Xiaofan Zhang

Deep learning has achieved remarkable success in image recognition, yet their inherent opacity poses challenges for deployment in critical domains. Concept-based interpretations aim to address this by explaining model reasoning through human-understandable concepts. However, existing post-hoc methods and ante-hoc concept bottleneck models (CBMs), suffer from limitations such as unreliable concept relevance, non-visual or labor-intensive concept definitions, and model or data-agnostic assumptions. This paper introduces Post-hoc Concept Bottleneck Model via Representation Decomposition (PCBM-ReD), a novel pipeline that retrofits interpretability onto pretrained opaque models. PCBM-ReD automatically extracts visual concepts from a pre-trained encoder, employs multimodal large language models (MLLMs) to label and filter concepts based on visual identifiability and task relevance, and selects an independent subset via reconstruction-guided optimization. Leveraging CLIP's visual-text alignment, it decomposes image representations into linear combination of concept embeddings to fit into the CBMs abstraction. Extensive experiments across 11 image classification tasks show PCBM-ReD achieves state-of-the-art accuracy, narrows the performance gap with end-to-end models, and exhibits better interpretability.

Recent pathological foundation models have substantially advanced visual representation learning and multimodal interaction. However, most models still rely on a static inference paradigm in which whole-slide images are processed once to produce predictions, without reassessment or targeted evidence acquisition under ambiguous diagnoses. This contrasts with clinical diagnostic workflows that refine hypotheses through repeated slide observations and further examination requests. We propose PathFound, an agentic multimodal model designed to support evidence-seeking inference in pathological diagnosis. PathFound integrates the power of pathological visual foundation models, vision-language models, and reasoning models trained with reinforcement learning to perform proactive information acquisition and diagnosis refinement by progressing through the initial diagnosis, evidence-seeking, and final decision stages. Across several large multimodal models, adopting this strategy consistently improves diagnostic accuracy, indicating the effectiveness of evidence-seeking workflows in computational pathology. Among these models, PathFound achieves state-of-the-art diagnostic performance across diverse clinical scenarios and demonstrates strong potential to discover subtle details, such as nuclear features and local invasions.

The complexity and variability of high-resolution pathological images present significant challenges in computational pathology. While AI-driven pathology foundation models have advanced the field, they require large-scale datasets, substantial storage, and significant computational resources, as well as rigorous validation for clinical applicability. We present PathOrchestra, a versatile pathology foundation model trained on 287,424 slides from 21 tissue types across three centers. Evaluated on 112 tasks from 61 private and 51 public datasets, covering digital slide preprocessing, pan-cancer classification, lesion identification, multi-cancer subtype classification, biomarker assessment, gene expression prediction, and structured report generation. Across 27,755 whole slide images and 9,415,729 region-of-interest images, it achieved over 0.950 accuracy in 47 tasks, including pan-cancer classification, lymphoma subtyping, and bladder cancer screening. It is the first to generate structured reports for colorectal cancer and lymphoma. Overall, PathOrchestra demonstrates the clinical readiness of large-scale self-supervised pathology foundation models, achieving high accuracy and offering potential to digital medicine integration.

Oral and maxillofacial radiology plays a vital role in dental healthcare, but radiographic image interpretation is limited by a shortage of trained professionals. While AI approaches have shown promise, existing dental AI systems are restricted by their single-modality focus, task-specific design, and reliance on costly labeled data, hindering their generalization across diverse clinical scenarios. To address these challenges, we introduce DentVFM, the first family of vision foundation models (VFMs) designed for dentistry. DentVFM generates task-agnostic visual representations for a wide range of dental applications and uses self-supervised learning on DentVista, a large curated dental imaging dataset with approximately 1.6 million multi-modal radiographic images from various medical centers. DentVFM includes 2D and 3D variants based on the Vision Transformer (ViT) architecture. To address gaps in dental intelligence assessment and benchmarks, we introduce DentBench, a comprehensive benchmark covering eight dental subspecialties, more diseases, imaging modalities, and a wide geographical distribution. DentVFM shows impressive generalist intelligence, demonstrating robust generalization to diverse dental tasks, such as disease diagnosis, treatment analysis, biomarker identification, and anatomical landmark detection and segmentation. Experimental results indicate DentVFM significantly outperforms supervised, self-supervised, and weakly supervised baselines, offering superior generalization, label efficiency, and scalability. Additionally, DentVFM enables cross-modality diagnostics, providing more reliable results than experienced dentists in situations where conventional imaging is unavailable. DentVFM sets a new paradigm for dental AI, offering a scalable, adaptable, and label-efficient model to improve intelligent dental healthcare and address critical gaps in global oral healthcare.

Automated CT report generation plays a crucial role in improving diagnostic accuracy and clinical workflow efficiency. However, existing methods lack interpretability and impede patient-clinician understanding, while their static nature restricts radiologists from dynamically adjusting assessments during image review. Inspired by interactive segmentation techniques, we propose a novel interactive framework for 3D lesion morphology reporting that seamlessly generates segmentation masks with comprehensive attribute descriptions, enabling clinicians to generate detailed lesion profiles for enhanced diagnostic assessment. To our best knowledge, we are the first to integrate the interactive segmentation and structured reports in 3D CT medical images. Experimental results across 15 lesion types demonstrate the effectiveness of our approach in providing a more comprehensive and reliable reporting system for lesion segmentation and capturing. The source code will be made publicly available following paper acceptance.