll-to-roll manufacturing. Application of the light management structure onto an 8.7% efficient encapsulated tandem cell boosted the conversion efficiency of the cell to 9.5%.

In this paper, a woven textile containing temperature and humidity sensors realized on flexible, plastic stripes is presented. The authors introduce two different sensors fabrication techniques: the first one consists of a conventional photolithography patterning technique; the second one, namely inkjet-printing, is here presented as an effective, low-cost alternative. In both cases, we obtain temperature and humidity sensors that can be easily integrated within a fabric by using a conventional weaving machine. All the sensors are fully characterized and the performances obtained with the two different fabrication techniques are compared and discussed, pointing out advantages and drawbacks resulting from each fabrication technique. The bending tests performed on these sensors show that they can be successfully woven without being damaged. A demonstrator, consisting of a mechanical support for the e-textile, a read-out electronic circuit, and a graphical PC interface to monitor the acquisition of humidity and temperature values, is also presented and described. This paper opens an avenue for real integration between printed electronics and traditional textile technology and materials. Printing techniques may be successfully used for the fabrication of e-textile devices, paving the way for the production of large area polymeric stripes and thus enabling new applications that, at the moment, cannot be developed with the standard lithography methods.

A flexible version is shown of a state of the art passive matrix LCD; a full colour STN display. By using polymer substrates, “ultra‐thin” optical layers (like retarders, colour filters and polarisers) and a flexible backlight a fully flexible CSTN demonstrator is obtained, that can be bend to a radius of 40 mm during operation.