Cornelia H. Quaak
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Cornelia H. Quaak has a total of 14 co-authors. Here are the top co-authors by number of shared publications:
- Alexander H Jan Danser
Division of Vascular Medicine and Pharmacology, Department of Internal Medicine Erasmus University Medical Center Rotterdam the Netherlands
1 shared publication - Anna C. M. Kluivers
Department of Obstetrics and Gynaecology, Division of Obstetrics and Fetal Medicine Erasmus MC University Medical Center Rotterdam Rotterdam the Netherlands
1 shared publication Anneke J van Steensel-Boon
Department of Rheumatology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands
1 shared publicationAnnemarie G M G J Mulders
Department of Gynecology and Obstetrics, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands
1 shared publicationEsther Röder
Department of Rheumatology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands
1 shared publicationHetty M Wintjes
Department of Rheumatology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands
1 shared publication
Latest Publications
- Open Access
- 2 April 2024
- Published by Wolters Kluwer Health in Journal of the American Heart Association
- Vol. 13 (7) , e032655
Tumor Necrosis Factor Inhibitor Use Increases Birthweight in Pregnant Women With Rheumatoid Arthritis Independently of the Soluble Fms‐Like Tyrosine Kinase‐1/Placental Growth Factor Ratio
Background: To study whether the use of TNF (tumor necrosis factor) inhibitors (TNFi) by pregnant women with rheumatoid arthritis affects sFlt‐1 (soluble Fms‐like tyrosine kinase‐1), PlGF (placental growth factor), or their impact on birthweight. Methods and Results: sFlt‐1 and PlGF were measured in all trimesters of pregnancy in the Preconception Counseling in Active Rheumatoid Arthritis study and were compared according to the use of TNFi. The association of sFlt‐1 and PlGF with birthweight in relation to TNFi was determined. The study included 158 women, of whom 52.5% used TNFi during pregnancy. Both sFlt‐1 and PlGF increased during pregnancy, whereas their ratio declined. Taking into consideration the trimester‐related variation in levels of sFlt‐1 and PlGF, after correction for relevant confounders, the sFlt‐1/PlGF ratio was not significantly different between patients who did or did not use TNFi (sFlt‐1/PlGF ratio in the second trimester compared with the first trimester: estimated change 8.17 [95% CI, 2.54–26.29], P =0.79; sFlt‐1/PlGF ratio in the third trimester compared with the first trimester: estimated change 6.25 [95% CI, 1.73–22.50], P =0.25). In women who did not use TNFi, birthweight was significantly lower (3180 versus 3302 g; P =0.03), and sFlt‐1 displayed a negative correlation with birthweight ( r =−0.462, P r =−0.332, P =0.008). In TNFi users, these correlations were absent. Conclusions: TNF inhibitor use increases birthweight in pregnant women with rheumatoid arthritis independently of the sFlt‐1/PlGF ratio. Registration: http://clinicaltrials.gov . Unique identifier: NCT01345071.
- 2 April 2024
- Published by Wolters Kluwer Health in Journal of the American Heart Association
- Vol. 13 (7) , e032655
Open AccessTumor Necrosis Factor Inhibitor Use Increases Birthweight in Pregnant Women With Rheumatoid Arthritis Independently of the Soluble Fms‐Like Tyrosine Kinase‐1/Placental Growth Factor Ratio
Background: To study whether the use of TNF (tumor necrosis factor) inhibitors (TNFi) by pregnant women with rheumatoid arthritis affects sFlt‐1 (soluble Fms‐like tyrosine kinase‐1), PlGF (placental growth factor), or their impact on birthweight. Methods and Results: sFlt‐1 and PlGF were measured in all trimesters of pregnancy in the Preconception Counseling in Active Rheumatoid Arthritis study and were compared according to the use of TNFi. The association of sFlt‐1 and PlGF with birthweight in relation to TNFi was determined. The study included 158 women, of whom 52.5% used TNFi during pregnancy. Both sFlt‐1 and PlGF increased during pregnancy, whereas their ratio declined. Taking into consideration the trimester‐related variation in levels of sFlt‐1 and PlGF, after correction for relevant confounders, the sFlt‐1/PlGF ratio was not significantly different between patients who did or did not use TNFi (sFlt‐1/PlGF ratio in the second trimester compared with the first trimester: estimated change 8.17 [95% CI, 2.54–26.29], P =0.79; sFlt‐1/PlGF ratio in the third trimester compared with the first trimester: estimated change 6.25 [95% CI, 1.73–22.50], P =0.25). In women who did not use TNFi, birthweight was significantly lower (3180 versus 3302 g; P =0.03), and sFlt‐1 displayed a negative correlation with birthweight ( r =−0.462, P r =−0.332, P =0.008). In TNFi users, these correlations were absent. Conclusions: TNF inhibitor use increases birthweight in pregnant women with rheumatoid arthritis independently of the sFlt‐1/PlGF ratio. Registration: http://clinicaltrials.gov . Unique identifier: NCT01345071.