Geeta Sharma

This file contain information on the Cell lines and organoids used in this study

This file contains details of the BE sgRNA library

Supplementary Figure 1. Generating base editor-expressing MSI cell lines for screening. Supplementary Figure 2. Quality control for base-editor screens in MSI cell lines. Supplementary Figure 3. Discovery and characterization of novel inhibitors of WRN helicase. Supplementary Figure 4. Correlation of WRN inhibitor sensitivity with genetic and molecular markers in MSI models. Supplementary Figure 5. Comparative analysis of DNA damage in MSI and MSS cells treated with WRN inhibitors and genetic inactivation. Supplementary Figure 6: Effects of GSK_WRN4 on MSI and MSS colorectal cancer xenografts.

This table lists the results from Base editing screen

Expression proteomic signature

Photo affinity labelling (PAL)

Table S8 from Synergistic Effects of PARP Inhibition and Cholesterol Biosynthesis Pathway Modulation

Selectivity profile live cells (2D-TPP)

PanPARP matrix (affinity enrichment chemoproteomics)

Detection of 24,25-epoxycholesterol